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Tamar Kohn

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Publications associées (102)

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Impact of virus aggregation on inactivation by peracetic acid and implications for other disinfectants

Tamar Kohn, Paolo Perona, Krista Rule Wigginton, Benoît Crouzy, Michael Jon Mattle

Viruses in wastewater and natural environments are often present as aggregates. The disinfectant dose required for their inactivation, however, is typically determined with dispersed viruses. This study investigates how aggregation affects virus inactivati ...

2011

UVC inactivation of dsDNA and ssRNA viruses in water: UV fluences and a qPCR-based approach to evaluate decay on viral infectivity

Tamar Kohn, Anna Carratala Ripolles

Disinfection by low-pressure monochromatic ultraviolet (UVC) radiation (253.7 nm) became an important technique to sanitize drinking water and also wastewater in tertiary treatments. In order to prevent the transmission of waterborne viral diseases, the an ...

Springer2014

Ammonia as an in-situ sanitizer: influence of virus genome type on inactivation

Tamar Kohn, Loïc Decrey

Treatment of human excreta and animal manure (HEAM) is key in controlling the spread of persistent enteric pathogens such as viruses. The extent of virus inactivation during HEAM storage and treatment appeared to vary with virus genome type, though the rea ...

American Society for Microbiology2016

Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation

Tamar Kohn, Shotaro Torii, Aleksandar Antanasijevic

The sensitivity of enteroviruses to disinfectants varies among genetically similar variants and coincides with amino acid changes in capsid proteins, although the effect of individual substitutions remains unknown. Here, we employed reverse genetics to inv ...

2024

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness

Tamar Kohn, Jeffrey David Jensen, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong, Hyunjin Shim

Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evo ...

Amer Chemical Soc2017

Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, part I: Priority list for environmental risk assessment of pharmaceuticals

Tamar Kohn, Chiara Perazzolo

Pharmaceuticals are substances designed to have a biological effect in humans. Their presence in the environment, especially in surface waters, is of increasing concern because of their potential risk to non-target species. A large number of pharmaceutical ...

Society of Environmental Toxicology and Chemistry Press2010

Comparative characterization of bronchial and nasal mucus reveals key determinants of influenza A virus inhibition

Tamar Kohn, Athanasios Nenes, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Walter Hugentobler, Céline Terrettaz, Frank William Charlton

Differentiated primary human respiratory epithelial cells grown at air-liquid interface have become a widely used cell culture model of the human conducting airways. These cultures contain secretory cells such as goblet and club cells, which produce and se ...

American Society for Microbiology2025

Health risks for sanitation service workers along a container-based urine collection system and resource recovery value chain

Tamar Kohn, Timothy R. Julian, Heather Nicole Bischel-Magnan

Container-based sanitation (CBS) within a comprehensive service system value chain offers a low-cost sanitation option with potential for revenue generation, but may increase microbial health risks to sanitation service workers. This study assessed occupat ...

2019

Early detection and surveillance of SARS-CoV-2 genomic variants in wastewater using COJAC

Tamar Kohn, Timothy R. Julian, Xavier Fernandez Cassi, Federica Cariti, Alex Tunas Corzon

The continuing emergence of SARS-CoV-2 variants of concern and variants of interest emphasizes the need for early detection and epidemiological surveillance of novel variants. We used genomic sequencing of 122 wastewater samples from three locations in Swi ...

2022

Seasonality of cyanobacteria and eukaryotes in Lake Geneva and the impacts of cyanotoxins on growth of the model ciliate Tetrahymena pyriformis

Paul Hugo Seguin, Tamar Kohn, Anna Carratala Ripolles

Toxic cyanobacteria are likely to be favored by global warming and other human impacts, posing significant threats to aquatic ecosystems. While cyanobacterial blooms in eutrophic lakes are widely investigated, the dynamics of cyanobacteria and the effects ...

