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Patrycja Nowak-Sliwinska

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Publications associées (61)

The chicken chorioallantoic membrane model in biology, medicine and bioengineering

Patrycja Nowak-Sliwinska

The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CA ...

Springer2014

Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)-Arene Complex

Rosario Scopelliti, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

A ruthenium(II)-arene complex with a perfluoroalkyl-ligand was found to display remarkable selectivity toward cancer cells. IC50 values on several cancer cell lines are in the range of 25-45 mu M, and no cytotoxic effect was observed on nontumorigenic (HEK ...

Amer Chemical Soc2014

In vivo measurement of tissue oxygenation by time-resolved luminescence spectroscopy: advantageous properties of dichlorotris(1, 10-phenanthroline)-ruthenium(II) hydrate

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Sandrine Gay, Patrycja Nowak-Sliwinska, Senthil Kumar Rajendran, Veronika Huntosova

Measuring tissue oxygenation in vivo is of interest in fundamental biological as well as medical applications. One minimally invasive approach to assess the oxygen partial pressure in tissue (pO(2)) is to measure the oxygen-dependent luminescence lifetime ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

Patrycja Nowak-Sliwinska

The endothelium plays a pivotal role in the progression of solid tumors and is considered a highly relevant target for therapy. However, it emerges that current clinical angiogenesis inhibitors that act through inhibition of tumor-derived growth factors ar ...

2013

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

Nature Publishing Group2013

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

Patrycja Nowak-Sliwinska

Heparan sulfate (HS), a long linear polysaccharide, is implicated in various steps of tumorigenesis, including angiogenesis. We successfully interfered with HS biosynthesis using a peracetylated 4-deoxy analogue of the HS constituent GlcNAc and studied the ...

Amer Chemical Soc2013

Photodynamic therapy for polypoidal choroidal vasculopathy

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with ...

Pergamon-Elsevier Science Ltd2013

Angiogenesis inhibition by the maleimide-based small molecule GNX-686

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

We investigated the anti-angiogenic properties of GNX-686, a newly identified maleimide-based small molecule. In vitro studies on HUVEC showed that GNX-686 inhibited cell growth with an ED50 of 20-25 mu M, while human HeLa tumor cells and non-transformed e ...

Elsevier2012

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

Anti-angiogenic treatment for exudative age-related macular degeneration: new strategies are underway

Patrycja Nowak-Sliwinska

Exudative age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the western world. Recent developments in the field yielded vascular endothelial growth factor (VEGF) targeted strategies that caused a revolution in th ...

2012

Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?

Patrycja Nowak-Sliwinska

Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...

2012

Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Hubert van den Bergh, Patrycja Nowak-Sliwinska

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism ...

2012

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Filippo Piffaretti, Cédric Xavier Paulou, Patrycja Nowak-Sliwinska, Anna Maria Novello

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

SPIE Society of Photo-optical Instrumentation Engineers2012

Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

Hubert van den Bergh, Georges Wagnières, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Angela Casini

The antimetastatic ruthenium (II) compounds [Ru(eta(6)-p-cymene)Cl-2(PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) and [Ru(eta(6)-toluene)Cl-2(PTA)] (RAPTA-T), as well as their analogues [Ru(eta(6)-p-cymene)Cl-2(DAPTA)] (DAPTA = (3,7-diacetyl-1, ...

2011

Study of the pO2-sensitivity of the dendrimeric and free forms of Pd-meso-tetra(4-carboxyphenyl)porphyrin, incorporated or not in chitosan-based nanoparticles

Hubert van den Bergh, Georges Wagnières, Peter Käuper, Patrycja Nowak-Sliwinska

The concentration of oxygen and its rate of consumption are important factors in certain medical treatments, such as radiotherapy and photodynamic therapy (PDT). Measuring the tissue concentration of oxygen or its partial pressure (pO2) can be achieved by ...

Schweizerische Chemische Gesellschaft2011

The Neovessel Occlusion Efficacy of 15(1)-hydroxypurpurin-7-lactone dimethyl ester induced with photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Siang Hui Lim

In this study, the photodynamic therapy (PDT) induced efficacy of a semi-synthesized analogue 151-hydroxypurpurin-7-lactone dimethyl ester or G2, in terms of chick chorioallantoic membrane blood vessel occlusion was evaluated in reference to verteporfin. E ...

Wiley-Blackwell2010

Errata: Processing of Fluorescence Angiograms for the Quantification of Vascular Effects Induced by Anti-angiogenic Agents in the CAM model (vol 79, pg 21, 2010)

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

Elsevier2010

Angiostasis-induced vascular normalization can improve photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

Birkhäuser-Verlag, Springer2010

Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The chicken embryo chorioallantoic membrane (CAM) is widely used as an in vivo model to study the vascular effects of angiogenesis modulating agents. The main goal of the present study was to develop and validate a quantitative method to characterize time- ...

Elsevier2010

In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Siang Hui Lim

To understand the effects of substitution patterns on photosensitizing the ability of boron dipyrromethene (BODIPY), two structural variations that either investigate the effectiveness of various iodinated derivatives to maximize the "heavy atom effect" or ...

American Chemical Society2010

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