To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

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Publications associées (31)

Stereoselective synthesis of alkenes via base-metal-catalyzed addition reactions to alkynes and activation of hydrogen peroxide and carbon dioxide by iron complexes

Fedor Zhurkin

Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...

EPFL2017

One-Pot Three-Component Synthesis of Vicinal Diamines via In Situ Aminal Formation and Carboamination

Jérôme Waser, Ugo Jonathan Orcel

A synthesis of vicinal diamines via in situ aminal formation and carboamination of allyl amines is reported. Employing highly electron-poor trifluoromethyl aldimines in their stable hemiaminal form was key to enable both a fast and complete aminal formatio ...

Wiley-VCH Verlag GmbH2016

Lewis acid Catalyzed Annulations of Donor-Acceptor Aminocyclopropanes and Aminocyclobutanes

Sophie Lucie Racine

Organic molecules are indispensable have greatly contributed to the confort of our modern life. Nevertheless, humanity is facing now new challenges such as environmental issues and emerging drug resistances. In order to solve these major concerns, chemists ...

EPFL2016

Recent developments of iron pincer complexes for catalytic applications

Xile Hu, Gerald Bauer

Iron catalysis is attractive for organic synthesis because iron is inexpensive, abundant, and non-toxic. To control the activity and stability of an iron center, a large number of iron pincer complexes have been synthesized. Many such complexes exhibit exc ...

Chinese Chemical Soc2016

Cyclic Hypervalent Iodine Reagents for Atom-Transfer Reactions: Beyond Trifluoromethylation

Jérôme Waser, Maria Victoria Vita, Yifan Li, Durga Prasada Rao Hari

Hypervalent iodine compounds are privileged reagents in organic synthesis because of their exceptional reactivity. Among these compounds, cyclic derivatives stand apart because of their enhanced stability. They have been widely used as oxidants, but their ...

Wiley-Blackwell2016

Cyclic Hypervalent Iodine Reagents and Pd-Catalysis : Asymmetric Synthesis of α-Alkynyl and α-Azido Carbonyl Compounds

Maria Victoria Vita

Developing new strategies and methods to explore new dimensions of the chemical space represents an important goal for organic chemists. One particular synthetic approach that emerged in the last decades is Umpolung: the normal polarity of chemical functio ...

EPFL2015

1-Alkynyltriazenes as Functional Analogues of Ynamides

Kay Severin, Rosario Scopelliti, Jérôme Waser, Gregor Kiefer, Loïc Nicolas Jeanbourquin, Florian Gérald Abela, Sophie Lucie Racine, Daniele Perrotta

The chemical reactivity of 1-alkynyltriazenes has been investigated and is found to parallel the reactivity of ynamides. The similarity in reactivity of these two classes of compounds is demonstrated by addition reactions with acids, by cycloaddition react ...

Wiley-Blackwell2015

Cyclopropanes and Hypervalent Iodine Reagents: High Energy Compounds for Applications in Synthesis and Catalysis

Davinia Fernández González, Jérôme Waser, Filippo De Simone, Jonathan Brand, Stefano Nicolai

One of the major challenges faced by organic chemistry is the efficient synthesis of increasingly complex molecules. Since October 2007, the Laboratory of Catalysis and Organic Synthesis (LCSO) at EPFL has been working on the development of catalytic react ...

2011

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

Davinia Fernández González, Jérôme Waser, Jonathan Brand, Stefano Nicolai

In the last decades, hypervalent iodine reagents have raised from chemical curiosities to mainstream reagents in organic synthesis. The use of benziodoxole-derived reagents has been especially successful in oxidation methods, whereas non-cyclic iodinanes h ...

Royal Society of Chemistry2011

Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions

Davinia Fernández González, Jérôme Waser, Jonathan Brand, Stefano Nicolai

Royal Society of Chemistry2011

Discovery and Analysis of Novel Metabolic Pathways for the Biosynthesis of Industrial Chemicals: 3-Hydroxypropanoate

Vassily Hatzimanikatis

Sustainable microbial production of high-value organic compounds such as 3-hydroxypropanoate (3HP) is becoming an increasingly attractive alternative to organic syntheses that utilize petrochemical feedstocks. We applied the Biochemical Network Integrated ...

Wiley-Blackwell2010

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