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Patrycja Nowak-Sliwinska

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Related publications (61)

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Anticancer Organometallic Osmium(II)-p-cymene Complexes

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for the ...

Wiley-V C H Verlag Gmbh2015

Insulin Receptor Marks The Tumor Endothelium; Its Role During Tumor Angiogenesis And Angiostatic Treatment

Patrycja Nowak-Sliwinska

Karger2015

Consensus guidelines for the use and interpretation of angiogenesis assays

Michele De Palma, Patrycja Nowak-Sliwinska, George Coukos, Elizabeth Anne Allen

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that ...

2018

Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Wee Han Ang

The cytotoxicity of cisplatin (cDDP) is enhanced when co-administered with ethacrynic acid (EA), a glutathione S-transferase (GST) inhibito r. A Pt-lV EA conjugate containing a cDDP core and two axial ethacrynate ligands (compound 1) was shown to be an ex ...

2018

Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Following the identification of [Ru(eta(6)-p-cymene)Cl-2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of stru ...

Amer Chemical Soc2015

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies

Paul Joseph Dyson, Patrycja Nowak-Sliwinska

A series of arene ruthenium metalla-rectangles of general formula (eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver ...

Elsevier Science Sa2015

Finding The Optimal Balance: Vascular Modulation Prior To Chemo- Or Photodynamic Therapy In Cancer Treatment

Patrycja Nowak-Sliwinska

Karger2015

Anti-angiogenic properties of chlorambucil derivatives with fluorous and hydrocarbon appendages

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu, Andrea Brett Gasser

Chlorambucil (CLB) derivatives with long fluorous (referred to as 1 and 2) or hydrocarbon (3) chains have been evaluated in a series of in vitro and in vivo assays. In cell viability inhibition assays, both derivatives 2 and 3 show selective cytotoxicity t ...

Royal Society of Chemistry2016

Perfluorinated ruthenium(II) complexes with improved anti-angiogenic or anti-cancer activity

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Springer2014

Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)-Arene Complex

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

A ruthenium(II)-arene complex with a perfluoroalkyl-ligand was found to display remarkable selectivity toward cancer cells. IC50 values on several cancer cell lines are in the range of 25-45 mu M, and no cytotoxic effect was observed on nontumorigenic (HEK ...

Amer Chemical Soc2014

Drug Combination for Treatment of Proliferative Diseases

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

Angiogenesis inhibitory drug combination obtained according to a specific algorithm, preferably a FSC, in which an initial combination of drugs is iteratively adjusted. The drug combination according to the invention may advantageously comprise a RAPTA-C c ...

2017

Validation of the ICRF antenna coupling code RAPLICASOL against TOPICA and experiments

Telmo David Ribeiro Da Costa, Pedro Filipe Varela Saraiva, Olivier Sauter, Stefano Coda, Basil Duval, Timothy Goodman, Patrick Blanchard, Richard Pitts, Yves Martin, Javier García Hernández, Bruno Marchand, Duccio Testa, Jean-Marc Moret, Alessandro Pau, Federico Alberto Alfredo Felici, Roland Behn, Benoît Labit, Jan Horacek, Yann Camenen, Holger Reimerdes, Laurie Porte, Christian Gabriel Theiler, Marco Wischmeier, Marc Gruber, Alexander Karpushov, Antonio José Pereira de Figueiredo, Alberto Bottino, Emiliano Fable, Patrycja Nowak-Sliwinska, Doohyun Kim, Federico Nespoli, Antoine Pierre Emmanuel Alexis Merle, Andrea Scarabosio, Umar Sheikh, Wouter Vijvers, Matteo Fontana, Yanis Andrebe, Cristian Galperti, Haomin Sun, Joan Decker, Zhouji Huang, Ben McMillan, Cedric Kar-Wai Tsui, Diego Carnevale, Janir Nuno Ramos Antunes Da Cruz, Nicola Vianello, Cristian Sommariva, Pedro Andres Molina Cabrera, Anna Teplukhina, Hoang Bao Le, Kevin Henricus Annemarie Verhaegh, Jennifer Kaitlyn Olsen, Jose Vicente Sanchez Mut, Dávid Wágner, Jose Felix Vega Stavro, Lorenzo Anton-Louis Talà, Claudio Marini, Pamela Solange Valdés Undurraga, Wei Zhang, Lenke Horváth, Attila Bencze, Himank Anand, Dahye Choi, Andrea Salmi, Raffaele Tito D'Agnolo, Erwan Fabrice Koch, Hugo Antoine Georges Arnichand, Thomas Binderup Jensen, Allan Svejstrup Nielsen, Michael Oliver Reinke, Pierre Jacquot, Stefano Mattei, Daniel Molina Romero, Ana Susnjara, Anton Malygin, Mélanie Preynas, Thomas Riedl, Mateusz Gospodarczyk, Pascal Morel, Wen Bin Chng

In this paper we validate the finite element code RAPLICASOL, which models radiofrequency wave propagation in edge plasmas near ICRF antennas, against calculations with the TOPICA code. We compare the output of both codes for the ASDEX Upgrade 2-strap ante ...

IOP Publishing Ltd2019

Combination of low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy in human carcinoma models: lack of vascular normalization

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Débora Bonvin

Springer2014

Angiostasis-induced vascular normalization can improve photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

Birkhäuser-Verlag, Springer2010

Improved Angiostatic Activity of Dasatinib by Modulation with Hydrophobic Chains

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Dasatinib is an orally active nonselective tyrosine kinase inhibitor used to treat certain types of adult leukemia. By inhibiting PDGFR-beta and SFKs in both tumor cells and tumor associated endothelial cells, dasatinib inhibits tumor growth and angiogenes ...

Amer Chemical Soc2015

Light-activated sunitinib causes endothelial and vascular damage leading to tumor growth inhibition

Patrycja Nowak-Sliwinska, Andrea Brett Gasser

Springer2014

The Great Escape; the Hallmarks of Resistance to Antiangiogenic Therapy

Patrycja Nowak-Sliwinska

The concept of antiangiogenic therapy in cancer treatment has led to the approval of different agents, most of them targeting the well known vascular endothelial growth factor pathway. Despite promising results in preclinical studies, the efficacy of antia ...

Amer Soc Pharmacology Experimental Therapeutics2015

Ruthenium clusters as new class of anti-angiogenic agent

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Alexey Nazarov

Springer2014

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs with fluorous chains that are selectively triggered by mild hyperthermia ...

2014

Sequential combination of axitinib with photodynamic therapy synergistically delays tumor growth in a preclinical model of human ovarian carcinoma

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Débora Bonvin

Springer2014