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Alessandra Griffa

Cette personne a quitté l’EPFL

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Publications associées (80)

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Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity

Lijing Xin, Alessandra Griffa, Songi Lim, Xinyu Liu

Aging involves complex processes that impact the structure, function, and metabolism of the human brain. Declines in both structural and functional integrity along with reduced local inhibitory tone in the motor areas, as indicated by reduced γ-aminobutyri ...

Wiley2024

Dynamic spatiotemporal patterns of brain connectivity reorganize across development

Patric Hagmann, Alessandra Griffa, Marie Schaer

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying wh ...

MIT PRESS2020

Resting-brain functional connectivity predicted by analytic measures of network communication

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa

6 The complex relationship between structural and functional connectivity, as measured by noninvasive imaging of the human brain, poses many unresolved challenges and open questions. Here, we apply analytic measures of network communication to the structur ...

National Academy of Sciences2014

Comparison of Deconvolution Software in 3D Microscopy: A User Point of View—Part 1

Alessandra Griffa, Daniel Sage

Deconvolution is an image restoration technique which improves image contrast, resolution and signal to noise ratio. In modern optical microscopy and biological research deconvolution is becoming a fundamental processing step which allows for better image ...

EMS2010

Exploring MEG brain fingerprints: Evaluation, pitfalls, and interpretations

Sélima Zahar, Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Enrico Amico, Ekansh Sareen

Individual characterization of subjects based on their functional connectome (FC), termed “FC fingerprinting”, has become a highly sought-after goal in contemporary neuroscience research. Recent functional magnetic resonance imaging (fMRI) studies have dem ...

2021

Automated analysis of single stem cells in microfluidic traps

Matthias Lütolf, Alessandra Griffa, Olivier Burri, Arne Seitz, Mukul Girotra, Stefan Kobel

We report a reliable strategy to perform automated image cytometry of single (non-adherent) stem cells captured in microfluidic traps. The method rapidly segments images of an entire microfluidic chip based on the detection of horizontal edges of microflui ...

2012

Intrahemispheric cortico-cortical connections of the human auditory cortex

Jean-Philippe Thiran, Reto Meuli, Patric Hagmann, Alessandra Griffa, Leila Cammoun, Leila Faiza Ben Hamida Cammoun, Stephanie Clarke

The human auditory cortex comprises the supratemporal plane and large parts of the temporal and parietal convexities. We have investigated the relevant intrahemispheric cortico-cortical connections using in vivo DSI tractography combined with landmark-base ...

Springer Heidelberg2015

Default mode network and the timed up and go in MCI: A structural covariance analysis

Alessandra Griffa

Background: The timed up and go (TUG) is a test used to assess mobility in older adults and patients with neurological conditions. This study aims to compare brain gray matter (GM) correlates and structural covariance networks associated with the TUG time ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Functional dynamic network connectivity differentiates biological patterns in the Alzheimer's disease continuum

Alessandra Griffa

Alzheimer's disease (AD) can be conceptualized as a network-based syndrome. Network alterations are linked to the molecular hallmarks of AD, involving amyloid-beta and tau accumulation, and consecutively neurodegeneration. By combining molecular and restin ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2025

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection (vol 153, 106104, 2023)

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca

PERGAMON-ELSEVIER SCIENCE LTD2023

A multi-scale probabilistic atlas of the human connectome

Meritxell Bach Cuadra, Patric Hagmann, Alessandra Griffa, Maxime Descoteaux

The human brain is a complex system that can be efficiently represented as a network of structural connectivity. Many imaging studies would benefit from such network information, which is not always available. In this work, we present a whole-brain multi-s ...

NATURE PORTFOLIO2022

Evidence for increased parallel information transmission in human brain networks compared to macaques and male mice

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Enrico Amico

Brain communication, defined as information transmission through white-matter connections, is at the foundation of the brain's computational capacities that subtend almost all aspects of behavior: from sensory perception shared across mammalian species, to ...

Nature Portfolio2023

XuvTools: free, fast and reliable stitching of large 3D datasets

Alessandra Griffa

Current biomedical research increasingly requires imaging large and thick 3D structures at high resolution. Prominent examples are the tracking of fine filaments over long distances in brain slices, or the localization of gene expression or cell migration ...

2009

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Jelle Tymen Christiaan Schrauwen, Michaël Unser, Nikolaos Stergiopoulos, Alessandra Griffa, Daniel Sage, Aristotelis Agianniotis

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Dynamic functional networks in idiopathic normal pressure hydrocephalus: Alterations and reversibility by CSF tap test

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic Normal Pressure Hydrocephalus (iNPH)-the leading cause of reversible dementia in aging-is characterized by ventriculomegaly and gait, cognitive and urinary impairments. Despite its high prevalence estimated at 6% among the elderlies, iNPH remain ...

Wiley2020

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework

Alessandra Griffa, Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez, Ilaria Ricchi

The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers. MRI, being non-invasive ...

SAGE Publications2025

Idiopathic normal pressure hydrocephalus: A sulcal morphometry approach to brain phenotype and clinical response

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic normal pressure hydrocephalus (iNPH), the leading cause of reversible dementia in older adults, is characterized by urinary incontinence, gait impairment, cognitive decline, and ventriculomegaly. Neuroradiological features rely on visual assessm ...

Elsevier BV2025

The Connectome Mapper: an open-source processing pipeline to map connectomes with MRI

Jean-Philippe Thiran, Patric Hagmann, Alessandro Daducci, Alessandra Griffa, Reto Meuli, Leila Cammoun, Leila Faiza Ben Hamida Cammoun, Alia Lemkaddem, Xavier Gigandet

Researchers working in the field of global connectivity analysis using diffusion magnetic resonance imaging (MRI) can count on a wide selection of software packages for processing their data, with methods ranging from the reconstruction of the local intra- ...

Public Library of Science2012

Comparison of Deconvolution Software: A User Point of View—Part 2

Alessandra Griffa, Daniel Sage

Deconvolution is an image processing technique that restores the effective object representation [3] [4], allowing to improve images analysis steps such as segmentation [1] or colocalization study [2]. We performed several deconvolution tests on different ...

EMS2010

Redox Dysregulation, Myelination Deficit and Dysconnectivity in Schizophrenia: A Translational Study in First Episode Patients and Experimental Models

Rolf Gruetter, Lijing Xin, Patric Hagmann, Alessandra Griffa

ELSEVIER SCIENCE INC2021