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Rolf Gruetter

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Publications associées (418)

Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes

Bernard Lanz, Rolf Gruetter, Marta Lai

The combination of dynamic (13)C MRS data under infusion of (13)C-labeled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific activit ...

Elsevier2017

N-Acetyl-Cysteine In A Doubleblind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment In Early Psychosis

Thierry Buclin, Rolf Gruetter, Lijing Xin, Kim Do

Oxford Univ Press2017

Metabolite concentration changes during increase of the BOLD signal in the human visual cortex: a functional magnetic resonance spectroscopy study at 7T

Rolf Gruetter, Lijing Xin, Wietske Van der Zwaag, Yohan Boillat

Sage Publications Inc2017

Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

In the brain, glycogen is a source of glucose not only in emergency situations but also during normal brain activity. Altered brain glycogen metabolism is associated with energetic dysregulation in pathological conditions, such as diabetes or epilepsy. Bot ...

Elsevier2017

Prospective head motion correction using FID-guided on-demand image navigators

Reto Meuli, Rolf Gruetter, Bénédicte Marie Maréchal, Guillaume Bonnier, Gunnar Krüger, Tobias Kober, Tom Hilbert, Maryna Volodimirivna Waszak, Pavel Falkovskiy

PURPOSE: We suggest a motion correction concept that employs free-induction-decay (FID) navigator signals to continuously monitor motion and to guide the acquisition of image navigators for prospective motion correction following motion detection. METHODS: ...

Wiley-Blackwell2017

Rates oxidative metabolism in astrocytes and neurons are coupled to the glutamate-glutamine cycle in the tree shrew visual cortex

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay, Anne Catherine Clerc

Wiley2017

Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery

Rolf Gruetter, João Miguel das Neves Duarte

Patients with diabetes display a progressive decay in the physiological counter-regulatory response to hypoglycemia, resulting in hypoglycemia unawareness. The mechanism through which the brain adapts to hypoglycemia may involve brain glycogen. We tested t ...

Springer Verlag2017

Diffusion-weighted MRS of acetate in the rat brain

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, Masoumeh Dehghani Moghadam, Hikari Ananda Infinity Yoshihara

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Wiley-Blackwell2017

Cannabis use decreases prefrontal glutamate levels in early psychosis

Rolf Gruetter, Lijing Xin, Kim Do

Elsevier France-Editions Scientifiques Medicales Elsevier2017

Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress

Maria del Carmen Sandi Perez, Rolf Gruetter, Hongxia Lei, Antoine Timothée Cherix, Thomas Didier Larrieu, João Pedro de Matos Rodrigues, Maria Aranzazu Duque Moreno

Extensive data highlight the existence of major differences in individuals’ susceptibility to stress [1; 2; 3 ; 4]. While genetic factors [5 ; 6] and exposure to early life stress [7 ; 8] are key components for such neurobehavioral diversity, intriguing ob ...

2017

Glucose and glycogen metabolism in the brain of insulin resistant Goto-Kakizaki rats

Rolf Gruetter, João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares

Sage Publications Inc2017

Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R1, R⁎2 and susceptibility

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Diana Khabipova

In this manuscript, the use of quantitative imaging at ultra-high field is evaluated as a mean to study cyto and myelo-architecture of the cortex. The quantitative contrasts used are the longitudinal relaxation rate (R1), apparent transverse relaxation rat ...

Elsevier2017

N-acetyl-cysteine in a double-blind randomized placebo-controlled trial: Towards biomarker guided treatment in early psychosis

Rolf Gruetter, Lijing Xin, Kim Do

Elsevier France-Editions Scientifiques Medicales Elsevier2017

Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Many tissues exhibit metabolic compartmentation. In the brain, while there is no doubt on the importance of functional compartmentation between neurons and glial cells, there is still debate on the specific regulation of pathways of energy metabolism at di ...

Nature Publishing Group2016

Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner

Rolf Gruetter

PURPOSE: Modification of a clinical MRI scanner to enable simultaneous or rapid interleaved acquisition of signals from two different nuclei. METHODS: A device was developed to modify the local oscillator signal fed to the receive channel(s) of an MRI cons ...

Wiley-Blackwell2016

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Arnaud Comment, Rolf Gruetter, Ruud van Heeswijk, Riccardo Balzan, Mor-Miri Mishkovsky

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...

Wiley-Blackwell2016

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Rolf Gruetter, Benoît Schaller, Lijing Xin, Huanxiang Lu, Kim Do

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Oxford University Press2016

3D T 2-weighted imaging at 7T using dynamic kT-points on single-transmit MRI systems

Rolf Gruetter, Florent Eggenschwiler, José Pedro Rebelo Ferreira Marques, Kieran O'Brien, Daniel Gallichan

OBJECTIVES: For turbo spin echo (TSE) sequences to be useful at ultra-high field, they should ideally employ an RF pulse train compensated for the B 1 + inhomogeneity. Previously, it was shown that a single kT-point pulse designed in the small tip-angle re ...

Springer Verlag2016

Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Masoumeh Dehghani Moghadam

Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Sage Publications Ltd2016

Retrospective correction of involuntary microscopic head movement using highly accelerated fat image navigators (3D FatNavs) at 7T

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Daniel Gallichan

PURPOSE: The goal of the present study was to use a three-dimensional (3D) gradient echo volume in combination with a fat-selective excitation as a 3D motion navigator (3D FatNav) for retrospective correction of microscopic head motion during high-resoluti ...

Wiley-Blackwell2016

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