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Non-invasive quantification of brain glycogen absolute concentration

Publications associées (29)

Advanced characterization of regioselectively substituted methylcellulose model compounds by DNP enhanced solid-state NMR spectroscopy

David Lyndon Emsley, Michel Bardet, Pierrick Berruyer, Pinelopi Moutzouri

Dynamic Nuclear Polarization MAS NMR is introduced to characterize model methylcellulose ether compounds at natural isotopic abundance. In particular an approach is provided to determine the position of the methyl ether group within the repeating unit. Spe ...

2021

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Rolf Gruetter, Hongxia Lei

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Wiley-Blackwell2020

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Bernard Lanz, Graham Knott, Rolf Gruetter, Nadine Fournier, Caroline Anne-Lyse Contat, Mario Gaetano Lepore, Etienne Meylan, Anders Meibom, Stéphane Laurent Escrig, Justine Pascual, Louise Helene Soegaard Jensen, Anouk Rossier, Pierre-Benoit Bernard Ancey, Silvia Sabatino, Inti Zlobec

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

2020

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport

The small molecule kinase inhibitor SBI-0206965 was originally described as a specific inhibitor of ULK1/2. More recently, it was reported to effectively inhibit AMPK and several studies now report its use as an AMPK inhibitor. Currently, we investigated t ...

2020

Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

Kristina Schoonjans, Adriano Maida

The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and patho ...

2020

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Kristina Schoonjans

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

Nature Research2020

Tree water deficit and dynamic source water partitioning

Andrea Rinaldo, Paolo Benettin, Mitra Asadollahi

The stable isotopes of hydrogen and oxygen (delta H-2 and delta O-18, respectively) have been widely used to investigate tree water source partitioning. These tracers have shed new light on patterns of tree water use in time and space. However, there are s ...

WILEY2020

Plant and root‐zone water isotopes are difficult to measure, explain, and predict: some practical recommendations for determining plant water sources

Charlotte Grossiord, Jana Freiin von Freyberg

Stable isotope ratios of water (𝛿 18O,𝛿 2H) have long been used to study a core question in plant ecology and ecohydrology: “From where do plants take up water?” Indeed, decades of research has involved sampling potential plant water sources in the subsurf ...

2020

Cellulose phosphorylation comparison and analysis of phosphorate position on cellulose fibers

David Lyndon Emsley, Jayasubba Reddy Yarava, Michel Bardet, Julien Bras

Chemical modifications of cellulose fibers as pretreatment for cellulose nanofibrils (CNF) production have been investigated to improve the production process and the quality of obtained cellulosic nanomaterial. In this study, phosphorylation of cellulose ...

ELSEVIER SCI LTD2020