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T2 mapping for the characterization of prostate lesions

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Publications associées (40)

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Study on the bio-functionalization of memristive nanowires for optimum memristive biosensors

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Ioulia Tzouvadaki

Semiconductor nanowires are emerging as promising building blocks for biosensors enabling direct electrical detection of various biomolecules. In this framework, two-terminal Schottky-barrier silicon (Si) nanowire arrays that exhibit memristive electrical ...

Royal Society of Chemistry2016

Label-Free Ultrasensitive Memristive Aptasensor

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki

We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study, an affinity-based technique ...

American Chemical Society2016

An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages

Christopher Chase Bolt

The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynami ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

The miR-96 and RAR gamma signaling axis governs androgen signaling and prostate cancer progression

Gerard Llimos Aubach

Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RAR gamma) are commonly reduced in prostate cancer (PCa). Therefore, we sought to establish the cellular and gene regulatory consequences of reduced RAR gamma expression, and determine ...

Springer2019

Interobserver variability study for daily cone beam computed tomography registration of prostate volumetric modulated arc therapy

Purpose. - This work evaluated the interobserver variability in cone beam computed tomography (CBCT) registration for prostate cancers treated with intensity-modulated radiotherapy. Material and methods. - Twelve technologists realized 286 CBCT/CT registra ...

Elsevier2015

Enhanced MR Image Classification Using Hybrid Statistical and Wavelets Features

Mohammad Khaja Nazeeruddin

Classification of brain tumor is one of the most vital tasks within medical image processing. Classification of images greatly depends on the features extracted from the image, and thus, feature extraction plays a great role in the correct classification o ...

2019

Memristive Biosensors for PSA-IgM Detection

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki

Prostate cancer is the most common cancer among men except for skin cancer, and the detection at early stages is crucial. In the present work, nanofabricated memristive biosensors are subjected to surface bio-modification targeting at prostate-specific ant ...

2015

Bio-functionalization study of Memristive- Biosensors for Early Detection of Prostate Cancer

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki

Silicon nanowires are reported for their application in bio sensing area and their potential in the detection of various biomolecules. In the present work, freestanding two-terminal Schottky-barrier silicon nanowire arrays exhibiting memristive behavior ar ...

2015

microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques

Sandro Carrara, Tugba Kilic

As being the most extensively studied, non-coding, evolutionary conserved, post-transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention among various disciplines due to their important roles in biological processes and link ...

2018

LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum

Sebastian Maerkl

Label-free biosensing based on metallic nano-particles supporting localized surface plasmon resonances (LSPR) has recently received growing interest (Anker, J. N., et al. Nat. Mater. 2008, 7, 442-453). Besides its competitive sensitivity (Yonzon, C. R., et ...

Amer Chemical Soc2014

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Douglas Hanahan, Mohammad Sadegh Saghafinia

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

2018

Assessment of the effect of haematocrit-dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast-enhanced MRI

Nathalie Just

The detection and prognosis of prostate cancer in its early stages are critically important. It is therefore essential to improve the existing dynamic contrast-enhanced MRI (DCE MRI) techniques commonly used for the assessment of the tumour vascular enviro ...

Wiley-Blackwell2011

Portable Memristive Biosensing System as Effective Point-of-Care Device for Cancer Diagnostics

Giovanni De Micheli, Sandro Carrara, Danilo Demarchi, Ioulia Tzouvadaki, Abuduwaili Tuoheti

Memristive biosensors have been proved as excellent candidates for ultrasensitive biosensing. In this work, a novel portable bio-detection system based on memristive biosensors is designed, developed and tested for providing a significantly fast, automatic ...

IEEE2018

Protein-binding microarray technology and ChIP-sequencing for the identification of novel targets of the human tumor suppressor AP2[alpha]

The mis-regulation of gene transcription in the living cell can be the cause of complex human diseases like cancer. One challenge of the post-genomic era of biomedical research is the development of in vitro techniques for the rapid and cost-effective anal ...

EPFL2009

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Mikaël Nils Sturny

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat ...

ELSEVIER SCI LTD2018

Characterization of cancer stem cell subpopulations from patient-derived xenografts of advanced prostate cancer

Markus Germann

Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial response, a fraction of cases manifest progression to castration-resistant prostate cancer. PCa recurrence is possibly due to androgen-independent cancer stem c ...

AMER ASSOC CANCER RESEARCH2018

Imaging of renal and prostate carcinoma with refractive index radiology

Giorgio Margaritondo

Having better edge enhancement and penetrating power, refractive index radiology is suitable for the imaging of weakly absorbing objects such as tissue specimens. In this study the potential of refractive index radiology was evaluated for the imaging of re ...

Wiley-Blackwell2007

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Freddy Radtke, Michel Aguet

Notch pathway is crucial for stem/progenitor cell maintenance, growth and differentiation in a variety of tissues. Using a transgenic cell ablation approach, we found in our previous study that cells expressing Notch1 are crucial for prostate early develop ...

2006

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Marijana Mionic Ebersold, Débora Bonvin

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Real-Time Treatment Planning Optimisation for Brachytherapy

Jean-Philippe Thiran, Rakesh Chawla

In this paper, we present an integrated system for real-time dose distribution calculation and treatment planning optimisation for brachytherapy of prostate cancer, with a special emphasis on the visual integration of the dosimetry and target images obtain ...

2005