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Qian Wang

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Publications associées (225)

Stereoselective Total Synthesis of Eburnane-Type Alkaloids Enabled by Conformation-Directed Cyclization and Rearrangement

Cyril Piemontesi, Qian Wang, Jieping Zhu, Guang Li

Controlling the cis C20/C21 relative stereochemistry remains an unsolved issue in the synthesis of eburnane-type indole alkaloids. Provided herein is a simple solution to this problem by developing a unified and diastereoselective synthesis of four represe ...

Wiley-VCH Verlag GmbH2019

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles

Qian Wang, Jieping Zhu, Sheng-Cai Zheng

We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3-arylpyrroles. Reaction of a-isocyanoacetates with b-aryl-a,b-alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkalo ...

Wiley-VCH Verlag GmbH2019

Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters

Qian Wang, Jieping Zhu, Hua Wu

The development of enantioselective pinacol rearrangement is extremely challenging due to the likelihood involvement of the carbenium intermediate that renders the stereochemical communication between catalyst and substrate difficult to achieve. Herein, we ...

2019

Catalytic Enantioselective α-Ketol Rearrangement

Qian Wang, Jieping Zhu, Hua Wu, Rémi Julien Sylvain Andres

A highly enantioselective a-ketol rearrangement has been developed. In the presence of a chiral Cu-bisoxazoline complex, achiral b-hydroxy-a-dicarbonyls were isomerized to chiral a-hydroxy-b-dicarbonyls and their bicyclic derivatives in excellent yields an ...

Wiley-VCH Verlag GmbH2019

Catalytic Kinetic Resolution by Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction into Enantioenriched 3-Arylpyrroles

Qian Wang, Jieping Zhu, Sheng-Cai Zheng

Racemic 3,4-dihydro-2H-pyrroles, hypothetical intermediates of the Barton–Zard reaction, were synthesized in a highly diastereoselective manner and fully characterized for the first time. Kinetic resolution of the dihydropyrroles with a quinine-derived thi ...

Wiley-VCH Verlag GmbH2019

Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles

Qian Wang, Jieping Zhu, Xu Bao, Jacobus A.W. Jong

Reaction of substituted o-aminobenzyl chlorides with isocyanides in the presence of a weak base (NaHCO3) at room temperature afforded the diversely functionalized 2-aminoindoles in good to excellent yields. A formal [4+1] cycloaddition of the in situ gener ...

Wiley-VHCA AG2019

Iron‐Catalysed Remote C(sp 3 )−H Azidation of O ‐Acyl Oximes and N ‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols

Qian Wang, Jieping Zhu, Alexandre Julien Florent Leclair

2019

Copper-Catalyzed Arylation of Remote C(sp3 )−H Bonds in Carboxamides and Sulfonamides

Qian Wang, Jieping Zhu, Zhaodong Li

Reported herein is an unprecedented copper-catalyzed arylation of remote C(sp3)-H bonds. Stirring a trifluorotoluene solution of either N fluorocarboxamides or N-fluorosulfonamides and arylboronic acids in the presence of a catalytic amount of copper(II) t ...

Wiley-VCH Verlag GmbH2018

Copper-catalyzed methylative difunctionalization of alkenes

Qian Wang, Jieping Zhu, Minh Tu Ha, Xu Bao, Takayuki Yokoe

Trifluoromethylative difunctionalization and hydrofunctionalization of unactivated alkenes have been developed into powerful synthetic methodologies. On the other hand, methylative difunctionalization of olefins remains an unexplored research field. We rep ...

Nature Research2018

From isonitrile to nitrile via ketenimine intermediate: Palladium-catalyzed 1,1-carbocyanation of ally carbonate by alpha-isocyanoacetate

David Savary, Qian Wang, Jieping Zhu, Charlotte Marie Sornay, Guanyinsheng Qiu, Sheng-Cai Zheng

A palladium-catalyzed 1,1-carbocyanation of allyl carbonate by alpha-quaternary alpha-isocyanoacetate was developed. Formation of ketenimine followed by homolysis of the C-N bond and recombination of the resulting caged radical pair was proposed to account ...

PERGAMON-ELSEVIER SCIENCE LTD2018

Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids

Qian Wang, Jieping Zhu, Zhengren Xu

From tryptamine and secologanine, nature generates monoterpene indole alkaloids with an unprecedented level of skeletal diversity through a ‘couple–divert’ sequence. Intrigued by this biosynthetic machinery, new strategies and tactics to access skeletally ...

Royal Society of Chemistry2018

Cooperative Pd/Cu Catalysis: Multicomponent Synthesis of Tetrasubstituted Imidazolones from Methyl α-Isocyanoacetates, Primary Amines, and Aryl(vinyl) Iodides

Qian Wang, Jieping Zhu, Antonin François Roland Clemenceau

2018

Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (−)-Mesembrane and (+)-Crinane

Qian Wang, Jieping Zhu, Xu Bao

Wiley-VCH Verlag GmbH2018

Copper-Catalyzed Enantioselective Arylative Desymmetrization of Prochiral Cyclopentenes with Diaryliodonium Salts

Qian Wang, Jieping Zhu, Hua Wu

Wiley-VCH Verlag GmbH2018

Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A

Qian Wang, Thomas Bertrand Pascal Marie Buyck, Jieping Zhu, Ruben Omar Torres Ochoa

Wiley-VCH Verlag GmbH2018

Chiral phosphoric acid-catalyzed enantioselective three-component Mannich reaction of acyclic ketones, aldehydes and anilines

Qian Wang, Jieping Zhu, Shuo Tong

2018

Sulfate adjustment for cement with triisopropanolamine: Mechanism of early strength enhancement

Qian Wang, Xuerun Li, Hong Huang, Hang Zhou

2018

Enantioselective total synthesis of (+)-Peganumine A

Cyril Piemontesi, Qian Wang, Jieping Zhu

AMER CHEMICAL SOC2018

Still Unconquered: Enantioselective Passerini and Ugi Multicomponent Reactions

Qian Wang, Jieping Zhu

2018

Non-intrusive reduced order modeling of unsteady flows using artificial neural networks with application to a combustion problem

Qian Wang, Jan Sickmann Hesthaven, Deep Ray

A non-intrusive reduced-basis (RB) method is proposed for parametrized unsteady flows. A set of reduced basis functions are extracted from a collection of high-fidelity solutions via a proper orthogonal decomposition (POD), and the coefficients of the redu ...

2018

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