T2 mapping for the characterization of prostate lesions

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Background Rectal cancer segmentation in CT is crucial for timely diagnosis. Despite promising methods, challenges remain due to the rectum’s complex anatomy and the lack of a comprehensive annotated dataset. Methods A total of 33,024 slice pairs from 398 ...

Somatic hypermutation in cancer has gained momentum with the increased use of tumour mutation burden as a biomarker for immune checkpoint inhibitors. Spontaneous deamination of 5-methylcytosine to thymine at CpG dinucleotides is one of the most ubiquitous ...

Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8 liquids per pa ...

The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...

In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin ...

The identification and segmentation of histological regions of interest can provide significant support to pathologists in their diagnostic tasks. However, segmentation methods are constrained by the difficulty in obtaining pixel-level annotations, which a ...

Background Currently, multi-parametric prostate MRI (mpMRI) consists of a qualitative T-2, diffusion weighted, and dynamic contrast enhanced imaging. Quantification of T-2 imaging might further standardize PCa detection and support artificial intelligence ...

Purpose: We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (P-31) magnetic resonance spectra. The flexibility and speed of the technique rival traditional least-square fitting methods, with the per ...

Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the gener ...

Reliable, low cost, and accessible drug monitoring systems for individualized healthcare, especially chemotherapy for malignant diseases like prostate cancer and AIDS, are highly desira-ble. This is even more critical for drugs like abiraterone and TFV, wi ...

This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT). Reduced NCOR2 expression significantly associates with shorter disease-free survival in patients ...

Prostate cancer (PCa) is one of the leading causes of death among men. Low-dose brachytherapy is an increasingly used treatment for PCa, which requires the implantation of tens of radioactive seeds. This treatment causes discomfort; these implants cannot b ...

In diffusion weighted imaging (DWI), the apparent diffusion coefficient (ADC) has been recognized as a useful and sensitive surrogate for cell density, paving the way for non-invasive tumor staging, and characterization of treatment efficacy in cancer. How ...

RNA sequencing has emerged as a promising approach in cancer prognosis as sequencing data becomes more easily and affordably accessible. However, it remains challenging to build good predictive models especially when the sample size is limited and the numb ...

Unexplored electrochemical behavior of abiraterone, a recent and widely used prostate cancer drug, in interaction with cytochrome P450 3A4 (CYP3A4) enzyme and multiwalled carbon nanotubes (MWCNTs) is investigated in this work. The results reported in this ...

Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent reversible neurological disorder characterized by impaired locomotion, cognition and urinary control with ventriculomegaly. Symptoms can be relieved with cerebrospinal fluid drainage, which mak ...

Nanowire based platforms are widely reported for sensing applications and for their potential in the bio-detection field. In the present work, memristive nanowire devices are implemented for label-free sensing in liquid samples as well as in dried samples ...

In time-to-event settings, the presence of competing events complicates the definition of causal effects. Here we propose the new separable effects to study the causal effect of a treatment on an event of interest. The separable direct effect is the treatm ...

For the first time memristive biosensors developed by the incorporation of scAbs (single-chain antibody fragments) enabling label-free detection of free Prostate Specific Antigen (fPSA) for early-stage detection of prostate cancer (PC) are reported. In add ...

Semiconductor nanowires are emerging as promising building blocks for biosensors enabling direct electrical detection of various biomolecules. In this framework, two-terminal Schottky-barrier silicon (Si) nanowire arrays that exhibit memristive electrical ...

T2 mapping for the characterization of prostate lesions

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Tuning vision foundation models for rectal cancer segmentation from CT scans

Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers

Weakly supervised joint whole-slide segmentation and classification in prostate cancer

Value of T-2 Mapping MRI for Prostate Cancer Detection and Classification

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Ultra Selective and Sensitive Electrochemical Detection of Anti-Cancer and Anti-Viral Drugs by Optimized Nano-Bio-Sensors

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles

Time-Dependent Diffusion MRI in Cancer: Tissue Modeling and Applications

A meta-learning approach for genomic survival analysis

Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes

Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis

Nano-fabricated memristive biosensors for biomedical applications with liquid and dried samples

Separable Effects for Causal Inference in the Presence of Competing Events

Memristive Biosensors based on Full-size Antibodies and Antibody Fragments

Study on the bio-functionalization of memristive nanowires for optimum memristive biosensors