Publications associées à Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

Publications associées (13)

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

BMC2025

Spotlight on Cytochrome B561 and Domon Domain Proteins

Luciano Andres Abriata

Biotic and abiotic stresses constrain plant growth worldwide. Therefore, under-standing the molecular mechanisms contributing to plant resilience is key to achieving food security. In recent years, proteins containing dopamine beta-monooxygenase N-terminal ...

CELL PRESS2025

A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

Jinyun Wu, Ralf Schneggenburger, Olexiy Kochubey, Denys Osypenko, Shriya Palchaudhuri, Bei-Xuan Lin

During fear learning, associations between a sensory cue (conditioned stimulus, CS) and an aversive stimulus (unconditioned stimulus, US) are formed in specific brain circuits. The lateral amygdala (LA) is involved in CS-US integration; however, US pathway ...

2025

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Yesica Gloria

Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stage ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

The Emerging Role of Brain Mitochondria in Fear and Anxiety

Maria del Carmen Sandi Perez, Alessandro Chioino

The functional complexity of brain circuits underlies the broad spectrum of behaviors, cognitive functions, and their associated disorders. Mitochondria, traditionally known for their role in cellular energy metabolism, are increasingly recognized as centr ...

Springer Nature2024

Targeting Cellular Senescence and NAD+ Metabolism Disruption in Early-Stage Chronic Kidney Disease

Lucie Camille Chanvillard

Chronic kidney disease (CKD) is a global public health issue, affecting over 800 million people and ranking as the 9th leading cause of death worldwide, with complications such as cardiovascular disease and muscle wasting contributing to its high mortality ...

EPFL2024

Commentary: Alpha(1)-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

Anna Lasne, Merkourios Simos, Maria del Carmen Sandi Perez

FRONTIERS MEDIA SA2023

Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Rajasekhar Kolla, Deepthy Kavungal, Pedro José Santana Ribeiro Magalhães, Senthil Kumar Thangaraj

Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and fibrillar aggregates plays an i ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Carlos Canto Alvarez, Jérome Feige

Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD(+), but little is known about their contribution to endogenous NAD(+) turnover and muscle plasticity during skeletal muscle growth and remodeling. Usin ...

FRONTIERS MEDIA SA2022

Actigraphy enables home screening of REM behavior disorder in Parkinson's disease: Preliminary data

Eduardo Martin Moraud, Stefano Scafa

WILEY2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

Philipp Bucher, Giovanna Ambrosini

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of alpha-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants link ...

Springer Nature2019

Hyperpolarized acetate as a metabolic tracer for skeletal and cardiac muscle energetics

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Tian Cheng, Mor-Miri Mishkovsky

2011