Publications de Carlos Canto Alvarez

Publications associées (47)

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

PURPOSE OF REVIEW: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1alpha activity is not constant and can be finely tuned in r ...

2009

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Johan Auwerx, Carlos Canto Alvarez, Dongryeol Ryu, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Vincenzo Sorrentino

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...

Amer Assoc Advancement Science2016

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

Carlos Canto Alvarez, Jérome Feige, Lucie Camille Chanvillard

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD(+)) levels are hallmarks of skeletal muscle ageing and sarcopenia(1,2,3), but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary c ...

2024

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Carlos Canto Alvarez, Jérome Feige

Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD(+), but little is known about their contribution to endogenous NAD(+) turnover and muscle plasticity during skeletal muscle growth and remodeling. Usin ...

FRONTIERS MEDIA SA2022

Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis

Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...

2018

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Olivia Zanoletti, Jocelin Grosse, Fiona Hollis, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut, Ioannis Zalachoras

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

A Method to Monitor the NAD(+) Metabolome-From Mechanistic to Clinical Applications

Carlos Canto Alvarez

Nicotinamide adenine dinucleotide (NAD(+)) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD(+) also serves as a substrate for enzymes such as sirtuins, poly(ADP-ribose) polymerases (PARPs) and ADP-ribosyl cyclases. ...

MDPI2021

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

Loïc Dayon, Carlos Canto Alvarez

Mitochondria constantly undergo fusion and fission events, referred as mitochondrial dynamics, which determine mitochondrial architecture and bioenergetics. Cultured cell studies demonstrate that mitochondrial dynamics are acutely regulated by phosphorylat ...

CELL PRESS2021

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor

Carlos Canto Alvarez, Richardus Houtkooper

Objective: A decay in intracellular NAD(+) levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD(+) precursors can prevent, alleviate, or even reverse multiple metabolic complicati ...

2019

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Matthias Lütolf, Vincent Trachsel, Bart Deplancke, Nicola Vannini, Johan Auwerx, Pedro Romero, Carlos Canto Alvarez, Mukul Girotra, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Pernille Yde Rainer, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Joanna Ratajczak, Josefine Catharina Pedersen Tratwal, George Coukos, Sonja Giger, Shanti Rojas-Sutterlin, Yang Li

It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here w ...

CELL PRESS2019

Mitochondrial function in the brain links anxiety with social subordination

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Olivia Zanoletti, Fiona Hollis, Laura Lozano Montes

Dominance hierarchies are integral aspects of social groups, yet whether personality traits may predispose individuals to a particular rank remains unclear. Here we show that trait anxiety directly influences social dominance in male outbred rats and ident ...

National Academy of Sciences2015

Circadian Rhythms and Mitochondria: Connecting the Dots

Carlos Canto Alvarez, Miriam Valera Alberni

Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evi ...

FRONTIERS MEDIA SA2018

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Johan Auwerx, Carlos Canto Alvarez, Joanna Ratajczak

NAD(+) is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD(+) precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide ribosi ...

Nature Publishing Group2016

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Patrick Descombes, Carlos Canto Alvarez, Richardus Houtkooper, Joanna Ratajczak, Catherine Maclachlan, Wen Gao

Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes. Disturbances in mitochondrial architecture and mitochondrial fusion related genes are observed in situatio ...

American Diabetes Association2016

Mitochondrial Dynamics: Shaping Metabolic Adaptation

Carlos Canto Alvarez

Despite their classic bean-shaped depiction, mitochondria have very different aspects in each cell type. From long filamentous structures to punctuated small round organelles. These shapes can dynamically change in response to nutrients and in situations o ...

ELSEVIER ACADEMIC PRESS INC2018

Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic (3-cell failure

Carlos Canto Alvarez

Objective: Disturbances in NAD+ metabolism have been described as a hallmark for multiple metabolic and age-related diseases, including type 2 diabetes. While alterations in pancreatic (3-cell function are critical determinants of whole-body glucose homeos ...

ELSEVIER2022

NAD(+) Precursors: A Questionable Redundancy

Carlos Canto Alvarez

The last decade has seen a strong proliferation of therapeutic strategies for the treatment of metabolic and age-related diseases based on increasing cellular NAD(+) bioavailability. Among them, the dietary supplementation with NAD(+) precursors-classicall ...

MDPI2022

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Carlos Canto Alvarez, Pablo Jose Fernandez Marcos, Joanna Ratajczak

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...

Elsevier Science Bv2015

Calorie restriction: is AMPK a key sensor and effector?

Johan Auwerx, Carlos Canto Alvarez

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the abi ...

2011

Mfn2 is critical for brown adipose tissue thermogenic function

Carlos Canto Alvarez, Joanna Ratajczak, Miriam Valera Alberni

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondri ...

Wiley2017