Publications de Suliana Manley

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Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological fun ...

SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS-6 ...

Multiplexed super -resolution imaging offers a route to spatial proteomics; however, time -efficient mapping of many protein species has been challenging. Two recent works in Cell highlight SUM -PAINT and FLASHPAINT, methods that leverage adaptor DNA stran ...

Protein polarization underlies differentiation in metazoans and in bacteria. How symmetric polarization can instate functional asymmetry remains elusive. Here, we show by super-resolution photo-activated localization microscopy and edgetic mutations that t ...

During the past decade, localization microscopy (LM) has transformed into an accessible, commercially available technique for life sciences. However, data processing can be challenging to the non-specialist and care is still needed to produce meaningful re ...

Mitochondria serve as energetic and signaling hubs of the cell: This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties oft ...

Suliana Manley

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Learning the rules of mitochondrial network dynamics using generative models

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells

Polyphosphate granule formation affects chromosome dynamics during starvation in the opportunistic human pathogen Pseudomonas aeruginosa

DNA-PAINT adaptors make for efficient multiplexing

Interferometric fluorescent super-resolution microscopy resolves 3D cellular nano-architecture

Functional dichotomy and distinct nanoscale assemblies of acell cycle-c ontrolled bipolar zinc-finger regulator

Multicolor Single-Particle Reconstruction of Protein Complexes

PALMsiever: a tool to turn raw data into results for single-molecule localization microscopy

High throughput 3D Palm Imaging Elucidates Mechanisms of Bacterial Cell Division

Defect engineering of 2D material for biosensing applications

Mitochondrial division geometry and fate

Mitochondrial Structure, Dynamics, and Physiology Light Microscopy to Disentangle the Network

Nanoscale Spatial Organization of Chromatin in its Cellular Context, from Telomeres to Hox

From "There's Plenty of Room at the Bottom" to Seeing What is Actually There

Event-driven acquisition for content-enriched microscopy

High-Throughput Super-Resolution Microscopy for Revealing Molecular Architecture

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

Putting super-resolution fluorescence microscopy to work

Voices Physics meets biology: The joining of two forces to further our understanding of cellular function