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Suliana Manley

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Publications associées (87)

Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size

Suliana Manley, Thaïs Reichler, Lina Carlini, Anna Archetti, Charlotte Sophia Floderer

Protein concentration gradients pattern developing organisms and single cells. In Schizosaccharomyces pombe rod-shaped cells, Pom1 kinase forms gradients with maxima at cell poles. Pom1 controls the timing of mitotic entry by inhibiting Cdr2, which forms s ...

2019

Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging

Aleksandra Radenovic, Suliana Manley, Anna Archetti, Evgenii Glushkov, Anton Stroganov

Super-resolution microscopies based on the localization of single molecules have been widely adopted due to their demonstrated performance and their accessibility resulting from open software and simple hardware. The PAINT method for localization microscop ...

Nature Research2019

Strategies for increasing the throughput of super-resolution microscopies

Suliana Manley, Dora Mahecic, Juliette Griffie

Fluorescence microscopy methods have been developed to circumvent the diffraction limit by exploiting nonlinearities in the interactions between light and fluorophores. Initially, these methods were up to orders of magnitude slower than standard microscopi ...

ELSEVIER SCI LTD2019

Waveguide-Based Platform for Large-FOV Imaging of Optically Active Defects in 2D Materials

Aleksandra Radenovic, Suliana Manley, Jean Camille Benjamin Comtet, Martina Lihter, Anna Archetti, Juan Francisco Gonzalez Marin, Evgenii Glushkov, Anton Stroganov, Vytautas Navikas, Mukeshchand Thakur

Single-molecule localization microscopy (SMLM) is a powerful tool that is routinely used for nanoscale optical imaging of biological samples. Recently, this approach has been applied to study optically active defects in two-dimensional (2D) materials. Such ...

AMER CHEMICAL SOC2019

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

Suliana Manley, Aleksandr Benke, Beat Fierz, Andrea Callegari, David Michael Suter, Christian Sieben

Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In higher eukaryotes, it remains unclear how the duration of TF binding to DNA relates to downstream tran ...

2019

EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains

Suliana Manley, Marco Mina, Kyle Michael Douglass, Elisa Oricchio, Natalya Katanayeva, Maria Christine Donaldson, Elena Battistello, Timo Henry René Rey, Stephanie Jocelyne Sungalee, Giovanni Ciriello, Daniele Tavernari

Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 L ...

2019

Autonomous illumination control for localization microscopy

Suliana Manley, Baptiste Romain Samuel Ottino, Kyle Michael Douglass, Marcel Stefko

Super-resolution fluorescence microscopy improves spatial resolution, but this comes at a loss of image throughput and presents unique challenges in identifying optimal acquisition parameters. Microscope automation routines can offset these drawbacks, but ...

OPTICAL SOC AMER2018

Super-resolution microscopy to decipher multi-molecular assemblies

Suliana Manley, Paul Guichard, Kyle Michael Douglass, Christian Sieben

2018

Constriction Rate Modulation Can Drive Cell Size Control and Homeostasis in C. crescentus

Suliana Manley, Seamus John Holden, Aster Louis K Vanhecke, Anna Archetti, Ambroise Justin Lambert, Felix Max Schaber

Rod-shaped bacteria typically grow first via sporadic and dispersed elongation along their lateral walls and then via a combination of zonal elongation and constriction at the division site to form the poles of daughter cells. Although constriction compris ...

2018

Polyphosphate granule formation affects chromosome dynamics during starvation in the opportunistic human pathogen Pseudomonas aeruginosa

Suliana Manley, Aster Louis K Vanhecke

AMER SOC CELL BIOLOGY2018

Multicolor single-particle reconstruction of protein complexes

Pierre Gönczy, Suliana Manley, Kyle Michael Douglass, Christian Sieben, Niccolo Banterle

Single-particle reconstruction (SPR) from electron microscopy (EM) images is widely used in structural biology, but it lacks direct information on protein identity. To address this limitation, we developed a computational and analytical framework that reco ...

2018

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Joachim Lingner, Suliana Manley, Verena Pfeiffer, Aleksandra Vancevska, Kyle Michael Douglass

Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigge ...

Cold Spring Harbor Laboratory2017

Single particle maximum likelihood reconstruction from superresolution microscopy images

Julia Gunzenhäuser, Suliana Manley

Point localization superresolution microscopy enables fluorescently tagged molecules to be imaged beyond the optical diffraction limit, reaching single molecule localization precisions down to a few nanometers. For small objects whose sizes are few times t ...

2017

Super-resolution imaging of multiple cells by optimized flat-field epi-illumination

Suliana Manley, Kyle Michael Douglass, Christian Sieben, Anna Archetti, Ambroise Justin Lambert

Biological processes are inherently multi-scale, and supramolecular complexes at the nanoscale determine changes at the cellular scale and beyond. Single-molecule localizationmicroscopy (SMLM)(1-3) techniques have been established as important tools for st ...

Nature Publishing Group2016

Nanoscale Spatial Organization of Chromatin in its Cellular Context, from Telomeres to Hox

Denis Duboule, Joachim Lingner, Suliana Manley, Verena Pfeiffer, Aleksandr Benke, Pierre Raymond Fabre, Aleksandra Vancevska, Kyle Michael Douglass

Cell Press2016

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy

Suliana Manley, Aleksandr Benke

Apoptosis plays a pivotal role in development and tissue homeostasis in multicellular organisms. Clustering of Bak proteins on the mitochondrial outer membrane is responsible for the induction of apoptosis by evoking a release of pro-apoptotic proteins fro ...

Nature Research2016

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Cédric Deluz, Mahé Cécile Raccaud, Suliana Manley, Marion Leleu, Aleksandr Benke, Andrea Callegari, David Michael Suter, Daniel Strebinger, Torgil Elias Friman

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

Functional dichotomy and distinct nanoscale assemblies of acell cycle-c ontrolled bipolar zinc-finger regulator

Suliana Manley, Seamus John Holden

Protein polarization underlies differentiation in metazoans and in bacteria. How symmetric polarization can instate functional asymmetry remains elusive. Here, we show by super-resolution photo-activated localization microscopy and edgetic mutations that t ...

Elife Sciences Publications Ltd2016

Influenza a Viruses use Multivalent Sialic Acid Clusters for Cell Binding and Receptor Activation

Suliana Manley, Christian Sieben

Cell Press2016

Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

Suliana Manley, Seamus John Holden

Although free-living and obligate intracellular bacteria are both polarized it is unclear whether the underlying polarization mechanisms and effector proteins are conserved. Here we dissect at the cytological, functional and structural level a conserved po ...

Elife Sciences Publications Ltd2016

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