Non-invasive quantification of brain glycogen absolute concentration

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The oxygen isotope compositions of fossil biocalcites, such as foraminifera, bivalves, brachiopods, and belemnites have allowed for reconstructions of sea surface and deep ocean temperatures throughout the Phanerozoic and constitute the most important reco ...

The two-step electron transfer during bacterial reduction of UVI to UIV is typically accompanied by mass-independent fractionation of the 238U and 235U isotopes, whereby the heavy isotope accumulates in the reduced product. However, the role of the UV inte ...

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

In this report, we demonstrate enlarged grain size (up to-3 lm) in ambient-stable black c-phase CsPbI2Br thin films through the regulated addition of guanidinium iodide (GAI) as an effective volatile additive. Nuclear magnetic resonance (NMR) and X-ray pho ...

To date, the vast majority of studies seeking to link discharge to solute concentrations have been based on representations of fluid age distributions in watersheds that are time-invariant. As increasingly detailed spatial and temporal datasets become avai ...

The paleoseawater temperature record from the oxygen isotope compositions of fossil foraminifera tests may be biased by up to about 1 degrees C due to grain-boundary diffusion alone, according to isotope exchange experiments on foraminifera tests. The oxyg ...

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

Knowledge of oxygen diffusion in garnet is crucial for a correct interpretation of oxygen isotope signatures in natural samples. A series of experiments was undertaken to determine the diffusivity of oxygen in garnet, which remains poorly constrained. The ...

To predict hydrologic responses to inputs and perturbations, it is important to understand how precipitation is stored in catchments, released back to the atmosphere via evapotranspiration (ET), or transported to aquifers and streams. We investigated this ...

Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...

Original data pertaining to the manuscript 'Persistence of the isotopic signature of pentavalent uranium in magnetite' published in Environmental Science and Technology by Zezhen Pan, Yvonne Roebbert, Aaron Beck, Barbora Bartova, Tonya Vitova, Stefan Weyer ...

Uranium isotopic signatures can be harnessed to monitor the reductive remediation of subsurface contamination or to reconstruct paleo-redox environments. However, the mechanistic underpinnings of the isotope fractionation associated with U reduction remain ...

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

The stable isotopes of hydrogen and oxygen in xylem water are often used to investigate tree water sources. But this traditional approach does not acknowledge the contribution of water stored in the phloem to transpiration and how this may affect xylem wat ...

Clinical trials have shown that direct activators of an evolutionary-conserved metabolic sensor, AMP-activated protein kinase (AMPK), are beneficial in preventing/treating a range of metabolic disorders, including type 2 diabetes. These activators, includi ...

Dissolution dynamic nuclear polarization (dDNP) is a powerful technique that enhances the magnetic resonance signal of nuclear spins by several orders of magnitude. DNP relies on the principle of cross-relaxation by electron spins driven out of equilibrium ...

This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field. In the first two chapters, we studied longitudinally t ...

Introduction: Regulation of endogenous glucose production (EGP) is essential for glucose homeostasis. It includes gluconeogenesis (GNG) from non-carbohydrate substrates and hepatic glycogenolysis. Both these pathways are dysregulated in acute stress, but t ...

As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...

O-17 NMR is an invaluable tool to study the structure and dynamics of oxide materials but remains challenging to apply in many systems. Even with isotopic enrichment, studies of samples with low masses and/or concentrations of the active species, such as t ...

Non-invasive quantification of brain glycogen absolute concentration

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Diagenetic isotope exchange in biocalcites for paleoclimate reconstruction

The isotopic signature of U(V) during bacterial reduction

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Controlled crystallization and surface engineering of mixed-halide y-CsPbI2Br inorganic perovskites via guanidinium iodide additive in air-processed perovskite solar cells

Isotope Ratio - Discharge Relationships of Solutes Derived From Weathering Reactions

Rapid grain boundary diffusion in foraminifera tests biases paleotemperature records

Lactate supply overtakes glucose when neural computational and cognitive loads scale up

Oxygen diffusion in garnet: Experimental calibration and implications for timescales of metamorphic processes and retention of primary O isotopic signatures

Precipitation fate and transport in a Mediterranean catchment through models calibrated on plant and stream water isotope data

The role of nicotinamide riboside metabolism in pancreatic beta cells

Persistence of the isotopic signature of pentavalent uranium in magnetite

Persistence of the isotopic signature of pentavalent uranium in magnetite

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

Phloem water isotopically different to xylem water: Potential causes and implications for ecohydrological tracing

Investigation of physiological roles of AMPK-activated protein kinase y3

Mechanistic studies of DNP and applications of hyperpolarized probes to study renal physiology and metabolism

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

Magnitude of gluconeogenesis and endogenous glucose production: are they predictable in clinical settings?

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Endogenous O-17 Dynamic Nuclear Polarization of Gd-Doped CeO2 from 100 to 370 K