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Philippe Renaud

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Related publications (301)

Microfluidic sensor and method for obtaining such a sensor

Philippe Renaud, Marc Lany, Thomas Michael Braschler, David Vincent Bonzon, Georges Muller, Luc Gaëtan Aeberli, Jonas Choppe, Niklas Van Neyghem

The invention describes a method for producing hybrid microelectronic/microfluidic sensors at industrial scale. The method is characterized in that it comprises the following steps for obtaining said microfluidic channel: a) a first lamination step of a dr ...

2018

Ultrathin Alumina Membranes as Scaffold for Epithelial Cell Culture from the Intestine of Rainbow Trout

Philippe Renaud, Songmei Wu, Kristin Schirmer, Carolin Drieschner

Permeable membranes are indispensable for in vitro epithelial barrier models. However, currently available polymer-based membranes are low in porosity and relatively thick, resulting in a limited permeability and unrealistic culture conditions. In this stu ...

Amer Chemical Soc2017

Passive flow control valve for protein delivery

Philippe Renaud, Harald Van Lintel

Passive ow control valves are usually intended to deliver or drain a uid at a constant rate independently of pressure variations. Micro uidic devices made of a stack of two plates are considered here: the rst plate comprises a exible silicon membrane havin ...

2017

Single cell isolation process with laser induced forward transfer

Philippe Renaud, Yu Deng, Ying Chen

Background A viable single cell is crucial for studies of single cell biology. In this paper, laser-induced forward transfer (LIFT) was used to isolate individual cell with a closed chamber designed to avoid contamination and maintain humidity. Hela cells ...

Biomed Central Ltd2017

Dielectrophoresis as a single cell characterization method for bacteria

Philippe Renaud, Thomas Michael Braschler, John McKinney, Neeraj Dhar, Ana Valero

Real-time, quantitative characterization of cells at single-cell resolution, particularly while maintain- ing their intrinsic properties and without affecting cellular processes, is of primary importance in modern biological assays. Dielectrophoresis is a ...

Iop Publishing Ltd2017

Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment

Philippe Renaud

Lab-on-a-chip systems are increasingly used as tools for cultures and investigation of cardiac cells. In this article, we present how the geometry of microsystems and microenvironmental conditions (static and perfusion) influence the proliferation, morphol ...

Sage Publications Inc2017

Microfluidic system for monitoring of cardiac (H9C2) cell proliferation

Philippe Renaud

The paper presents the application of electrical impedance spectroscopy (EIS) analysis for investigation of cardiac cell (H9C2 – rat cardiomyoblast) proliferation after verapamil hydrochloride exposure. For this purpose, two different PDMS/glass microsyste ...

2017

In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system

Philippe Renaud, Arnaud Bertsch, Philippe Colin, Bernard Schneider, Guillaume Cédric Yves Petitpierre, Aurélien Thomas

Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temporal resolution. Here we show a functional in v ...

Nature Publishing Group2017

Multimaterial Nanoporous Membranes Shaped through High Aspect-Ratio Sacrificial Silicon Nanostructures

Philippe Renaud, Arnaud Bertsch, Stefano Silvio Giovanni Varricchio, Niccolo Piacentini

We present an innovative fabrication method for solid-state nanoporous membranes based on the casting of sacrificial silicon nanostructures. The process allows the individual definition of geometry and placement of each nanopore through e-beam lithography ...

Amer Chemical Soc2017

A reproducible method for μm precision alignment of PDMS microchannels with on-chip electrodes using a mask aligner

Philippe Renaud, Jonathan Bastien Cottet

This paper describes a reproducible method for μm precision alignment of polydimethylsiloxane (PDMS) microchannels with coplanar electrodes using a conventional mask aligner for lab-on-a-chip applications. It is based on the use of a silicon mold in combin ...

American Institute of Physics2017

Shapeable scaffold material and uses thereof

Philippe Renaud, Thomas Michael Braschler, Giorgio Pietramaggiori, Amélie Barbara Hildegarde Béduer

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

2017

Device for high- throughput sample slicing and characterization

Philippe Renaud, Robert Meissner

The invention relates to devices and systems for use in the slicing, separation and possible disposal of slices of a sample, such as a bodily tissue sample. The invention relates to a multi-blade chopper and a guide track comprising knobs along its surface ...

2017

Endoluminal nerve modulation device and methods for using thereof

Philippe Renaud, Guillaume Cédric Yves Petitpierre

The invention provides for a device (100) for use in electrical nerve modulation in a subject, characterized in that it comprises a rotational and linear actuator (110); a tubular element (101) having a proximal end connected to the actuator (110) and a di ...

2017

Devices, systems and methods for dispensing and analysing particles

Philippe Renaud, Yann Barrandon, David Vincent Bonzon, Jean-Baptiste Bureau, Steve Béguin

The present invention relates to a pipette tip comprising a thin holed membrane at its distal end, which is designed to be adapted with a system comprising at least an impedance analyser and a fluidic actuator to perform the dispensing and analysis of part ...

2016

Observation device with optical compensation

Philippe Renaud, Yann Barrandon, David Vincent Bonzon, David Forchelet, Steve Béguin

The invention concerns an observation device such as cell culture wells comprising an optical element such as a lens or a filter, or even combinations thereof, for compensating an optical effect induced on a sample contained in the observation device and i ...

2016

Ophthalmic contact lens with a compressible affinity matrix

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutral ...

2016

Droplet extraction module for the analysis of segmented flow generated by a neural probe

Philippe Renaud, Arnaud Bertsch, Guillaume Cédric Yves Petitpierre, Colin Darbellay

We recently developed a neural probe allowing to capture at high temporal resolution nano-volume droplets of interstitial fluid from the brain organized in a segmented flow. In order to enable the analysis of these small volume and low concentration drople ...

2016

Biomimetic surface patterning for long-term transmembrane access

Philippe Renaud, Jules John Vandersarl

Here we present a planar patch clamp chip based on biomimetic cell membrane fusion. This architecture uses nanometer length-scale surface patterning to replicate the structure and function of membrane proteins, creating a gigaohm seal between the cell and ...

Nature Research2016

Sensing Tip with Electrical Impedance Sensor

Philippe Renaud, Yann Barrandon, David Vincent Bonzon

The invention relates to a sensing tip (8) comprising a conventional tip (1), such as a pipette tip, which is essentially made of a cavity which communicates with the external environment through an aperture (3) located at the tip distal end; the sensing t ...

2016

Design And Fabrication Of A Well-set, Cost-effective Device For Mechanical And Biochemical Stimulation In Cardiac Tissue Engineering Applications

Philippe Renaud, Niccolo Piacentini, Fatemeh Navaee

2016

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