Publications de Stéphanie Lacour

Publications associées (122)

NeuralTree: A 256-Channel 0.227-mu J/Class Versatile Neural Activity Classification and Closed-Loop Neuromodulation SoC

Stéphanie Lacour, Mahsa Shoaran, Bingzhao Zhu, Uisub Shin, Alix Esther Anne Trouillet, Cong Ding, Emilie Cornelia Maria Revol, Yashwanth Sai Reddy Vyza

Closed-loop neural interfaces with on-chip machine learning can detect and suppress disease symptoms in neurological disorders or restore lost functions in paralyzed patients. While high-density neural recording can provide rich neural activity information ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Liquid electromigration in gallium-based biphasic thin films

Stéphanie Lacour, Hadrien Olivier Michaud

Liquid metals have recently gained interest as a material of choice for soft and stretchable electronic circuits, thanks to their virtually infinite mechanical failure strain and high electrical conductivity. Gallium-based thin films are obtained by deposi ...

2019

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Towards Mimicking Brain Mechanical Loads: Stretchable Microelectrode Arrays for Brain Spheroid Electrophysiology

Stéphanie Lacour, Ivan Furfaro, Eleonora Martinelli, Laurine Kolly, Camille Lucette Gabrielle Delgrange

Human neural spheroids, 3D cellular aggregates of neurons and glial cells, are a compelling biological model for studying neuronal communication in physiological and pathological conditions, such as neurodevelopment and traumatic brain injury (TBI), respec ...

FUNDACIO DE LA COMUNITAT VALENCIANA SCITO2024

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants

Stéphanie Lacour, Bernard Schneider, Ivan Furfaro, Frédéric Pierre Gérald Michoud, Valentina Marie Paggi

Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects. Optogenetic app ...

Wiley2025

Radiation Patterns of RF Wireless Devices Implanted in Small Animals: Unexpected Deformations Due to Body Resonance

Anja Skrivervik, Stéphanie Lacour, Mingxiang Gao, German Augusto Ramirez Arroyave, Kangling Wu, James Daniel Rosenthal

One challenge in designing RF wireless bioelectronic devices is the impact of the interaction between electromagnetic waves and host body tissues on far-field wireless performance. In this paper, we investigate a peculiar phenomenon of implantable RF wirel ...

2023

A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity

Silvestro Micera, Stéphanie Lacour, Edoardo D'Anna, Emanuele Formento, Sandra Gribi

Objective.Electrical stimulation is an effective method for artificially modulating the activity of the nervous system. However, current stimulation paradigms fail to reproduce the stochastic and asynchronous properties of natural neural activity. Here, we ...

2020

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Hermetic, Hybrid Multilayer, Sub-5µm-Thick Encapsulations Prepared with Vapor-Phase Infiltration of Metal Oxides in Conformal Polymers for Flexible Bioelectronics

Yves Leterrier, Stéphanie Lacour, Massimo Mariello, Kangling Wu

Reliable long-term function is crucial for flexible and soft bioelectronics. Mechanical defects and permeation of water molecules across the various device layers are the prime drivers of failure, and particularly in applications requiring continuous conta ...

2024

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Lucas Aurélien Jourdan, Yves Leterrier, Stéphanie Lacour, Grégoire Courtine, Ivan Furfaro, Claudia Kathe, Massimo Mariello, Lei Wang, Kangling Wu, Marion Bianca Cleusix, Kosuke Ayama

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Wiley-V C H Verlag Gmbh2024

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Olivier Didier Christian Rizzo, Silvestro Micera, Stéphanie Lacour, Florian Dylan Fallegger, Ivan Furfaro, Katia Galan, Valentina Marie Paggi

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Direct laser writing of electronically conductive microstructures within soft hydrogel substrates

Veronica Navello, Stéphanie Lacour, Esther Amstad, Outman Akouissi, Lorenzo Lucherini

Hydrogels have emerged as promising materials for bioelectronic interfaces due to their tissue-like properties and high-water content. However, conventional hydrogels often suffer from poor electrical conductivity and mechanical stability, limiting their p ...

2025

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Stéphanie Lacour, Nicolas Vachicouras, Florent-Valéry Coen

The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing to deaf patients by electrically stimulating the cochlear nucleus (CN) of the brainstem. Whether such stimulation activates one or the other of the CN's two major sub ...

SPRINGER2022

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Ileana Ozana Jelescu, Léonie Asboth, Ivan Furfaro, Claudia Kathe, Kyungjin Kim, Frédéric Pierre Gérald Michoud, Valentina Marie Paggi, Thomas Haynes Hutson, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Noaf Salah Ali Alwahab

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents

Stéphanie Lacour, Frédéric Pierre Gérald Michoud, Amélie Anne Guex

Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simulta ...

2016

Dimensional scaling of thin-film stimulation electrode systems in translational research

Stéphanie Lacour, Giuseppe Schiavone, Nicolas Vachicouras, Yashwanth Sai Reddy Vyza

Objective. Electrical stimulation of biological tissue is an established technique in research and clinical practice that uses implanted electrodes to deliver electrical pulses for a variety of therapies. Significant research currently explores new electro ...

2021

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat

Stéphanie Lacour, Ivan Rusev Minev, Katherine Marie Musick

A severe complication of spinal cord injury is loss of bladder function (neurogenic bladder), which is characterized by loss of bladder sensation and voluntary control of micturition (urination), and spontaneous hyperreflexive voiding against a closed sphi ...

American Association for the Advancement of Science2013

Thin Hydrogel-Elastomer Multilayer Encapsulation for Soft Electronics

Stéphanie Lacour, Aaron Powers Gerratt, Jennifer Mary Adrienne Alice Macron

In the exciting race to design and engineer biointegrated and body-like electronic systems, many efforts concentrate on the integration of hydrogels in electronic assemblies. The versatility of hydrogels chemistry combined with their tissue-mimicking prope ...

Wiley2019