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Georg Fantner

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Publications associées (87)

Large‐Range HS‐AFM Imaging of DNA Self‐Assembly through In Situ Data‐Driven Control

Alireza Karimi, Georg Fantner, Adrian Pascal Nievergelt, Christoph Manuel Kammer, Maartje Martina Cornelia Bastings, Charlène Cécile Geneviève Brillard, Eva Eugene Kurisinkal

Understanding hierarchical self-assembly of biological structures requires real time measurement of the self-assembly process over a broad range of length- and timescales. The success of high-speed atomic force microscopy (HS-AFM) in imaging small scale mo ...

2019

Detecting topological variations of DNA at single-molecule level

Aleksandra Radenovic, Georg Fantner, Ke Liu, Adrian Pascal Nievergelt

In addition to their use in DNA sequencing, ultrathin nanopore membranes have potential applications in detecting topological variations in deoxyribonucleic acid (DNA). This is due to the fact that when topologically edited DNA molecules, driven by electro ...

Nature Research2019

Time-Lapse Atomic Force Microscopy Reveals New End Take Off (Neto) Dynamics in Mycobacteria

Joëlle Xiao Yuan Ven, John McKinney, Georg Fantner, Adrian Pascal Nievergelt, Mélanie Thérèse Marie Hannebelle, Haig Alexander Eskandarian, Chiara Toniolo

CELL PRESS2019

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

Georg Fantner, Haig Alexander Eskandarian

The major facilitator superfamily transporter Rv1410 and the lipoprotein LprG (Rv1411) are encoded by a conserved two-gene operon and contribute to virulence in Mycobacterium tuberculosis. Rv1410 was originally postulated to function as a drug efflux pump, ...

2019

Single-molecule kinetics of pore assembly by the membrane attack complex

Georg Fantner, Adrian Pascal Nievergelt

The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. The MAC is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little is known about th ...

Springer2019

High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6

Pierre Gönczy, Santiago Harald Andany, Georg Fantner, Adrian Pascal Nievergelt, Niccolo Banterle

The self-assembly of protein complexes is at the core of many fundamental biological processes1, ranging from the polymerization of cytoskeletal elements, such as microtubules2, to viral capsid formation and organelle assembly3. To reach a comprehensive un ...

2018

An integrator-differentiator TIA using a multi-element pseudo-resistor in its DC servo loop for enhanced noise performance

Jens Anders, Georg Fantner

In this paper, we present an integrator-differentiator transimpedance amplifier (TIA) featuring a multielement pseudo-resistor (MEPR) in the DC feedback path for improved noise performance in the presence of non-zero DC input currents. The presented protot ...

IEEE2018

A 0.1% THD, 1-M Omega to 1-G Omega Tunable, Temperature-Compensated Transimpedance Amplifier Using a Multi-Element Pseudo-Resistor

Jens Anders, Georg Fantner

2018

Air and Water-Stable n-Type Doping and Encapsulation of Flexible MoS2 Devices with SU8

Andras Kis, Georg Fantner, Nahid Hosseini, Dumitru Dumcenco, Yen-Cheng Kung

2018

An analog high-speed single-cycle lock-in amplifier for next generation AFM experiments

Jens Anders, Georg Fantner, Adrian Pascal Nievergelt

In this paper, we present a new architecture for analog amplitude demodulation in high-speed atomic force microscopy (AFM) applications. It features single-cycle capabilities and the possibility to work with elevated cantilever resonance frequencies up to ...

IEEE2018

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

John McKinney, Georg Fantner, Haig Alexander Eskandarian

In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual cr ...

ELIFE SCIENCES PUBLICATIONS LTD2018

Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells

John McKinney, Georg Fantner, Adrian Pascal Nievergelt, Haig Alexander Eskandarian, Charlène Cécile Geneviève Brillard

Imaging living cells by atomic force microscopy (AFM) promises not only high-resolution topographical data, but additionally, mechanical contrast, both of which are not obtainable with other microscopy techniques. Such imaging is however challenging, as ce ...

2018

Reducing uncertainties in energy dissipation measurements in atomic force spectroscopy of molecular networks and cell-adhesion studies

Quentin Antoine Marie Theillaud, Georg Fantner, Blake William Erickson, Soma Biswas, Samuel Mendes Leitão

Atomic force microscope (AFM) based single molecule force spectroscopy (SMFS) is a valuable tool in biophysics to investigate the ligand-receptor interactions, cell adhesion and cell mechanics. However, the force spectroscopy data analysis needs to be done ...

Nature Research2018

Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions

Vassily Hatzimanikatis, Louise Catherine Bryan, Georg Fantner, Pascal Damian Odermatt, Oliver Hantschel, Sandrine Madeleine Suzanne Georgeon, Beat Fierz, Sinan Kilic, Carolin Christine Lechner, Andreas Linus Bachmann, Daniel Robert Weilandt

Chromatin recruitment of effector proteins involved in gene regulation depends on multivalent interaction with histone post-translational modifications (PTMs) and structural features of the chromatin fiber. Due to the complex interactions involved, it is c ...

Oxford University Press (OUP)2017

Digitally controlled analog proportional-integral-derivative (PID) controller for high-speed scanning probe microscopy

Santiago Harald Andany, Georg Fantner, Maja Dukic Pjanic, Nahid Hosseini, Adrian Pascal Nievergelt, Chen Yang

Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback con ...

2017

Microfluidic bacterial traps for simultaneous fluorescence and atomic force microscopy

Oliver Peric, Georg Fantner, Jonathan David Adams, Mélanie Thérèse Marie Hannebelle

The atomic force microscope has become an established research tool for imaging microorganisms with unprecedented resolution. However, its use in microbiology has been limited by the difficulty of proper bacterial immobilization. Here, we have developed a ...

2017

Division site selection linked to inherited cell surface wave troughs in mycobacteria

Joëlle Xiao Yuan Ven, John McKinney, Neeraj Dhar, Georg Fantner, Pascal Damian Odermatt, Adrian Pascal Nievergelt, Mélanie Thérèse Marie Hannebelle, Haig Alexander Eskandarian

Cell division is tightly controlled in space and time to maintain cell size and ploidy within narrow bounds. In bacteria, the canonical Minicell (Min) and nucleoid occlusion (Noc) systems together ensure that division is restricted to midcell after complet ...

2017

Rise time reduction of thermal actuators operated in air and water through optimized pre-shaped open-loop driving

Georg Fantner, Nahid Hosseini, Tom Larsen

Electrothermal actuators have many advantages compared to other actuators used in micro-electro-mechanical systems (MEMS). They are simple to design, easy to fabricate and provide large displacements at low voltages. Low voltages enable less stringent pass ...

2017

A versatile atomic force microscope integrated with a scanning electron microscope

Georg Fantner

A versatile atomic force microscope (AFM), which can be installed in a scanning electron microscope (SEM), is introduced. The flexible design of the instrument enables correlated analysis for different experimental configurations, such as AFM imaging direc ...

2017

Data-Driven Controller Design for Atomic-Force Microscopy

Alireza Karimi, Georg Fantner, Adrian Pascal Nievergelt, Christoph Manuel Kammer

A novel method to design data-driven, fixed-structure controllers with H2 and H∞ performance objectives is presented. The control design problem is transformed into a convex optimization problem with linear matrix inequality constraints, which can be solve ...

2017

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