Friedhelm Christoph Hummel

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Objective. The literature investigating the effects of alpha oscillations on corticospinal excitability is divergent. We believe inconsistency in the findings may arise, among others, from the electroencephalography (EEG) processing for brain-state determi ...

Enhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompass ...

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-co ...

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially p ...

Task-specific training constitutes a core element for evidence-based rehabilitation strategies targeted at improving upper extremity activity after stroke. Its combination with additional treatment strategies and neurotechnologybased solutions could furthe ...

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player’s motivation by challenging, but also to ensure ...

Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain structures. These techniques show particular promise as treatment strategies for neuropsychiatric disorders in which deep brain structures ...

Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway an ...

Oscillatory activity in the cerebellum and linked networks is an important aspect of neuronal processing and functional implementation of behavior. So far, it was challenging to quantify and study cerebellar oscillatory signatures in human neuroscience due ...

Objective. Non-invasive brain stimulation (NIBS) offers therapeutic benefits for various brain disorders. Personalization may enhance these benefits by optimizing stimulation parameters for individual subjects. Approach. We present a computational pipeline ...

Understanding behavior requires datasets that capture humans while carrying out complex tasks. The kitchen is an excellent environment for assessing human motor and cognitive function, as many complex actions are naturally exhibited in kitchens from choppi ...

Homonymous hemianopia (HH), a common visual impairment resulting from occipital lobe lesions, affects a significant number of stroke survivors. Intensive perceptual training can foster recovery, possibly by enhancing surviving visual pathways. This study e ...

Visual motion discrimination involves reciprocal interactions in the alpha band between the primary visual cortex (V1) and mediotemporal areas (V5/MT). We investigated whether modulating alpha phase synchronization using individualized multisite transcrani ...

BACKGROUND AND PURPOSE: Structural brain networks possess a few hubs, which are not only highly connected to the rest of the brain but are also highly connected to each other. These hubs, which form a rich-club, play a central role in global brain organiza ...

Objective: Home-based non-invasive brain stimulation (NIBS) has been suggested as an adjunct treatment strategy for neuro-psychiatric disorders. There are currently no available solutions to direct and monitor correct placement of the stimulation electrode ...

Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. R ...

BACKGROUND:The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at the group level in clinical trials, many patients remain sev ...

Introduction The WHO estimates that each year 5 million people are left permanently disabled after stroke. Adjuvant treatments to promote the effects of rehabilitation are urgently needed. Cortical excitability and neuroplasticity can be enhanced by non-in ...

Every year in Europe 1.5 million patients suffer a new stroke. Despite the further developments in acute therapy with nationwide stroke units, thrombolysis, thrombectomy and post-acute neurorehabilitation, only a small proportion of patients recover to a s ...

Technology-aided interventions and assessments are at the base of personalized motor rehabilitation after stroke. In the AVANCER trial, the effects of a novel personalized neurotech intervention were assessed by using an instrumented Fugl-Meyer (FM) evalua ...

Friedhelm Christoph Hummel

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MEP and TEP features variability: is it just the brain-state?

Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

The effect of gamified robot-enhanced training on motor performance in chronic stroke survivors

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders

Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network

Mini-review: Transcranial Alternating Current Stimulation and the Cerebellum

Precision non-invasive brain stimulation: an in silico pipeline for personalized control of brain dynamics

EPFL-Smart-Kitchen-30 Collected data

Pathway-dependent Brain Stimulation Responses Indicate Motion Processing Integrity After Stroke

Enhancing visual motion discrimination by desynchronizing bifocal oscillatory activity

Disconnectomics of the Rich Club Impacts Motor Recovery After Stroke

Computer vision-based algorithm to sUppoRt coRrect electrode placemeNT (CURRENT) for home-based electric non-invasive brain stimulation

Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior

Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke

A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of transcranial direct current stimulation to the motor cortex after stroke (NETS): study protocol

The importance of neuronal networks for motor rehabilitation after a stroke

Robotic-Aided Training and Assessment of Upper Limb Muscle Coordination Following Stroke