Elsevier BV2025

Wastewater Reveals the Spatiotemporal Spread of SARS-CoV-2 in the Canton of Ticino (Switzerland) during the Onset of the COVID-19 Pandemic

Tamar Kohn

Wastewater-based epidemiology (WBE) has emerged as an effective tool for monitoring SARS-CoV-2 dynamics during the COVID-19 pandemic. Here, we add a spatial component to WBE and use it to investigate SARS-CoV-2 spread in the canton of Ticino during the ons ...

2022

Variability in Disinfection Resistance between Currently Circulating Enterovirus B Serotypes and Strains

Tamar Kohn, Simon Meister, Matthew Eric Verbyla

The susceptibility of waterborne viruses to disinfection is known to vary between viruses and even between closely related strains, yet the extent of this variation is not known. Here, different enteroviruses (six strains of coxsackievirus B5, two strains ...

2018

Inactivation kinetics and mechanisms of viral and bacterial pathogen surrogates during urine nitrification

Tamar Kohn, Heather Nicole Bischel-Magnan, Ariane Schertenleib

This paper assesses the inactivation performance and mechanisms in urine nitrification reactors using bacteria and bacteriophages as surrogates for human pathogens. Two parallel continuous-flow moving bed biofilm reactors (MBBRs) were operated over a two-m ...

Royal Soc Chemistry2015

Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike

Tamar Kohn, Athanasios Nenes, Aline Laetitia Schaub, Shannon Christa David

SARS-CoV-2, the causative agent of COVID-19, is predominantly transmitted by respiratory aerosol and contaminated surfaces. Recent studies demonstrated that aerosols can become acidic, and acidification has been proposed as decontamination method. Here, we ...

Springer Science and Business Media LLC2025

Inaktivierung von Viren im Wasser

Tamar Kohn

Durch Wasser übertragene, infektiöse Humanviren sind oft im Rohwasser präsent. Bereits die Ingestion einer kleinen Anzahl solcher Viren kann diverse Krankheiten wie Gastroenteritis und Atemwegserkrankungen oder Hepatitis auslösen. Es ist also wichtig, Vire ...

2018

Conserved specificity of extracellular wastewater peptidases revealed by multiplex substrate profiling by mass spectrometry

Tamar Kohn, Josephine Lederballe Meibom

Peptide-based chemicals are promising for numerous applications including home and personal care and medical treatments. To better understand and control the environmental fate of peptide-based chemicals, in-depth knowledge on the specificity of wastewater ...

Springer Science and Business Media LLC2025

Kinetics of inactivation of waterborne enteric viruses by ozone

Urs von Gunten, Tamar Kohn, Camille Wolf

Ozone is an effective disinfectant against all types of waterborne pathogens. However, accurate and quantitative kinetic data regarding virus inactivation by ozone is scarce, due to the experimental challenges associated with the high reactivity of ozone t ...

2018

A modeling approach to estimate the solar disinfection of viral indicator organisms in waste stabilization ponds and surface waters

Tamar Kohn, Michael Jon Mattle

Sunlight is known to be a pertinent factor governing the infectivity of waterborne viruses in the environment. Sunlight inactivates viruses via endogenous inactivation (promoted by absorption of UVB sunlight by the virus) and exogenous processes (promoted ...

Elsevier2016

On the cause of the tailing phenomenon during virus disinfection by chlorine dioxide

Andreas Rohatschek, Tamar Kohn, Anne Thérèse Sigstam, Qingxia Zhong

This study investigates the mechanisms underlying the deviation from Chick-Watson kinetics, namely a tailing curve, during the disinfection of viruses by chlorine dioxide (ClO2). Tailing has been previously reported, but is typically attributed to the deca ...

Elsevier2014

Removal of trace organic contaminants from wastewater by superfine powdered activated carbon (SPAC) is neither affected by SPAC dispersal nor coagulation

Tamar Kohn, Florence Bonvin, Loïc Decrey

Powdered activated carbon (PAC) is increasingly used as tertiary treatment for the removal of trace organic contaminants (TrOCs) from wastewater (WW). To enhance the sorption kinetics and capacity, the PAC particles can be milled down to super fine powdere ...

2020