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The invention provides an agent modulating the expression and/or activity of i) the POU5F1B protein, a fragment or variant thereof, ii) an mRNA encoding POU5F1B, a fragment or variant thereof and/or iii) the POU5F1B gene. Preferably, the agent is for use i ...

The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...

The invention provides anti-SARS-CoV-2 antibodies and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced sensitivity to vaccine-induced immunity. Here, we screen B cells ...

Resolving the DNA-binding specificities of transcription factors (TFs) is of critical value for understanding gene regulation. Here, we present a novel, semiautomated protein-DNA interaction characterization technology, selective microfluidics-based ligand ...

New technologies in life sciences are helping to revolutionize health management with the objective to move towards personalized healthcare. The Swiss Federal government is investing in multidisciplinary, countrywide initiatives such as Health 2030 to meet ...

Didier Trono

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Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease

Pou5f1b inhibitors

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease

Fluorescence-based promoter gene trap screen during mouse pre-implantation development

Potential Of Induced Pluripotent Stem Cells For The Treatment Of Crigler-Najjar Liver Disease

Regulated lentiviral vector gene transfer for X-CGD

Evolutionarily recent transposable elements and their controllers regulate human early embryonic transcriptional networks

The interplay between regulatory variants, transposable elements and gene expression in the context of colorectal cancer

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

A highly potent antibody effective against SARS-CoV-2 variants of concern

SMiLE-seq identifies binding motifs of single and dimeric transcription factors

Regulated Lentiviral Vector Gene Transfer For X-Cgd

Lentiviral vectors, two decades later

Switzerland and the Digital Health Revolution

Transposable element-driven transcripts as new cancer biomarkers

The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription