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Dominique Pioletti

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Related publications (190)

Isolation and in vitro chondrogenic potential of human fetal spine cells

Dominique Pioletti, Sandra Jaccoud, Aurélie Quintin, Corinne Scaletta, Lee Ann Laurent-Applegate

Cell therapy for nucleus pulposus regeneration is an attractive treatment for early disc degeneration as shown by studies using autologous nucleus pulposus cells or stem cells. Another potential source of cells is fetal cells. We investigated the feasibili ...

2009

Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can ...

2009

Dynamical biomechanical model of the shoulder: null space based optimization of the overactuated system

Dominique Pioletti, Denis Gillet, Philippe Müllhaupt, Alexandre Terrier, Yvan Michellod, Martin Aeberhard

A new dynamical model of the shoulder has been developed. It consists of eleven muscles. The glenohumeral joint, modeled as a spherical joint, allows three rotations and blocks the translations. Muscle wrapping around a spherical humeral head is calculated ...

2009

Cellular gradient polymer composites

Dominique Pioletti, Pierre-Etienne Bourban, Vincent Stadelmann, Manuel Bühler

The invention relates to a foamed polymer composite product incorporating several fillers and/or fibres and several pores characterized by the fact that it shows two distinct gradients, namely a filler and/or fibre density gradient and a pore density gradi ...

2008

Orthopedic implant used as drug delivery system: clinical situation and state of the research

Dominique Pioletti, Vincent Stadelmann

A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondl ...

2008

Fluid flow in peri-implanthealing soft tissue

Dominique Pioletti, Alexandre Terrier, Miguel Gortchacow

Gordon and Breach Pub2008

Wound healing gene-family expression differences between fetal and foreskin cells used for bioengineered skin substitutes

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta, Lee Ann Laurent-Applegate

For tissue engineering, several cell types and tissues have been proposed as starting material. Allogenic skin products available for therapeutic usage are mostly developed with cell culture and with foreskin tissue of young individuals. Fetal skin cells o ...

2008

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Lee Ann Laurent-Applegate, Claire Diane Delabarde

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

Human muscular fetal cells: a potential cell source for muscular therapies

Dominique Pioletti, Nathalie Hirt-Burri, Corinne Scaletta

Myoblast transfer therapy has been extensively studied for a wide range of clinical applications, such as tissue engineering for muscular loss, cardiac surgery or Duchenne Muscular Dystrophy treatment. However, this approach has been hindered by numerous l ...

2008

Evaluation of knee instability related to tibial tray posterior slope

Dominique Pioletti, Alexandre Terrier, Pierre-François Leyvraz

Gordon and Breach Pub.2008

A composite biofoam, from research to in vivo validation

Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Biomechanical evaluation of intra-articular and extra-articular procedures in anterior cruciate ligament reconstruction: A finite element analysis

Dominique Pioletti, Perrine Saunier

Background. Intra-articular techniques (single and double bundles) are the most widely used procedures for the anterior cruciate lig- ament reconstruction. Lemaire introduced in 1967 the extra-articular techniques, and combined intra-articular and extra-ar ...

2007

Polylactic acid-phosphate glass composite foams as scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban

Phosphate glass (PG) of the composition 0.46(CaO)-0.04(Na(2)O)- 0.5(P(2)O(5)) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous c ...

2007

Consistency of fetal cell banks for research and clinical use

Dominique Pioletti, Aurélie Quintin, Corinne Scaletta, Lee Ann Laurent-Applegate

Current restrictions for human cell-based therapies have been related to technological limitations with regards to cellular proliferation capacity and maintenance of differentiated phenotype for primary human cell culture. In our experience, we have seen t ...

2007

Repair of critical size defects in the rat cranium using ceramic-reinforced PLA scaffolds obtained by supercritical gas foaming

Dominique Pioletti, Pierre-Etienne Bourban, Lee Ann Laurent-Applegate

Bioresorbable scaffolds made Of poly(L-lactic acid) (PLA) obtained by supercritical gas foaming were recently described as suitable for tissue engineering, portraying biocompatibility with primary osteoblasts in vitro and interesting mechanical properties ...

2007

Polylactic Acid–Phosphate Glass Composite Foams as Scaffolds for Bone Tissue Engineering

Dominique Pioletti, Pierre-Etienne Bourban

Phosphate glass (PG) of the composition 0.46(CaO)–0.04(Na2O)–0.5(P2O5) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous composit ...

2006

Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats

Bastian Peter, Dominique Pioletti, Randoald Müller

Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate ...

2006

Total joint replacement and aseptic loosening

Dominique Pioletti

2006

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