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Patrycja Nowak-Sliwinska

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Publications associées (61)

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

Nature Publishing Group2015

Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes

Rosario Scopelliti, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Following the identification of [Ru(eta(6)-p-cymene)Cl-2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of stru ...

Amer Chemical Soc2015

A streamlined search technology for identification of synergistic drug combinations

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

Thermoresponsive fluorinated small-molecule drugs: a new concept for efficient localized chemotherapy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Hyperthermia is currently being explored as an adjuvant treatment to conventional therapies with chemotherapeutic agents based on thermoresponsive macromolecules. Although the concept of hyperthermia has existed for many years it has yet to become routinel ...

2015

The Great Escape; the Hallmarks of Resistance to Antiangiogenic Therapy

Patrycja Nowak-Sliwinska

The concept of antiangiogenic therapy in cancer treatment has led to the approval of different agents, most of them targeting the well known vascular endothelial growth factor pathway. Despite promising results in preclinical studies, the efficacy of antia ...

Amer Soc Pharmacology Experimental Therapeutics2015

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero

A series of arene ruthenium metalla-rectangles of general formula (eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver ...

Elsevier Science Sa2015

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

Discovery of a low order drug-cell response surface for applications in personalized medicine

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Yiyang Li

The cell is a complex system involving numerous components, which may often interact in a non-linear dynamic manner. Diseases at the cellular level are thus likely to involve multiple cellular constituents and pathways. As some drugs, or drug combinations, ...

Iop Publishing Ltd2014

Sequential combination of axitinib with photodynamic therapy synergistically delays tumor growth in a preclinical model of human ovarian carcinoma

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Débora Bonvin

Springer2014

Ruthenium clusters as new class of anti-angiogenic agent

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov

Springer2014

Combination of low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy in human carcinoma models: lack of vascular normalization

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Springer2014

Light-activated sunitinib causes endothelial and vascular damage leading to tumor growth inhibition

Patrycja Nowak-Sliwinska

Springer2014

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

2014

In vivo anti-tumor activity of the organometallic ruthenium(II)-arene complex [Ru(eta(6)-p-cymene)-Cl-2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

Paul Joseph Dyson, Maxime Dubois, Patrycja Nowak-Sliwinska

Based on the clinical success of platinum-based anti-cancer drugs such as cisplatin, carboplatin and oxaliplatin, a variety of other metal-based anti-cancer compounds are being investigated. In particular, a number of ruthenium-based compounds have been id ...

2014

Perfluorinated ruthenium(II) complexes with improved anti-angiogenic or anti-cancer activity

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Springer2014

Highly water soluble trithiolato-bridged dinuclear arene ruthenium complexes

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Noelia Claude Herrero

Water soluble arene-functionalised trithiolato-bridged ruthenium complexes of general formula (eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-SR)(3), where R = C6H5 (1), C6H4-p-OMe (2), C6H4-p-OMe (3), C6H4-p-Pr-i (4), C6H4-p-Bu-t (5), CH2C6H5 (6), CH2CH2C6H5 (7) an ...

Elsevier Science Sa2014

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs with fluorous chains that are selectively triggered by mild hyperthermia ...

2014

The emerging quest for the optimal angiostatic combination therapy

Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul

Angiostatic therapies are now routinely embedded in the daily clinical management of cancer. Although these agents clearly benefit patient survival rates, the effect is only moderate with sometimes considerable side effects. A major cause of failure in thi ...

Portland Press Ltd2014

A feedback loop optimized vascular targeted drug combination for the treatment of cancer

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska

Springer2014

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