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The present invention provides a method for preparing a sequencing library from a ribonucleic acid (RNA) sample. ...

The present invention relates to a method for assessing the quality, utility and applicability of a cell according to the said method comprising the following steps: a) analyzing the expression of the TEs of said cell in order to set up an expression profi ...

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...

The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory network controlled by the KRAB z ...

Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological fun ...

The invention relates to methods for detecting or predicting the likelihood of a cancer in a subject as well as to compositions, pharmaceutical compositions and methods of treatment of cancer. ...

Mammalian genomes are a battleground for genetic conflict between repetitive elements and KRAB-zinc finger proteins (KZFPs). We asked whether KZFPs can regulate cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR. ZP3AR coats megabase reg ...

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our resu ...

Lentiviral delivery of glial cell line-derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of Parkinson's disease (PD). We injected lenti-GDNF into the striatum and ...

Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. To study effects of RPS19 deficiency in hematopoiesis we transduced CD34(+) umbilical cord blood (CB) and ...

Objectives This cohort study including essential workers, assessed the risk and incidence of SARS-CoV-2 infection during the second surge of COVID-19 according to baseline serostatus and occupational sector. Methods Essential workers were selected from a s ...

Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 an ...

IMPORTANCE There are limited comparative data on the durability of neutralizing antibody (nAb) responses elicited by messenger RNA (mRNA) vaccines against the SARS-CoV-2 variants of concern (VOCs) in immunocompromised patients and healthy controls. ...

Didier Trono

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DPPA2 and DPPA4 regulate expression of Dux in mouse embryonic stem cells

Construction of sequencing libraries from a ribonucleic acid (rna) using tailing and ligation of cdna (tlc)

Method for assessing the quality of various cells including induced pluripotent stem cells

DUX is a non-essential synchronizer of zygotic genome activation

New ingredients for old recipes

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

Transpochimeric gene trancripts (tcgts) as cancer biomarkers

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Machine Learning in Protein Science De Novo Design of Site-Specific Protein Binders Using Surface Fingerprints

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

Control of mitophagie by microRNAs - A key step of erythropoiesis

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Dual-Regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatous Disease

Dual-regulated lentiviral vector for gene therapy of x-linked chronic granulomatous disease

Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients

PAX5 as a model to study the evolution of transcription factors' regulatory networks

KRAB-ZFPs and transposable elements rewire early human embryonic development transcriptional networks