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Nicolai Cramer

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Publications associées (117)

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Nicolai Cramer, Laetitia Marie Mélanie Souillart

The lactone motif is ubiquitous in natural products and pharmaceuticals. The Tishchenko disproportionation of two aldehydes, a carbonyl hydroacylation, is an efficient and atom-economic access to lactones. However, these reaction types are limited to the t ...

Wiley-Blackwell2014

Asymmetric Rhodium(I)-Catalyzed C-C Activations with Zwitterionic Bis-phospholane Ligands

Nicolai Cramer

The development of unconventional ligand scaffolds is an important aspect to alter reaction pathways of transition-metal-catalyzed reactions. The nature of the counterion of cationic metal complexes plays an important role in the catalyst reactivity. We he ...

Amer Chemical Soc2014

Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

Tanguy Jean Daniel Saget, Nicolai Cramer

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of hete ...

Amer Chemical Soc2013

A Tunable Class of Chiral Cp Ligands for Enantioselective Rhodium(III)-Catalyzed C-H Allylations of Benzamides

Baihua Ye, Nicolai Cramer

The lack of robust and tunable chiral versions of cyclopentadienyl (Cp) ligands hampers progress in the development of catalytic asymmetric versions of a myriad of reactions catalyzed by this ubiquitous ligand. Herein, we describe of a class of chiral Cp l ...

Amer Chemical Soc2013

Rhodium-Catalyzed Dynamic Kinetic Asymmetric Transformations of Racemic Allenes by the [3+2] Annulation of Aryl Ketimines

Nicolai Cramer, Duc Tran Ngoc

Wiley-VCH Verlag GmbH2013

Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel-Catalyzed Hydrocarbamoylations of Alkenes

Nicolai Cramer, Pavel Alexandrovich Donets

Chiral trivalent phosphorus species are the dominant class of ligands and the key controlling element in asymmetric homogeneous transition-metal catalysis. Here, novel chiral diaminophosphine oxide ligands are described. The arising catalyst system with ni ...

Amer Chemical Soc2013

Enantioselective C-H Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters

Tanguy Jean Daniel Saget, Nicolai Cramer

Wiley-VCH Verlag GmbH2013

Heteroatom Nucleophile Induced C-C Fragmentations to Access Functionalized Allenes

Tanguy Jean Daniel Saget, Nicolai Cramer

The rich structural and reactivity profile of allenes render them versatile synthetic intermediates. However, application of allenes in organic chemistry is often attenuated by inconvenient methods of preparation. Herein we present an operationally simple ...

2012

Chiral Monodentate Trialkylphosphines Based on the Phospholane Architecture

Tanguy Jean Daniel Saget, Nicolai Cramer, Pavel Alexandrovich Donets

The development of efficient chiral monodentate phosphine ligands lags behind that of the bidentate congeners. This holds especially true for highly electron rich chiral phosphine analogues able to replace the ubiquitous tricyclohexylphosphine and tri-tert ...

Amer Chemical Soc2012

Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization

Baihua Ye, Nicolai Cramer

Metal complexes coordinated by a single cyclopentadienyl (Cp) ligand are widely used, versatile catalysts, but their application to asymmetric reactions has been hindered by the difficulty of designing Cp substituents that effectively bias the coordination ...

American Association for the Advancement of Science2012

Teaching Enantioselectivity to C-H Bond Functionalizations: Initial Steps of a Rather Long Shot

Nicolai Cramer

The direct functionalization of non-activated C-H bonds, especially in an enantioselective manner, requires metal catalysts equipped with ligands with specifically designed properties. Examples for asymmetric C(sp(2))-H and C(sp(3))-H functionalizations us ...

Swiss Chemical Soc2012

Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)-H Functionalization

Tanguy Jean Daniel Saget, Nicolai Cramer, Sébastien José Lemouzy

Wiley-VCH Verlag GmbH2012

Access to Sultams by Rhodium(III)-Catalyzed Directed C-H Activation

Baihua Ye, Nicolai Cramer, Van Manh Pham

Wiley-VCH Verlag GmbH2012

Palladium(0)-Catalyzed Enantioselective C-H Arylation of Cyclopropanes: Efficient Access to Functionalized Tetrahydroquinolines

Tanguy Jean Daniel Saget, Nicolai Cramer

Wiley-VCH Verlag GmbH2012

Enantioselective Rhodium(I)-Catalyzed [3+2] Annulations of Aromatic Ketimines Induced by Directed C?H Activations

Nicolai Cramer, Duc Tran Ngoc

Triple selectivity: Highly substituted indenylamines can be obtained with high enantioselectivity by formal [3+2] additions of aryl ketimines with internal alkynes. These rhodium(I)-catalyzed processes proceed by selective C-H activation of one of the two ...

Wiley-VCH Verlag GmbH2011

Convenient Preparation of Tri-tert-butylphosphonium Tetrafluoroborate

Tanguy Jean Daniel Saget, Nicolai Cramer

The versatile tri-tert-butylphosphonium tetrafluoroborate ligand is prepared in a convenient, simple, and high-yielding procedure without the isolation of sensitive intermediates. ...

2011

Catalytic Asymmetric Functionalization of Inert Bonds and Synthesis of Bioactive Natural Products

Nicolai Cramer

The direct and enantioselective functionalization of inert bonds such as carbon-hydrogen and carbon-carbon is an emerging tool towards more sustainable and efficient synthetic methods. The individual activation pathways like concerted deprotonation metalat ...

2011

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