Publications de Stanisa Raspopovic

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Lower limb amputation (LLA) destroys the sensory communication between the brain and the external world during standing and walking. Current prostheses do not restore sensory feedback to amputees, who, relying on very limited haptic information from the st ...

Neuroprostheses based on electrical stimulation are becoming a therapeutic reality, dramatically improving the life of disabled people. They are based on neural interfaces that are designed to create an intimate contact with neural cells. These devices spe ...

Recent studies have shown that direct nerve stimulation can be used to provide sensory feedback to hand amputees. The intensity of the elicited sensations can be modulated using the amplitude or frequency of the injected stimuli. However, a comprehensive c ...

Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to aboveknee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue(1-4). The l ...

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Objective Hand amputation is a highly disabling event, which significantly affects quality of life. An effective hand replacement can be achieved if the user, in addition to motor functions, is provided with the sensations that are naturally perceived whil ...

Background:The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the process-ing of descending efferent neural signals recorded using peripheral neural interfaces ...

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

An implantable device for intrafascicular stimulation and/or sensing of a peripheral nerve, including a blocking element adapted for wrapping a nerve, comprising an access point and an exit point, and an electrode adapted to traverse the blocking element v ...

Direct stimulation of peripheral nerves with implantable electrodes successfully provided sensory feedback to amputees while using hand prostheses. Longevity of the electrodes is key to success, which we have improved for the polyimide-based transverse int ...

The control of upper limb neuroprostheses through the peripheral nervous system (PNS) can allow restoring motor functions in amputees. At present, the important aspect of the realtime implementation of neural decoding algorithms on embedded systems has bee ...

Restoration of touch after hand amputation is a desirable feature of ideal prostheses. Here, we show that texture discrimination can be artificially provided in human subjects by implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which ...

Current myoelectric prostheses allow transradial amputees to regain voluntary motor control of their artificial limb by exploiting residual muscle function in the forearm. However, the overreliance on visual cues resulting from a lack of sensory feedback i ...

Objective: To study motor cortex plasticity after a period of training with a new prototype of bidirectional hand prosthesis in three left trans-radial amputees, correlating these changes with the modification of Phantom Limb Pain (PLP) in the same period. ...

The development of more effective approaches for controlling dexterous hand prostheses is an important area of research currently addressed by several groups with the aim of improving the quality of life of amputees. It is particularly important to establi ...

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Hand loss is a highly disabling event that markedly affects the quality of life. To achieve a close to natural replacement for the lost hand, the user should be provided with the rich sensations that we naturally perceive when grasping or manipulating an o ...

Objective We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis. Methods A multimodal neurophysiological and neuroima ...

Stanisa Raspopovic

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Enhancing functional abilities and cognitive integration of the lower limb prosthesis

Framework for the Development of Neuroprostheses: From Basic Understanding by Sciatic and Median Nerves Models to Bionic Legs and Hands

Comparison of linear frequency and amplitude modulation for intraneural sensory feedback in bidirectional hand prostheses

Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Six-Month Assessment of a Hand Prosthesis with Intraneural Tactile Feedback

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Corrigendum: A Psychometric Platform to Collect Somatosensory Sensations for Neuroprosthetic Use (vol 3, 619280, 2021)

Intrafascicular electrode implant

Bringing sensation to prosthetic hands-chronic assessment of implanted thin-film electrodes in humans

Real-Time Neural Signals Decoding onto Off-the-Shelf DSP Processors for Neuroprosthetic Applications

Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

A closed-loop hand prosthesis with simultaneous intraneural tactile and position feedback

Cortical plasticity after hand prostheses use: Is the hypothesis of deafferented cortex "invasion" always true?

On the Use of Intraneural Transversal Electrodes to Develop Bidirectional Bionic Limbs

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Correction to : "Experimental Validation of a Hybrid Computational Model for Selective Stimulation Using Transverse Intrafascicular Multichannel Electrodes"

Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses

Brain reactions to the use of sensorized hand prosthesis in amputees