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Kristin Schirmer

Cette personne a quitté l’EPFL

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Publications associées (90)

Page 4 sur 5

Predicting Fish Acute Toxicity Using a Fish Gill Cell Line-Based Toxicity Assay

Kristin Schirmer

The OECD test guideline 203 for determination of fish acute toxicity requires substantial numbers of fish and uses death as an apical end point. One potential alternative are fish cell lines; however, several studies indicated that these appear up to sever ...

Amer Chemical Soc2013

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Kristin Schirmer, Julita Maria Stadnicka-Michalak

Quantification of chemical toxicity continues to be generally based on measured external concentrations. Yet, internal chemical concentrations have been suggested to be a more suitable parameter. To better understand the relationship between the external a ...

2012

Toxicity of silver nanoparticles to a fish gill cell line: Role of medium composition

Kristin Schirmer, Yang Yue

In aqueous solutions, silver nanoparticle (AgNP) behavior is affected by a variety of factors which lead to altered AgNP size and toxicity. Our research aims to explore the effect of media composition on citrate-coated AgNP (cit-AgNP) behavior and toxicity ...

Informa Healthcare2015

Predicting Adult Fish Acute Lethality with the Zebrafish Embryo: Relevance of Test Duration, Endpoints, Compound Properties, and Exposure Concentration Analysis

Kristin Schirmer

The zebrafish embryo toxicity test has been proposed as an alternative for the acute fish toxicity test, which is required by various regulations for environmental risk assessment of chemicals. We. investigated the reliability of the embryo test by probing ...

Amer Chemical Soc2012

Ultrathin Alumina Membranes as Scaffold for Epithelial Cell Culture from the Intestine of Rainbow Trout

Philippe Renaud, Songmei Wu, Kristin Schirmer, Carolin Drieschner

Permeable membranes are indispensable for in vitro epithelial barrier models. However, currently available polymer-based membranes are low in porosity and relatively thick, resulting in a limited permeability and unrealistic culture conditions. In this stu ...

Amer Chemical Soc2017

Silver Nanoparticle Effects on Stream Periphyton During Short-Term Exposures

Kristin Schirmer

Silver nanoparticles (AgNP) are increasingly used as antimicrobials in consumer products. Subsequently released into aquatic environments, they are likely to come in contact with microbial communities like periphyton, which plays a key role as a primary pr ...

Amer Chemical Soc2015

Moving Targets, Long-Lived Infrastructure, and Increasing Needs for Integration and Adaptation in Water Management: An Illustration from Switzerland

Kristin Schirmer, Janet Gordon Hering, Clare Robinson

2012

Importance of Toxicokinetics for lnterspecies Variation in Sensitivity to Chemicals

Kristin Schirmer

Interspecies variation in sensitivity to synthetic chemicals can be orders of magnitude large. Species traits causing the variation can be related to toxicokinetics (uptake, distribution, biotransformation, elimination) or toxicodynamics (interaction with ...

American Chemical Society2014

Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion

Luke Christopher Harris, Kristin Schirmer, Florian Frédéric Vincent Breider, Dominique Grandjean, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This ...

2022

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern

Kristin Schirmer

We developed phospho-ERK1/2 ELISA for human and rainbow trout liver cells, employing HepG2 and RTL-W1 cell lines as models. The assay was applied to detect changes in ERK1/2 activity for nine chemicals, added over a wide concentration range and time points ...

ELSEVIER2021

Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades and Current Status

Kristin Schirmer

The need for alternative approaches to the use of vertebrate animals for hazard assessment of chemicals and pollutants has become of increasing importance. It is now the first consideration when initiating a vertebrate ecotoxicity test, to ensure that unne ...

Wiley-Blackwell2016

Critical influence of chloride ions on silver ion-mediated acute toxicity of silver nanoparticles to zebrafish embryos

Kristin Schirmer

The toxicity of silver nanoparticles (AgNP) to aquatic organisms, including zebrafish (Danio rerio), has been demonstrated, but differing opinions exist on the contribution of the physical properties of the particles themselves and the free dissolved silve ...

Informa Healthcare2015

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

Kristin Schirmer, Yang Yue

While short-term exposures of vertebrate cells, such as from fish, can be performed in defined, serum-free media, long-term cultures generally require addition of growth factors and proteins, normally supplied with a serum supplement. However, proteins are ...

Taylor & Francis Ltd2016

Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?

Kristin Schirmer

The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesti ...

Oxford University Press2014

Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482

Kristin Schirmer, Julita Maria Stadnicka-Michalak

ELSEVIER SCI LTD2019

Biotransformation of Benzo[a]pyrene by Three Rainbow Trout (Onchorhynchus mykiss) Cell Lines and Extrapolation To Derive a Fish Bioconcentration Factor

Kristin Schirmer, Julita Maria Stadnicka-Michalak

2018

Nanomaterials in the environment: Behavior, fate, bioavailability, and effectsAn updated review

Kristin Schirmer

2018

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters (vol 601, pg 1849, 2017)

Kristin Schirmer, Anita Orsolya Hidasi

2018

Advanced oxidation processes for the degradation of CCL3 compounds: Assessment of the toxicity of transformation products

Urs von Gunten, Kristin Schirmer

Amer Chemical Soc2013

Evaluating environmental risk assessment models for nanomaterials according to requirements along the product innovation Stage-Gate process

Kristin Schirmer

2018