Publication

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Publications associées (18)

Impact of substrate clogging on vertical connectivity

Giovanni De Cesare, Romain Maxime Dubuis, Robin Schroff

Connectivity between the hyporheic zone and the flow is essential for the development of benthos and the reproductive success of spawning fish. The infiltration of fine sediment leads to clogging of the riverbed, reducing porosity and vertical water exchan ...

2023

Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds

Paul Joseph Dyson, Sarah Alexandra Pais Pereira

A novel automated method based on sequential injection analysis (SIA), a non-segmented flow injection technique, was developed to evaluate glutathione S-transferase P1-1 (GST P1-1) activity in the presence of organometallic complexes with putative anticanc ...

TAYLOR & FRANCIS LTD2022

UAV in the advent of the twenties: Where we stand and what is next

Jan Skaloud, Davide Antonio Cucci

The use of Unmanned Aerial Vehicles (UAVs) has surged in the last two decades, making them popular instruments for a wide range of applications, and leading to a remarkable number of scientific contributions in geoscience, remote sensing and engineering. H ...

2022

Challenges for biophysical modeling of microstructure

Ileana Ozana Jelescu

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020

Synthetic Studies toward Amanita Phalloides Toxins

Philipp Georg Werner Seeberger

Amatoxins are ribosomally synthesized and post-translationally modified bicyclic octapeptides biosynthesized by the deadly basidiomycete fungus Amanita phalloides. Amongst this group, alpha-amanitin is the most widely known toxin and is currently under inv ...

EPFL2020

Energy efficiency as an example of cross-discipline collaboration in chemical engineering

François Maréchal

This paper summarizes the round-table discussion that was held during the European Congress of Chemical Engineering (ECCE) in Nice, France, in October 2015 on this topic. The panellists come from different fields of chemical engineering and have thus broug ...

2017

An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode

Paul Joseph Dyson, Ursula Röthlisberger, Thibaud Edouard Alistair von Erlach, Giulia Palermo, Benjamin Samuel Murray

Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many different intercalator compounds have been studied because of their activity as mutagens or drugs ...

Wiley-VCH Verlag GmbH2016

Opening the lid on piano-stool complexes: An account of ruthenium(II)-arene complexes with medicinal applications

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Interest in the medicinal properties of ruthenium(II)-arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that ...

Elsevier Science Sa2014

DprE1-from the Discovery to the Promising Tuberculosis Drug Target

Joao Pedro De Almeida Neres

Several groups working in the field of the development of new antituberculosis drugs have recently reported active compounds targeting mycobacterial enzyme DprE1. Along with its counterpart, DprE2, it catalyses a unique epimerization reaction resulting in ...

Bentham Science Publ Ltd2014

Scientific diasporas, transnationalism and home-country development: evidence from a study of skilled Moldovans abroad

Gabriela Tejada Guerrero

This paper discusses the Moldovan ‘scientiﬁc diaspora’ made up of students, researchers and those engaged in professional activities abroad, and their propensity to either return or engage in home-country development initiatives. Moldova has suffered a sig ...

Routledge Journals, Taylor & Francis Ltd2013

The alignment between institutions and technology in network industries

Matthias Finger, Nicolas Crettenand

Network industries, such as electricity, railways and air transport, are very complex technical, economic, and political systems in which the alignment between technology and institutions has a significant impact on performance. This alignment has been stu ...

2013

Visualizing Biochemical Activities in Living Cells through Chemistry

Kai Johnsson, Luc Reymond, Matthias Albert Brun, Karolina Bojkowska, Birgit Mollwitz, Grazvydas Lukinavicius, Anastasiya Masharina, Alberto Schena, Keitaro Umezawa, Rudolf Griss

The development of molecular probes to visualize cellular processes is an important challenge in chemical biology. One possibility to create such cellular indicators is based on the selective labeling of proteins with synthetic probes in living cells. Over ...

2011

Direct Alkynylation of Indole and Pyrrole Heterocycles

Julie Charpentier, Jérôme Waser, Jonathan Brand

Easy does it: The unique properties of benziodoxolone alkynyl periodinane 1 and gold catalysts have allowed the development of a high yielding, operationally simple (room temperature, no dry solvents or inert conditions, commercially available catalyst) re ...

Wiley-VCH Verlag GmbH2009

Recent knowledge and innovations related to hexofuranosides: structure, synthesis and applications

Ronan Euzen

Hexofuranosides are widely spread in nature, and notably in numerous pathogenic microorganisms. This particular five-membered ring for hexosides leads to novel biological properties and, as usual in glycochemistry, to completely different reactivity and se ...

2008

Development of organometallic ruthenium(II) anticancer (RAPTA) drugs

Wee Han Ang

A review. The systematic development of the RAPTA family of organometallic ruthenium(II) anticancer drugs contg. a monodentate 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand and a h6-arene ligand is described. ...

2007

Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis

Paul Joseph Dyson, Wee Han Ang

The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is convalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative ...

2007

The 2 * 3 toolbox of organometallic methods for regiochemically exhaustive functionalization

A review. This review describes a concept aimed at rational and maximal structure proliferation. To this end, simple arom. or heterocyclic starting materials, often bulk chems., are converted into all regioisomerically possible polar organometallic interme ...

Wiley-VCH Verlag GmbH2005

Development of organometallic (organo-transition metal) pharmaceuticals

Paul Joseph Dyson, Antoine Dorcier, Claudine Scolaro, Claire Samantha Allardyce

This paper is aimed at introducing the organometallic chemist to the fascinating area of organometallic pharmaceuticals. It commences by identifying the properties of organometallic (transition metal) compounds that lend themselves to medical applications. ...

2005