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Rolf Gruetter

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Publications associées (418)

An improved trap design for decoupling multinuclear RF coils

Eulalia Serés Roig, Rolf Gruetter

Purpose Multinuclear magnetic resonance spectroscopy and imaging require a radiofrequency probe capable of transmitting and receiving at the proton and non-proton frequencies. To minimize coupling between probe elements tuned to different frequencies, LC ( ...

Wiley-Blackwell2014

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Purely endogenous hyperpolarized [1-13C]Pyruvate solutions for metabolic study in glioblastoma rat models

Arnaud Comment, Rolf Gruetter, Mor-Miri Mishkovsky, Tim Rolf Eichhorn, Emine Can

2014

Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

The recent developments in high magnetic field (13) C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of (13) C in vivo spectra in the rodent brain, enabl ...

Wiley-Blackwell2013

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Cristina Ramona Cudalbu

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences

Rolf Gruetter, Lijing Xin, Hanne Frenkel, Nathalie Just

To date, only a couple of functional MR spectroscopy (fMRS) studies were conducted in rats. Due to the low temporal resolution of 1H-MRS techniques, prolonged stimulation paradigms are necessary for investigating the metabolic outcome in the rat brain duri ...

Elsevier2013

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte

Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way. Beside the measurement of the total ...

2013

MAGNETIC RESONANCE AND BIOLUMINESCENCE IMAGING MONITOR QUANTITATIVE DIFFERENCES IN PANCREATIC ISLETS AND THEIR REGENERATION AFTER BETA CELL LOSS

Rolf Gruetter, Hongxia Lei

FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA2013

Brain metabolism in rat model of human glioma initiating cells

Arnaud Comment, Rolf Gruetter, Cristina Ramona Cudalbu, Mor-Miri Mishkovsky

2013

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

Wiley-Blackwell2013

Single spin-echo T 2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin, Cristina Ramona Cudalbu

OBJECT: To determine the single spin-echo T 2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T. MATERIALS AND METHODS: Measurements were performed on ...

Springer Verlag2013

Direct mapping of 19F in 19FDG-6P in brain tissue at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate

Low energy x-ray fluorescence (LEXRF) detection was optimized for imaging cerebral glucose metabolism by mapping the fluorine LEXRF signal of 19 F in 19 FDG, trapped as intracellular 19 F-deoxyglucose-6-phosphate ( 19 FDG-6P) at 1μm spatial resolution from ...

2013

Acetylcarnitine turnover in rat skeletal muscle measured in vivo using localized 13C NMR at 14.1 T

Arnaud Comment, Rolf Gruetter, João Miguel das Neves Duarte, Josefina Adriana Maria Bastiaansen

2013

Improved off-resonance phase behaviour using a phase-inverted adiabatic half passage pulse for 13C NMR spectroscopy in humans at 7T

Eulalia Serés Roig, Rolf Gruetter, Lijing Xin, Daniel Gallichan

2013

Metabolism of [1,6-C-13]glucose in glutamatergic and GABAergic compartments in vivo in the rat brain

Rolf Gruetter, João Miguel das Neves Duarte

Wiley-Blackwell2013

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

Rolf Gruetter, Benoît Schaller, Lijing Xin, Cristina Ramona Cudalbu

The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signa ...

Wiley-Blackwell2013

Hepatic glucose sensing is required to preserve β cell glucose competence

Bernard Lanz, Rolf Gruetter, Carole Poitry-Yamate, Frédéric Schütz

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine

Arnaud Comment, Rolf Gruetter, João Miguel das Neves Duarte, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen

BACKGROUND: Acetate metabolism in skeletal muscle is regulated by acetylCoA synthetase (ACS). The main function of ACS is to provide cells with acetylCoA, a key molecule for numerous metabolic pathways including fatty acid and cholesterol synthesis and the ...

Elsevier Science Bv2013

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

Nicolas Kunz, Rolf Gruetter, Yohan Van de Looij

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

Wiley-Blackwell2013

Hyperpolarized [1-13C]lactate metabolism in rat skeletal muscle in vivo

Arnaud Comment, Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Yuhei Takado, Hikari Ananda Infinity Yoshihara

2013

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