Publication

Using drug delivery systems to enhance joint replacement

Dominique Pioletti
2008
Book Chapters

Abstract

Why do we need to improve the outcome of orthopedic implants? What is the clinical situation for orthopedic implant used as drug delivery system? Is the research for orthopedic drug delivery system advanced enough to translate it to clinical applications? Will drug delivery systems be the future for orthopaedic implants? References

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Dominique Pioletti
2008
Book Chapters

Abstract

Official source

Related concepts (14)

Implant (medicine)

An implant is a medical device manufactured to replace a missing biological structure, support a damaged biological structure, or enhance an existing biological structure. For example, an implant may be a rod, used to strengthen weak bones. Medical implants are human-made devices, in contrast to a transplant, which is a transplanted biomedical tissue. The surface of implants that contact the body might be made of a biomedical material such as titanium, silicone, or apatite depending on what is the most functional.

Drug delivery

Drug delivery refers to approaches, formulations, manufacturing techniques, storage systems, and technologies involved in transporting a pharmaceutical compound to its target site to achieve a desired therapeutic effect. Principles related to drug preparation, route of administration, site-specific targeting, metabolism, and toxicity are used to optimize efficacy and safety, and to improve patient convenience and compliance. Drug delivery is aimed at altering a drug's pharmacokinetics and specificity by formulating it with different excipients, drug carriers, and medical devices.

Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought.

Related publications (5)

Using drug delivery systems to enhance joint replacement

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