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Tobias Kober

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Publications associées (151)

Accelerated T(2)Mapping of the Lumbar Intervertebral Disc Highly Undersampled K-Space Data for Robust T(2)Relaxation Time Measurement in Clinically Feasible Acquisition Times

Tobias Kober, Tom Hilbert, Michael Weber

Objectives T(2)mapping of the intervertebral disc (IVD) can depict quantitative changes reflecting biochemical change due to loss of glycosaminoglycan content. Conventional T(2)mapping is usually performed using a 2-dimensional multi-echo-spin echo sequenc ...

2020

CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis

Jonas Richiardi, Meritxell Bach Cuadra, Reto Meuli, Tobias Kober, Cristina Granziera, João Pedro Forjaco Jorge, Mario Joao Fartaria de Oliveira, Francesco La Rosa

The central vein sign (CVS) is an efficient imaging biomarker for multiple sclerosis (MS) diagnosis, but its application in clinical routine is limited by inter-rater variability and the expenditure of time associated with manual assessment. We describe a ...

2020

Model-informed machine learning for multi-component T2 relaxometry

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Elda Fischi Gomez, Cristina Granziera, Tom Hilbert, Muhamed Barakovic, Gian Franco Piredda, Erick Jorge Canales Rodriguez, Marco Pizzolato, Thomas Yu

Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...

2020

A step forward toward the fully automated assessment of the central vein sign

Tobias Kober

SAGE PUBLICATIONS LTD2020

Model-based super-resolution reconstruction of T-2 maps

Jean-Philippe Thiran, Reto Meuli, Mohammad Golbabaee, Tobias Kober, Tom Hilbert, Gian Franco Piredda, Wajiha Bano

Purpose High-resolution isotropic T-2 mapping of the human brain with multi-echo spin-echo (MESE) acquisitions is challenging. When using a 2D sequence, the resolution is limited by the slice thickness. If used as a 3D acquisition, specific absorption rate ...

Wiley2020

Quantitative brain relaxation atlases for personalized detection and characterization of brain pathology

Jean-Philippe Thiran, Reto Meuli, Guillaume Bonnier, Tobias Kober, Cristina Granziera, Tom Hilbert, Gian Franco Piredda

Purpose To exploit the improved comparability and hardware independency of quantitative MRI, databases of MR physical parameters in healthy tissue are required, to which tissue properties of patients can be compared. In this work, normative values for long ...

WILEY2020

Head motion measurement and correction using FID navigators

Tobias Kober, Maryna Volodimirivna Waszak

Purpose: To develop a novel framework for rapid, intrinsic head motion measurement in MRI using FID navigators (FIDnavs) from a multichannel head coil array. ...

WILEY2019

Clinical equivalence assessment of T2 synthesized pediatric brain magnetic resonance imaging

Tobias Kober, Tom Hilbert, Jocelyn Philippe

Background and purpose. - Automated synthetic magnetic resonance imaging (MRI) provides qualitative, weighted image contrasts as well as quantitative information from one scan and is well-suited for various applications such as analysis of white matter dis ...

MASSON EDITEUR2019

Fast model-based T-2 mapping using SAR-reduced simultaneous multislice excitation

Jean-Philippe Thiran, Gunnar Krüger, Tobias Kober, José Pedro Rebelo Ferreira Marques, Tom Hilbert

Purpose To obtain whole-brain high-resolution T-2 maps in 2 minutes by combining simultaneous multislice excitation and low-power PINS (power independent of number of slices) refocusing pulses with undersampling and a model-based reconstruction. Methods A ...

WILEY2019

Artificial Intelligence in Musculoskeletal Imaging: Review of Current Literature, Challenges, and Trends

Jonas Richiardi, Tobias Kober

Artificial intelligence (AI) has gained major attention with a rapid increase in the number of published articles, mostly recently. This review provides a general understanding of how AI can or will be useful to the musculoskeletal radiologist. After a bri ...

THIEME MEDICAL PUBL INC2019

Advantages of fluid and white matter suppression (FLAWS) with MP2RAGE compared with double inversion recovery turbo spin echo (DIR-TSE) at 7T

Tobias Kober

Cerebrospinal fluid (CSF) and white matter (WM) signal suppression techniques allow better visualization of both WM and gray matter (GM) lesions in such disorders as multiple sclerosis and epilepsy. Recently, a technique, FLuid And White matter Suppression ...

ELSEVIER IRELAND LTD2019

Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition

Bénédicte Marie Maréchal, Tobias Kober

Background Acute methanol poisoning leads to optic neuropathy and necrotic lesions of basal ganglia (BG) and subcortical white matter. Survivors of methanol poisoning exhibit long-term executive and memory deficits. Associations between brain volumetry par ...

WILEY2019

Personalized pathology maps to quantify diffuse and focal brain damage

Guillaume Bonnier, Tobias Kober, Elda Fischi Gomez, Cristina Granziera, Alexis Roche, Tom Hilbert

2019

Regional T-1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence

Tobias Kober

While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization-prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure change ...

WILEY2019

Automated Detection and Segmentation of Multiple Sclerosis Lesions Using Ultra-High-Field MP2RAGE

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Kieran O'Brien, Mario Joao Fartaria de Oliveira

Objectives The aim of this study was to develop a new automated segmentation method of white matter (WM) and cortical multiple sclerosis (MS) lesions visible on magnetization-prepared 2 inversion-contrast rapid gradient echo (MP2RAGE) images acquired at 7 ...

LIPPINCOTT WILLIAMS & WILKINS2019

Preserved regional cortical volumes in multiple sclerosis patients with minimal disability compared to healthy volunteers

Bénédicte Marie Maréchal, Tobias Kober

SAGE PUBLICATIONS LTD2019

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Giulio Gambarota, Tobias Kober

Introduction: The fluid and white matter suppression sequence (FLAWS) provides two T1-weighted co-registered datasets: a white matter (WM) suppressed contrast (FLAWS1) and a cerebrospinal fluid (CSF) suppressed contrast (FLAWS2). FLAWS has the potential to ...

ELSEVIER SCIENCE INC2019

Atlas-based tract damage mapping improves 4-year forecast of EDSS in multiple sclerosis

Reto Meuli, Tobias Kober, Veronica Lily Ravano

SAGE PUBLICATIONS LTD2019

Longitudinal analysis of white matter and cortical lesions in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Mario Joao Fartaria de Oliveira

Purpose: The goals of this study were to assess the performance of a novel lesion segmentation tool for longitudinal analyses, as well as to validate the generated lesion progression map between two time points using conventional and non-conventional MR se ...

2019

Patient respiratory-triggered quantitative T-2 mapping in the pancreas

Reto Meuli, Tobias Kober, Josefina Adriana Maria Bastiaansen, Tom Hilbert

Background Long acquisition times and motion sensitivity limit T-2 mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free-breathing. Purpose To test the feasibility of ...

2019

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