Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

Glutathione S-Transferase Protein Expression in Different Life Stages of Zebrafish (Danio rerio)

Kristin Schirmer, Alena Tierbach

2018

Interaction of silver nanoparticles with algae and fish cells: a side by side comparison

Renata Behra, Laura Sigg, Yang Yue, Kristin Schirmer, Xiaomei Li

Background: Silver nanoparticles (AgNP) are widely applied and can, upon use, be released into the aquatic environment. This raises concerns about potential impacts of AgNP on aquatic organisms. We here present a side by side comparison of the interaction ...

Biomed Central Ltd2017

Ultrathin Alumina Membranes as Scaffold for Epithelial Cell Culture from the Intestine of Rainbow Trout

Philippe Renaud, Songmei Wu, Kristin Schirmer, Carolin Drieschner

Permeable membranes are indispensable for in vitro epithelial barrier models. However, currently available polymer-based membranes are low in porosity and relatively thick, resulting in a limited permeability and unrealistic culture conditions. In this stu ...

Amer Chemical Soc2017

Cocaine Accumulation in Zebrafish Eyes Leads to Augmented Amplitudes in the Electroretinogram

Kristin Schirmer

2017

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters

Kristin Schirmer, Melis Muz, Anita Orsolya Hidasi, Kevin Thomas, Juliane Hollender

Growing concern about the adverse environmental and human health effects of a wide range of micropollutants requires the development of novel tools and approaches to enable holistic monitoring of their occurrence, fate and effects in the aquatic environmen ...

Elsevier Science Bv2017

Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish

Kristin Schirmer

Opioid drugs, such as morphine (MO), detected in aquatic environments worldwide, may harm fish due to their semi-persistence and ability to potently interact with molecular targets conserved across vertebrates. Here, we established a waterborne bacterial l ...

Elsevier Sci Ltd2017

Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

Kristin Schirmer, Anita Orsolya Hidasi

Synthetic glucocorticoids (GCs) are potential endocrine disrupting compounds that have been detected in the aquatic environment around the world in the low ng/L (nanomolar) range. GCs are used as immunosuppressants in medicine. It is of high interest wheth ...

Elsevier2017

Assessing The Bioaccumulation Potential Of Ionizable Organic Compounds: Current Knowledge And Research Priorities

Kristin Schirmer

The objective of the present study was to review the current knowledge regarding the bioaccumulation potential of ionizable organic compounds (IOCs), with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of I ...

Society of Environmental Toxicology and Chemistry Press2017

Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades and Current Status

Kristin Schirmer

The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unne ...

Wiley-Blackwell2016

Silver nanoparticle-protein interactions in intact rainbow trout gill cells

Renata Behra, Laura Sigg, Yang Yue, Kristin Schirmer

Upon contact with biota, nanoparticles can bind to proteins, which coat the nanoparticles and form a nanoparticle-protein corona. Knowledge of corona proteins is therefore important for a mechanistic understanding of how nanoparticles interact with biomole ...

Royal Soc Chemistry2016

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

Renata Behra, Laura Sigg, Yang Yue, Kristin Schirmer

While short-term exposures of vertebrate cells, such as from fish, can be performed in defined, serum-free media, long-term cultures generally require addition of growth factors and proteins, normally supplied with a serum supplement. However, proteins are ...

Taylor & Francis Ltd2016

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