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Hongxia Lei

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Publications associées (68)

A high-power RF switch for arterial spin labelling with a separate tagging coil

Rolf Gruetter, Hongxia Lei

International Society for Magnetic Resonance in Medicine2012

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Hongxia Lei, Cristina Ramona Cudalbu, Sharon Janssens, Lili Sun-Reimer

The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the ...

Ios Press2012

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

Evaluation of glial metabolic fluxes in vivo with [2-13C] acetate infusion in mouse brain by 1H-[13C] NMR spectroscopy

Bernard Lanz, Rolf Gruetter, Lijing Xin, Hongxia Lei

2011

Early Predictive Biomarkers for Lesion After Transient Cerebral Ischemia

Rolf Gruetter, Hongxia Lei

Background and Purpose—Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. Methods—We ...

2011

In Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by 1H-[13C] NMR Spectroscopy

Bernard Lanz, Rolf Gruetter, Lijing Xin, Hongxia Lei

2011

Effect of manganese chloride on the neurochemical profile of the rat hypothalamus

Rolf Gruetter, Hongxia Lei, Nathalie Just, Cristina Ramona Cudalbu

Manganese (Mn 2+)-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food intake and energy balance circulate through specific hypothalamic nuclei. The dehydration-induce ...

Nature Publishing Group2011

Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Hongxia Lei, Sharon Janssens, Lili Sun-Reimer

2011

High-resolution mapping of the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

2011

Neurochemical profile of the mouse hypothalamus using in vivo1H MRS at 14.1T

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

The hypothalamus plays an essential role in the central nervous system of mammals by among others regulating glucose homeostasis, food intake, temperature, and to some extent blood pressure. Assessments of hypothalamic metabolism using, e.g. 1H MRS in mous ...

Wiley-Blackwell2010

Influence of regional macromolecule baseline on the quantification of neurochemical profile in rat brain

Rolf Gruetter, Lijing Xin, Hongxia Lei

2010

Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex

Rolf Gruetter, Hongxia Lei

Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the ...

Wiley-Blackwell2010

Biochemical evidence for a significant blood-brain barrier for glucose in hypothalamus using the reversible Michaelis-Menten model

Rolf Gruetter, Hanne Frenkel, Hongxia Lei, Carole Poitry-Yamate

Wiley-Blackwell2009

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

Rolf Gruetter, Hongxia Lei

Evolution of the neurochemical profile consisting of 19 metabolites after 30 mins of middle cerebral artery occlusion was longitudinally assessed at 3, 8 and 24 h in 6 to 8 mu L volumes in the striatum using localized H-1-magnetic resonance spectroscopy at ...

Nature Publishing Group2009

Steady-State Brain Glucose Transport Kinetics Evaluated With A Four-Site Conformational Model

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei

Wiley-Blackwell2009

The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky. A leaky blood–brain barrier implies high tissue glucose levels and obviates a role for endo ...

Wiley-Blackwell2009

Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Carole Poitry-Yamate

Glucose supply from blood to brain occurs through facilitative transporter proteins. A near linear relation between brain and plasma glucose has been experimentally determined and described by a reversible model of enzyme kinetics. A conformational four-st ...

Frontiers Research Foundation2009

Identification of early metabolic markers of various degrees of ischemia in the mouse brain by localized H-1 magnetic resonance spectroscopy

Rolf Gruetter, Hongxia Lei

Nature Publishing Group2009

Minimization of Nyquist ghosting for echo-planar imaging at ultra-high fields based on a "negative readout gradient" strategy

Rolf Gruetter, Hongxia Lei, Nathalie Just, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques

Purpose: To improve the traditional Nyquist ghost correction approach in echo planar imaging (EPI) at high fields, via schemes based on the reversal of the EPI readout gradient polarity for every other volume throughout a functional magnetic resonance imag ...

Wiley-Blackwell2009

MRI/MRS of ischemic evolution in mouse brain at 14.1 Tesla

Rolf Gruetter, Hongxia Lei

Wiley-Blackwell2009

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