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Horst Vogel

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Related publications (116)

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Henning Paul-Julius Stahlberg, Horst Vogel, Ghérici Hassaïne

The mouse serotonin 5-HT3A receptor is a homo-pentameric ligand-gated ion channel (pLGIC) mediating fast excitatory neurotransmission in the central nervous system. The molecular mechanism of ion permeation of 5-HT3A receptors triggered by the neurotransmi ...

Pergamon-Elsevier Science Ltd2017

A Gating Mechanism of the Serotonin 5-HT3 Receptor

Horst Vogel, Shuguang Yuan

Our recently solved high-resolution structure of the serotonin 5-HT3 receptor (5-HT3R) delivered the first detailed structural insights for a mammalian pentameric ligand-gated ion channel. Based on this structure, we here performed a total of 2.8-μs all-at ...

Cell Press2016

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Luigino Grasso, Ghérici Hassaïne

The function of membrane proteins is best understood if their structure in the lipid membrane is known. Here, we determined the structure of the mouse serotonin 5-HT3 receptor inserted in lipid bilayers to a resolution of 12 Å without stabilizing antibodie ...

Elsevier2016

PyMOL and Inkscape Bridge the Data and the Data Visualization

Horst Vogel, Shuguang Yuan

Structural biology has come a long way, from being a niche interest of specialists to where we are today, with over 127,500 biomolecular structures available in the Protein Data Bank (PDB) as of the writing of this letter. The two main factors that have be ...

Elsevier2016

Signal transmission by ligand-gated ion channels

Horst Vogel

Oxford Univ Press2016

Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

Horst Vogel, Shuguang Yuan

G-protein-coupled receptors (GPCRs) are involved in a wide range of physiological processes, and they have attracted considerable attention as important targets for developing new medicines. A central and largely unresolved question in drug discovery, whic ...

Wiley-Blackwell2016

The Molecular Mechanism of P2Y 1 Receptor Activation

Horst Vogel, Shuguang Yuan

Human purinergic Gprotein-coupled receptor P2Y(1) (P2Y(1)R) is activated by adenosine 5'-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Crystal structures of P2Y(1)R revealed that one ligand ( ...

Wiley-Blackwell2016

Use of fourier transform infrared spectroscopy analysis of extracellular vesicles isolated from body fluids for diagnosing, prognosing and monitoring pathophysiological states and method therfor

Horst Vogel, Luigino Grasso, Romain Wyss

The method analyzes biological fluids collected from patients, and uses attenuated total reflecting (ATR) sensors and spectral analysis by Fourier transform infrared spectroscopy (FTIR) to form a spectral fingerprint of extracellular vesicles (EVs) isolate ...

2016

Observation of the rare B-s(0)->mu(+)mu(-) decay from the combined analysis of CMS and LHCb data

Horst Vogel, Christoph Frei, Peter Clarke, Jean Wicht, Alessandro Mapelli, Aurelio Bay, Minh Tâm Tran, Andrea Rizzi, Marc-Olivier Bettler, Cédric Potterat, Matthias Finger, Tatsuya Nakada, Guido Haefeli, Niko Neufeld, Olivier Schneider, Pierre Jaton, Hans Dijkstra, Julien Rouvinet, Charles Dietz, João Miguel das Neves Duarte, Frédéric Guillaume Dupertuis, Frédéric Teubert, Gerhard Raven, Quentin Python, Bastien Luca Muster, Joo Yeon Kim, Alexis Kalogeropoulos, Chitsanu Khurewathanakul, Frédéric Blanc, Matthew Needham, Lesya Shchutska, Liang Sun, Alexandre Aubin, Yixing Chen, Tian Cheng, Ioannis Papadopoulos, Wei Sun, Barinjaka Rakotomiaramanana, Xiaoxue Han, Qian Wang, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Single-Molecule Imaging Deciphers the Relation between Mobility and Signaling of a Prototypical G Protein-Coupled Receptor in Living Cells

Horst Vogel, Joachim Piguet, Luc Veya

Lateral diffusion enables efficient interactions between membrane proteins leading to signal transmission across the plasma membrane. An open question is how the spatio-temporal distribution of cell surface receptors influences the transmembrane signaling ...

American Society for Biochemistry and Molecular Biology2015

The Mechanism of Ligand-Induced Activation or Inhibition of - and -Opioid Receptors

Horst Vogel, Shuguang Yuan

G-protein-coupled receptors (GPCRs) are important targets for treating severe diseases. However why certain molecules act as activators whereas others, with similar structures, block GPCR activation, is poorly understood since the same molecule can activat ...

Wiley-Blackwell2015

W246(6.48) Opens a Gate for a Continuous Intrinsic Water Pathway during Activation of the Adenosine A(2A) Receptor

Horst Vogel, Shuguang Yuan, Zhenquan Hu

The question how G-protein-coupled receptors transduce an extracellular signal by a sequence of transmembrane conformational transitions into an intracellular response remains to be solved at molecular detail. Herein, we use molecular dynamics simulations ...

Wiley-VCH Verlag GmbH2015

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Horst Vogel, Michel Prudent, Niels Erik Lion, Luigino Grasso, Romain Wyss, Davide Demurtas, Ashwin Thampi, Lorenz Weidenauer

We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...

Springer Heidelberg2015

Microfluidic Single-Cell Analysis with Affinity Beads

Rudolf Hovius, Horst Vogel, Loïc Arvind Roger Arm, Michael Werner

A micrometer-sized affinity bead (red) is (i) taken up into a cell by phagocytosis, (ii) photochemically released from phagosomes, (iii) optically trapped by the cell, and (iv) isolated by cell lysis for subsequent analysis of captured intracellular analyt ...

2015

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Vogel, Horst Pick, Olivia Baud, Luc Veya, Shuguang Yuan

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

X-ray structure of the mouse serotonin 5-HT3 receptor

Rudolf Hovius, Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Luigino Grasso, Romain Wyss, Menno Berend Tol, Ghérici Hassaïne

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly un ...

Nature Publishing Group2014

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

Horst Vogel, Luigino Grasso, Romain Wyss, Davide Demurtas, Camille Wolf, Hans Wolfgang Grosse

Cells secrete extracellular vesicles (EVs) into their microenvironment that act as mediators of intercellulard communication under physiological conditions and in this context also actively participate in spreading various diseases. Large efforts are curre ...

Amer Chemical Soc2014

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Horst Vogel, Shuguang Yuan

Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, ...

Nature Publishing Group2014

Large scale expression and purification of the mouse 5-HT3 receptor (vol 1828, pg 2544, 2013)

Horst Vogel, Cédric Deluz, Menno Berend Tol, Ghérici Hassaïne

Elsevier Science Bv2014

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking

Horst Vogel, Romain Wyss, Romano Tobias Wyss

Amer Soc Cell Biology2014

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The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilitie ...

Nature Publishing Group2015