A Compact Probe for Beta+Emitting Radiotracer Detection in Suregery, Biopsy, and Medical Diagnostics based on Silicon Photomultipliers

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Publications associées (32)

Progress in single-photon avalanche diode image sensors in standard CMOS: From two-dimensional monolithic to three-dimensional-stacked technology

Edoardo Charbon, Myung Jae Lee

Single-photon detection and photon counting are useful tools in many fields, from light detection and ranging (LiDAR) to biomedical imaging and from time-resolved Raman spectroscopy to quantum applications. In this context, recently, single-photon avalanch ...

IOP PUBLISHING LTD2018

The new versatile general purpose surface-muon instrument (GPS) based on silicon photomultipliers for μSR measurements on a continuous-wave beam

Kamil Sedlák

We report on the design and commissioning of a new spectrometer for muon-spin relaxation/rotation studies installed at the Swiss Muon Source (SμS) of the Paul Scherrer Institute (PSI, Switzerland). This new instrument is essentially a new design and replac ...

2017

Inexpensive 1024-Channel 3D Telesonography System on FPGA

Jean-Philippe Thiran, Giovanni De Micheli, Federico Angiolini, Damien Doy, Aya Mohamed Naguib Ahmed Ibrahim, Marcel Arditi

Volumetric ultrasound (US) is a very promising development of medical US imaging. An under-exploited advantage of volumetric US is the mitigation of the strict probe positioning constrains necessary to acquire 2D scans, potentially allowing the decoupling ...

IEEE2017

Single Photon Counting UV Solar-Blind Detectors Using Silicon and III-Nitride Materials

Edoardo Charbon, Preethi Padmanabhan

Ultraviolet (UV) studies in astronomy, cosmology, planetary studies, biological and medical applications often require precision detection of faint objects and in many cases require photon-counting detection. We present an overview of two approaches for ac ...

2016

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

Riccardo Sinisi

Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine dyes possess strong necrosis avid properties in vitro as well as in different mouse models of spontaneous and therapy-induced tumor necrosis, indicating their potenti ...

Springer2016

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

Riccardo Sinisi

Purpose: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocom ...

Frontiers Media Sa2016

Advances in digital SiPMs and their application in biomedical imaging

Edoardo Charbon

Similar to analog silicon photomultipliers (SiPMs), digital SiPMs (dSiPMs) essentially consist of an array of single-photon avalanche photodiodes (SPADs). Instead of a passive quench resistor, however, an active quenching circuit is locally integrated with ...

2015

Structural and Functional Imaging of Pancreatic Islets using Optical Coherence Microscopy

Corinne Berclaz

In diabetes, pancreatic beta-cells play a key role. These cells are organized within structures called islets of Langerhans inside the pancreas and produce insulin. Insulin is one of the main hormones contributing to glucose homeostasis, which is the hallm ...

EPFL2015

Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers

Theo Lasser, Antonio Lopez, Anne Grapin-Botton, Corinne Berclaz, Christophe Pache, Arno Pino Bouwens, Daniel Pawel Szlag

The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are required to assess the specificity of these tracers. We propose to combine Optical Co ...

Nature Publishing Group2015

Near-Infrared Optical Tomography with Single-Photon Avalanche Diode Image Sensors

Juan Mata Pavia

In the past decades different methods based on magnetic resonance imaging (MRI) and positron emission tomography (PET) have been developed to image a variety of hemodynamic parameters in tissue. However, simultaneous high resolution imaging of oxy- and deo ...

EPFL2015

Quenching the scintillation in CF4 Cherenkov gas radiator

Christoph Frei

CF4 is used as a Cherenkov gas radiator in one of the Ring Imaging Cherenkov detectors at the LHCb experiment at the CERN Large Hadron Collider. CF4 is well known to have a high scintillation photon yield in the near and far VUV, UV and in the visible wave ...

Elsevier Science Bv2015

A comparative experimental investigation on responsivity and response speed of photo-diode and photo-BJT structures integrated in a low-cost standard CMOS process

Alexandre Schmid, Yusuf Leblebici, Nikola Katic

A variety of smart imaging and neuromorphic applications perform time-domain image acquisition in order to imitate biological systems and reduce the growing transmission bandwidth of the modern imaging devices. Because they operate in time-domain, they req ...

Elsevier2015

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