Transgenic Model Systems Have Revolutionized the Study of Disease

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A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

Type inference in the presence of first-class or "impredicative" second-order polymorphism a la System F has been an active research area for several decades, with original works dating back to the end of the 80s. Yet, until now many basic problems remain ...

During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and ...

The collimation system of the Future Circular Collider, operating with leptons (FCC-ee), must protect not only the experiments against backgrounds, but also the machine itself from beam losses. With a 17.8 MJ stored energy of the electron and positron beam ...

We focus on distinctive data-driven measures of the fate of ongoing epidemics. The relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to th ...

Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

Consider the wave equation with heterogeneous coefficients in the homogenization regime. At large times, the wave interacts in a nontrivial way with the heterogeneities, giving rise to effective dispersive effects. The main achievement of the present wor ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

This article presents a portfolio construction approach that combines the hierarchical clustering of a large asset universe with the stock price momentum. On one hand, investing in high-momentum stocks enhances returns by capturing the momentum premium. On ...

The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

Recently, Pham et al. used an array of model systems to uncover a role for the enzyme methionine adenosyltransferase (MAT) -1A, which is mainly expressed in liver, in both sensing formaldehyde and regulating transcriptional responses that protect against i ...

Background Immersive virtual reality (iVR)-based digital therapeutics are gaining clinical attention in the field of pain management. Based on known analogies between pain and dyspnoea, we investigated the effects of visual respiratory feedback on persiste ...

Historically speaking, the notion of the type was reintroduced to the larger architectural discourse as a direct consequence of the crisis of the Modern. The task of revisiting the forms of the past also dictated the return of architectural methods that ha ...

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia 3 . ...

In the context of SARS-CoV-2 pandemic, mathematical modelling has played a funda-mental role for making forecasts, simulating scenarios and evaluating the impact of pre-ventive political, social and pharmaceutical measures. Optimal control theory represent ...

Native reactive electrophilic species (RES) are long-recognized regulators of pathophysiology; yet, knowledge surrounding how RES regulate context-specific biology remains limited. The latest technological advances in profiling and precision decoding of RE ...

Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...

Type systems usually characterize the shape of values but not their free variables. However, many desirable safety properties could be guaranteed if one knew the free variables captured by values. We describe CC

Revision behavior in adaptive writing support systems is an important and relatively new area of research that can improve the design and effectiveness of these tools, and promote students' self-regulated learning (SRL). Understanding how these tools are u ...

Time has always been a central factor in understanding the challenges of daily mobility. For a long time, and still today, methods of economic evaluation of transport projects have monetized time savings so that they can be included in the cost–benefit ana ...

Transgenic Model Systems Have Revolutionized the Study of Disease

Chattez avec Graph Search

Multimodal transcriptomic atlases of mouse spinal cord injury

When Subtyping Constraints Liberate A Novel Type Inference Approach for First-Class Polymorphism

Challenges of COVID-19 Case Forecasting in the US, 2020-2021

Collimation simulations for the FCC-ee

Epidemicity indices and reproduction numbers from infectious disease data in connected human populations

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

A Spectral Ansatz for The Long-Time Homogenization of The Wave Equation

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Portfolio Construction with Hierarchical Momentum

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Formaldehyde regulates one-carbon metabolism and epigenetics

Virtual reality intervention alleviates dyspnoea in patients recovering from COVID-19 pneumonia

Between the Pattern and the Type: A short parallel story

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: An application to the Italian scenario

Structural Insights into Electrophiles and Electrophilic Metabolites Sensing and Signaling: The Missing Information

Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma

Capturing Types

Understanding Revision Behavior in Adaptive Writing Support Systems for Education

Appropriations and Uses of Travel Time