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Friedhelm Christoph Hummel

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Related publications (88)

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Single session cross-frequency bifocal tACS modulates visual motion network activity in young healthy population and stroke patients

Michele Bevilacqua, Friedhelm Christoph Hummel, Estelle Emeline Raffin, Roberto Felipe Salamanca Giron, Sarah Bernardina Zandvliet, Pauline Menoud, Fabienne Windel, Lisa Aïcha Mireille Julie Fleury, Sarah Feroldi

Objective: This study investigates the impact of single-session, cross-frequency (Alpha-Gamma) bifocal transcranial alternating current stimulation (cf-tACS) to the cortical visual motion network on inter-areal coupling between the primary visual cortex (V ...

2024

Non-invasive Cerebellar Stimulation: a Promising Approach for Stroke Recovery?

Friedhelm Christoph Hummel, Maximilian Jonas Wessel

Non-invasive brain stimulation (NIBS) combined with behavioral training is a promising strategy to augment recovery after stroke. Current research efforts have been mainly focusing on primary motor cortex (M1) stimulation. However, the translation from pro ...

2018

The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study

Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Laurijn Rianne Draaisma

Background: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation ...

2019

Toward precision medicine: tailoring interventional strategies based on noninvasive brain stimulation for motor recovery after stroke

Friedhelm Christoph Hummel, Philipp Johannes Koch

Purpose of reviewTo support the recovery of disability and the reduced functional capacity influencing the independence of daily life after focal brain lesions like stroke, the application of noninvasive brain stimulation (NIBS) by repetitive transcranial ...

Lippincott Williams & Wilkins2017

Brain Oscillatory Modes as a Proxy of Stroke Recovery

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Nathalie Heidi Meyer, Elena Beanato, Julia Brügger, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Giorgia Giulia Evangelista, Andéol Geoffroy Cadic-Melchior, Martino Bruno Armando Ceroni, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

Background Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery is ...

SAGE Publications2025

Reward boosts reinforcement-based motor learning

Friedhelm Christoph Hummel, Pierre Theopistos Vassiliadis

Besides relying heavily on sensory and reinforcement feedback, motor skill learning may also depend on the level of motivation experienced during training. Yet, how motivation by reward modulates motor learning remains unclear. In 90 healthy subjects, we i ...

Cell Press2021

Sensory capability and information integration independently explain the cognitive status of healthy older adults

Friedhelm Christoph Hummel

While there is evidence that sensory processing and multisensory integration change with age, links between these alterations and their relation to cognitive status remain unclear. In this study, we assessed sensory thresholds and performance of healthy yo ...

Nature Research2020

Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial

Friedhelm Christoph Hummel

Background Each year, five million people are left disabled after stroke. Upper -extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trial ...

Elsevier2024

Designing Configurable Arm Rehabilitation Games: How Do Different Game Elements Affect User Motion Trajectories?

Pierre Dillenbourg, Thibault Lucien Christian Asselborn, Ayberk Özgür, Arzu Güneysu Özgür, Wafa Monia Benkaouar Johal, Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Jennifer Kaitlyn Olsen

For successful rehabilitation of a patient after a stroke or traumatic brain injury, it is crucial that rehabilitation activities are motivating, provide feedback and have a high rate of repetitions. Advancements in recent technologies provide solutions to ...

IEEE2019

Evaluation of a shortened version of the Action Research Arm Test (ARAT) for upper extremity function after stroke: The Mini-ARAT

Friedhelm Christoph Hummel, Lisa Aïcha Mireille Julie Fleury

Objectives (i) to create a shortened version of the Action Research Arm Test scale, (ii) to investigate its psychometric properties compared to the original scale and (iii) to externally validate it within an independent cohort. Design Prospective longitud ...

SAGE PUBLICATIONS LTD2022

MEP and TEP features variability: is it just the brain-state?

Sylvain Jean-François Harquel, Michele Bevilacqua, Claudia Bigoni, Friedhelm Christoph Hummel, Estelle Emeline Raffin, Andéol Geoffroy Cadic-Melchior

Objective. The literature investigating the effects of alpha oscillations on corticospinal excitability is divergent. We believe inconsistency in the findings may arise, among others, from the electroencephalography (EEG) processing for brain-state determi ...

Iop Publishing Ltd2024

Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol

Jean-Philippe Thiran, Roser Vinals Terres, Friedhelm Christoph Hummel, Takuya Morishita, Rémy Marc M Gardier, Fabienne Windel

Enhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompass ...

SPRINGER HEIDELBERG2022

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

Elena Beanato, Pablo Maceira Elvira, Esra Neufeld, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Chang-Hyun Park, Traian Popa, Pierre Theopistos Vassiliadis, Pauline Menoud, Fabienne Windel

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-co ...

Nature Portfolio2023

DELMEP: a deep learning algorithm for automated annotation of motor evoked potential latencies

Claudia Bigoni, Friedhelm Christoph Hummel

The analysis of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) is crucial in research and clinical medical practice. MEPs are characterized by their latency and the treatment of a single patient may require the characte ...

Nature Portfolio2023

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

Jian Wang, Friedhelm Christoph Hummel

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially p ...

2021

The effect of gamified robot-enhanced training on motor performance in chronic stroke survivors

Pierre Dillenbourg, Valérie Rita Madeleine Zufferey, Arzu Güneysu Özgür, Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Andéol Geoffroy Cadic-Melchior, Giulia Dominijanni, Barbara Bruno

Task-specific training constitutes a core element for evidence-based rehabilitation strategies targeted at improving upper extremity activity after stroke. Its combination with additional treatment strategies and neurotechnologybased solutions could furthe ...

ELSEVIER SCI LTD2022

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Pierre Dillenbourg, Ayberk Özgür, Arzu Güneysu Özgür, Louis Pierre Faucon, Pablo Maceira Elvira, Wafa Monia Benkaouar Johal, Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Andéol Geoffroy Cadic-Melchior

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player’s motivation by challenging, but also to ensure ...

2019

Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders

Friedhelm Christoph Hummel

Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain structures. These techniques show particular promise as treatment strategies for neuropsychiatric disorders in which deep brain structures ...

NATURE PORTFOLIO2024

Pathway and directional specificity of Hebbian plasticity in the cortical visual motion processing network

Michele Bevilacqua, Friedhelm Christoph Hummel, Estelle Emeline Raffin

Cortico-cortical paired associative stimulation (ccPAS), which repeatedly pairs single-pulse transcranial magnetic stimulation (TMS) over two distant brain regions, is thought to modulate synaptic plasticity. We explored its spatial selectivity (pathway an ...

2023

Impact of interhemispheric inhibition on bimanual movement control in young and old

Friedhelm Christoph Hummel, Takuya Morishita

Interhemispheric interactions demonstrate a crucial role for directing bimanual movement control. In humans, a well-established paired-pulse transcranial magnetic stimulation paradigm enables to assess these interactions by means of interhemispheric inhibi ...

SPRINGER2022