Role of microRNAs in tumor-associated macrophages

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It is well-established that symptomatic cancers evade immune destruction by coalescing tumor microenvironments to suppress adaptive immunity. Additionally, mouse models of cervical and other cancers have revealed a capability of tumors to systemically indu ...

Once contact with a pathogen has occurred, it might be too late for the immune system to react. Here, we asked whether anticipatory neural responses might sense potential infections and signal to the immune system, priming it for a response. We show that p ...

Foundation models have become a powerful tool in single-cell transcriptomics, enabling broad generalization across tasks such as cell type annotation, data integration, and drug response prediction. Yet, most current models are trained predominantly on hea ...

Photobiomodulation (PBM) therapy, a non-invasive therapeutic approach utilizing red and near-infrared light at sub-thermal irradiances, presents significant potential in promoting angiogenesis and tissue repair. This study optimized PBM parameters and eval ...

To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between hum ...

Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...

The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...

Dendritic cells (DCs) are specialized myeloid cells with the ability to uptake, process, and present antigens to T lymphocytes. They also generate cytokine and chemokine gradients that regulate immune cell trafficking, activation, and function. Monocyte-de ...

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

Elevated peripheral blood and tumor-infiltrating neutrophils are often associated with a poor patient prognosis. However, therapeutic strategies to target these cells are difficult to implement due to the life-threatening risk of neutropenia. In a genetica ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Lung cancer is the leading cause of cancer-related deaths worldwide and the most common lung cancer subtype is lung adenocarcinoma (LUAD). Frequently mutated genes involve activating mutations in KRAS and loss of function mutations in TP53. LUADs primarily ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Mycobacterium Tuberculosis is a highly effective pathogen infecting nearly a third of the world's population. An M. tuberculosis infection starts when droplets containing bacteria enter an individual's lungs. The first host cells to contact the bacteria ar ...

Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

Curcuminoids and their complexes continue to attract attention in medicinal chemistry, but little attention has been given to their metabolic derivatives. Here, the first examples of (arene)Ru(II) complexes with curcuminoid metabolites, tetrahydrocurcumin ...

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been di ...

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

Role of microRNAs in tumor-associated macrophages

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HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine

Neural anticipation of virtual infection triggers an immune response

Abstract IA02: Cancer-specific foundation models: Friend or foe in healthcare AI?

Stimulating angiogenesis and post-ischemic tissue repair: Optimizing photobiomodulation parameters in vivo

Mimicking women’s endocrine milieu in mice for women’s health-related studies

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

The role of LRRK2 in lung adenocarcinoma

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

6-diazo-5-oxo-l-norleucine prodrugs

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy