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Kristin Schirmer

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Publications associées (91)

Limitations and Uncertainties of Acute Fish Toxicity Assessments Can Be Reduced Using Alternative Methods

Kristin Schirmer

Information about acute fish toxicity is routinely required in many jurisdictions for environmental risk assessment of chemicals. This information is typically obtained using a 96-hour juvenile fish test for lethality according to OECD test guideline (TG) ...

2021

Impact of wastewater on the microbial diversity of periphyton and its tolerance to micropollutants in an engineered flow-through channel system

Kristin Schirmer, Ahmed Tlili

Wastewater treatment plants (WWTPs) play an important role in retaining organic matter and nutrients but to a lesser extent micropollutants. Therefore, treated wastewater is recognized as a major source of multiple stressors, including complex mixtures of ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Toxic effects of substituted p-benzoquinones and hydroquinones in in vitro bioassays are altered by reactions with the cell assay medium

Kristin Schirmer, Urs von Gunten

Substituted para-benzoquinones and hydroquinones are ubiquitous transformation products that arise during oxidative water treatment of phenolic precursors, for example through ozonation or chlorination. The benzoquinone structural motive is associated with ...

PERGAMON-ELSEVIER SCIENCE LTD2021

In vitro acute toxicity assessment of tire tread particles using rainbow trout cell lines of gill and intestine

Florian Frédéric Vincent Breider, Kristin Schirmer, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) are generated by the abrasion of tires while driving, and recent questions were raised in regards to their potential contribution to microplastics released into the aquatic environment and their potential toxicological i ...

2021

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern

Kristin Schirmer, Jelena Petrovic

We developed phospho-ERK1/2 ELISA for human and rainbow trout liver cells, employing HepG2 and RTL-W1 cell lines as models. The assay was applied to detect changes in ERK1/2 activity for nine chemicals, added over a wide concentration range and time points ...

ELSEVIER2021

Predicting exposure concentrations of chemicals with a wide range of volatility and hydrophobicity in different multi-well plate set-ups

Julita Maria Stadnicka-Michalak, Kristin Schirmer

Quantification of chemical toxicity in small-scale bioassays is challenging owing to small volumes used and extensive analytical resource needs. Yet, relying on nominal concentrations for effect determination maybe erroneous because loss processes can sign ...

NATURE RESEARCH2021

Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway

Kristin Schirmer, Alena Tierbach

Zebrafish (Danio rerio) early life stages offer a versatile model system to study the efficacy and safety of drugs or other chemicals with regard to human and environmental health. This is because, aside from the well-characterized genome of zebrafish and ...

OXFORD UNIV PRESS2020

Characterization of the Mercapturic Acid Pathway, an Important Phase II Biotransformation Route, in a Zebrafish Embryo Cell Line

Kristin Schirmer, Alena Tierbach

In view of the steadily increasing number of chemical compounds used in various products and applications, high-throughput toxicity screening techniques can help meeting the needs of 21st century risk assessment. Zebrafish (Danio rerio), especially its ear ...

AMER CHEMICAL SOC2020

Extending the Concept of Predicting Fish Acute Toxicity In Vitro to the Intestinal Cell Line RTgutGC

Kristin Schirmer, Hannah Inka Schug, Jenny Maner

Testing chemicals for fish acute toxicity is a legal requirement in many countries as part of environmental risk assessment. To reduce the number of fish used, substantial efforts have been focused on alternative approaches. Prominently, the cell viability ...

2020

LC-APCI(-)-MS Determination of 1-Chloro-2,4-dinitrobenzene, a Model Substrate for Glutathione S-Transferases

Kristin Schirmer, Alena Tierbach

1-Chloro-2,4-dinitrobenzene (CDNB) is widely used as a model substrate for measuring the enzyme activity of glutathione S-transferases in toxicity studies and in studies focusing on the metabolic capacity of different test systems. To allow the quantificat ...

AMER CHEMICAL SOC2020

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Kristin Schirmer, Anze Zupanic

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...

AMER CHEMICAL SOC2020

Time- and concentration-dependent expression of immune and barrier genes in the RTgutGC fish intestinal model following immune stimulation

Yang Yue, Kristin Schirmer, Hannah Inka Schug

2019

Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482

Julita Maria Stadnicka-Michalak, Mélanie Fischer, Kristin Schirmer, Anze Zupanic

ELSEVIER SCI LTD2019

Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions

Kristin Schirmer, Jenny Maner

Humpback whales, like other polar wildlife, accumulate persistent organic pollutants. In Southern hemisphere populations, hexachlorobenzene (HCB) dominates the contaminant profiles. HCB is linked to a variety of health effects and is classified as a group ...

2019

Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system

Kristin Schirmer

Silver nanoparticle toxicity has been extensively studied in several vertebrate cells. Its correlation with cellular essential metal homeostasis, however, has largely been overlooked. In this study, we used a novel in vitro model of a fish enterohepatic sy ...

ROYAL SOC CHEMISTRY2019

Imidacloprid induces adverse effects on fish early life stages that are more severe in Japanese medaka (Oryzias latipes) than in zebrafish (Danio rerio)

Kristin Schirmer, Juliane Hollender

Neonicotinoids are widely used insecticides that have frequently been found in freshwater with concentrations ranging from ng to mu g/L. It is known that these compounds impact non-target invertebrates, such as bees and gammaridae, in terms of toxicity and ...

Pergamon-Elsevier Science Ltd2019

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Philippe Renaud, Kristin Schirmer, Carolin Drieschner, Sarah-Katharina Könemann

In this study we present the first fish-gut-on-chip model. This model is based on the reconstruction of the intestinal barrier by culturing two intestinal cell lines from rainbow trout, namely epithelial RTgutGC and fibroblastic RTgutF, in an artificial mi ...

2019

Intestinal Fish Cell Barrier Model to Assess Transfer of Organic Chemicals in Vitro: An Experimental and Computational Study

Kristin Schirmer, Hannah Inka Schug, Anze Zupanic, Jenny Maner

We studied the role of the fish intestine as a barrier for organic chemicals using the epithelial barrier model built on the rainbow trout (Oncorhynchus mykiss) intestinal cell line, RTgutGC and the newly developed exposure chamber, TransFEr, specifically ...

AMER CHEMICAL SOC2019

Improving a fish intestinal barrier model by combining two rainbow trout cell lines: epithelial RTgutGC and fibroblastic RTgutF

Philippe Renaud, Kristin Schirmer, Carolin Drieschner, Hannah Inka Schug

An in vitro model of the fish intestine is of interest for research and application in diverse fields such as fish physiology, aquaculture and chemical risk assessment. The recently developed epithelial barrier model of the fish intestine relies on the RTg ...

Springer2019

Lifetime extension of humpback whale skin fibroblasts and their response to lipopolysaccharide (LPS) and a mixture of polychlorinated biphenyls (Aroclor)

Kristin Schirmer

Springer2019

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