ID4 regulates mammary gland development by suppressing p38MAPK activity

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Publications associées (31)

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Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Cathrin Brisken, Ayyakkannu Ayyanan, Jacques Rougemont, Marian Caikovski, Duje Buric

Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...

Wiley-Blackwell2015

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Queralt Vallmajó Martín

The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...

EPFL2019

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Marie Shamseddin

Breast cancer is the most commonly diagnosed cancer and the most common cause of cancer death among women. Hormones have been shown to have a key role in breast development and carcinogenesis. Repeated activation of progesterone receptor (PR) signaling as ...

EPFL2018

Endocrine hormones and local signals during the development of the mouse mammary gland

Cathrin Brisken, Dalya Ataca

Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...

Wiley-Blackwell2015

Oestrogen receptor alpha AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Cathrin Brisken, Georgios Sflomos, Valentina Scabia, Patrik Aouad, Ayyakkannu Ayyanan, Dalya Ataca, Stéphanie Cagnet

Oestrogen receptor alpha (ER alpha) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), ter ...

Nature Publishing Group2018

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Bruno Lemaitre, Jean Philippe Boquete, Zongzhao Zhai

Stem cell self-renewal and differentiation are coordinated to maintain tissue homeostasis and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus of cancer studies. However, the contribution of the differentiating stem cel ...

Nature Publishing Group2015

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Cathrin Brisken, Stéphanie Cagnet

AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...

Company of Biologists2017

Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium

Cathrin Brisken, Duje Buric

The mammary gland is the only organ to undergo most of its development after birth and therefore particularly attractive for studying developmental processes. In the mouse, powerful tissue recombination techniques are available that can be elegantly combin ...

2016

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

Caroline Dafflon, Jörg Hülsken

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...

Elsevier2015

Scleractinian coral morphogenesis : searching for stem cells and precursors of the skeletogenic calicodermis

Agathe Eliette Marie Lecointe

Metamorphosis is a crucial step in the life cycle of a scleractinian coral: The swimming coral larva, the planula, settles, and metamorphoses into a sessile calcifying primary polyp, which subsequently grows into an adult colony. Importantly, morphogenesis ...

EPFL2016

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

Andreas Eduard Moor

Aberrantly active Wnt signaling is the hallmark driver of colorectal cancer (CRC). Bcl9/9l proteins are components of the main transcriptional activation complex of canonical Wnt signaling and interact with beta-catenin via a highly conserved homology doma ...

EPFL2014