Publications de David Michael Suter

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Cell identity maintenance faces many challenges during mitosis, as most DNA-binding proteins are evicted from DNA and transcription is virtually abolished. How cells maintain their identity through division and faithfully re-initiate gene expression during ...

Assigning single cell transcriptomes to cellular lineage trees by lineage tracing has transformed our understanding of differentiation during development, regeneration, and disease. However, lineage tracing is technically demanding, often restricted in tim ...

The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewi ...

The level of a given protein is determined by the synthesis and degradation rates of its mRNA and protein. While several studies have quantified the contribution of different gene expression steps in regulating protein levels, these are limited by using eq ...

The control of eukaryotic gene expression is intimately connected to highly dynamic chromatin structures. Gene regulation relies on activator and repressor transcription factors (TFs) that induce local chromatin opening and closing. However, it is unclear ...

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill-suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in ...

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

Naïve epiblast cells in the embryo and pluripotent stem cells in vitro undergo developmental progression to a formative state competent for lineage specification. During this transition, transcription factors and chromatin are rewired to encode new functio ...

Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D sliding, hopping, or intersegmental transfer. TF-DNA interactions depen ...

David Michael Suter

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Orchestration of pluripotent stem cell genome reactivation during mitotic exit

Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

Gene expression flux analysis reveals specific regulatory modalities of gene expression

Individual transcription factors modulate both the micromovement of chromatin and its long-range structure

An out-of-equilibrium definition of protein turnover

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

ERK signalling eliminates Nanog and maintains Oct4 to drive the formative pluripotency transition

Transcription Factors and DNA Play Hide and Seek

Role of OCT4 in establishing and maintaining chromatin architecture during stem cell self-renewal

Individual activator and repressor transcription factors act as modulators of global chromatin mobility

Target search dynamics of Sox transcription factors