Publications by Claudio Bruschini

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sCMOS imagers are currently utilized (replacing EMCCD imagers) to increase the acquisition speed in super resolution localization microscopy. Single-photon avalanche diode (SPAD) imagers feature frame rates per bit depth comparable to or higher than sCMOS ...

This paper uses the simplified charge-based EKV MOSFET model for studying the effects of total ionizing dose (TID) on analog parameters and figures-of-merit (FoMs) of 28nm bulk MOSFETs. These effects are demonstrated to be fully captured by the five key pa ...

We present a comprehensive analysis to guide the use of the nonlinear photon response in photon-counting arrays to extend their optical dynamic range far beyond 1/Tdead, where Tdead is the pixel dead time after photon detection, so as to achieve a high dynamic range of >120 dB. This extension depends on the actual recharge (or reset) mode applied to the photon-counting pixels, where each mode features a different photon response and signal-to-noise ratio. While linearizing the photon response, the signal-to

Single-photon avalanche diodes (SPADs) are direct photon-to-digital detectors that enable scalable arrays with Poisson-limited signal-to-noise ratio and picosecond timing resolution. However, SPAD detectors require a guard-ring structure to prevent lateral ...

Fluorescence lifetime imaging microscopy (FLIM) is a powerful imaging technique that enables the visualization of biological samples at the molecular level by measuring the fluorescence decay rate of fluorescent probes. This provides critical information a ...

Fluorescence Lifetime Imaging (FLI) is widely used in biomedical research for its high sensitivity and detailed cellular insights. It is effective for multiplexed studies and provides information about metabolic states, protein interactions, and ligand-target engagements, independent of signal intensity and fluorophore concentration. Traditional FLI techniques are slow and computationally demanding. This study addresses these limitations by implementing a deep learning-based sequence-to-sequence model direc

We present the design and preliminary simulated performance of a highly scalable TOF-PET detector concept. The UTOFPET project aims at the development of a TOF-PET detector module, with beyond-state-of-the-art performance, that is designed to be well suited for various applications, from brain-dedicated to total-body PET. The UTOFPET detector is based on a continuous scintillator crystal read out by 256 SiPMs, arranged in a 16 × 16 matrix whose outputs are processed by a stack of local processing and data a

We present a novel quantum imaging modality based on photon correlation measurement with a single photon avalanche diode (SPAD) array in a confocal setup. This enables unprecedented simplicity in realization of photon correlation measurements, demonstrated via measuring of second and third order photon correlations of quantum light sources, and the implementation of a quantum based super-resolution technique.

We present recent developments in quantum ghost imaging (QGI) that advance the technique. Previously, QGI was principally a demonstration of an imaging technique that utilized entangled photons. We expand on the method to perform bioimaging of undisturbed plant samples. Under the imaging conditions, plants experience less light than they would under starlight, leaving the plant unaware of the imaging. We will describe the technical considerations for implementing high-quality QGI using SPAD array detectors

This paper presents the first experimental investigation and physical discussion of the cryogenic behavior of a commercial 28 nm bulk CMOS technology. Here we extract the fundamental physical parameters of this technology at 300,77 and 4.2 K based on DC me ...

We describe the performance of a new wide area time-gated single-photon avalanche diode (SPAD) array for phasor-FLIM, exploring the e!ect of gate length, gate number and signal intensity on the measured lifetime accuracy and precision. We conclude that the detector functions essentially as an ideal shot noise limited sensor and is capable of video rate FLIM measurement. The phasor approach used in this work appears ideally suited to handle the large amount of data generated by this type of very large sensor

Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily ...

Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a rela ...

Major advances in silicon pixel detectors, with outstanding timing performance, have recently attracted significant attention in the community. In this work we present and discuss the use of state-of-the-art Geiger-mode APDs, also known as single-photon av ...

The paper presents a camera comprising 512 x 128 pixels capable of single-photon detection and gating with a maximum frame rate of 156 kfps. The photon capture is performed through a gated single-photon avalanche diode that generates a digital pulse upon p ...

Digital SiPMs in the recent past have emerged as a viable low cost alternative to PMTs providing higher granularity and MRI compatibility. The rich dataset generated by digital SiPM sensors have posed a challenge, especially at the system level when a mult ...

Developing large arrays of single-photon avalanche diodes (SPADs) with on-chip time-correlated single-photon counting (TCSPC) capabilities continues to be a difficult task due to stringent silicon real estate constraints, high data rates and system complex ...

We realized subsurface fluorescence LiDAR with a large format single-photon avalanche diode array capable of localizing and quantifying concentration of fluorescent molecules in heavily scattering media, such as tissue, with submillimeter depth accuracy. ( ...

Scintillators play a key role in the detection chain of several applications which rely on the use of ionizing radiation, and it is often mandatory to extract and detect the generated scintillation light as efficiently as possible. Typical inorganic scinti ...

CMOS Single-Photon Avalanche Diodes (SPADs) have broken into the mainstream by enabling the adoption of imaging, timing, and security technologies in a variety of applications within the consumer, medical and industrial domains. The continued scaling of te ...

Claudio Bruschini

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SPAD imagers for super resolution localization microscopy enable analysis of fast fluorophore blinking

Total Ionizing Dose Effects on Analog Performance of 28 nm Bulk MOSFETs

High-dynamic-range imaging with photon-counting arrays (Conference Presentation)

Optical-stack optimization for improved SPAD photon detection efficiency

Light- field tomographic fluorescence lifetime imaging microscopy

FPGA implementation of sequence-to-sequence encoder-decoder deep learning model for real-time fluorescence parameter estimation through SwissSPAD2 camera

UTOFPET: a highly scalable TOF-PET detector concept

Quantum imaging with SPAD arrays

Moving quantum ghost imaging from demonstration to application

Cryogenic Characterization of 28 nm Bulk CMOS Technology for Quantum Computing

Wide-Field Time-Gated SPAD Imager for Phasor-Based FLIM Applications

Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera

Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation

Sub-10 ps Minimum Ionizing Particle Detection With Geiger-Mode APDs

Photon-Counting Arrays for Time-Resolved Imaging

Sensor Network Architecture for a Fully Digital and Scalable SPAD based PET System

Fluorescence lifetime imaging with a single-photon SPAD array using long overlapping gates: an experimental and theoretical study

Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR

Light Extraction Enhancement Techniques for Inorganic Scintillators

Engineering Breakdown Probability Profile for PDP and DCR Optimization in a SPAD Fabricated in a Standard 55nm BCD Process