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Rolf Gruetter

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Publications associées (418)

Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

Rolf Gruetter, Benoît Schaller, Lijing Xin, Huanxiang Lu

Proton T(1) relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T(1) values of CH(3) and CH(2) group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in o ...

Wiley-Blackwell2013

SA2RAGE: A new sequence for fast B(1) (+) -mapping

Rolf Gruetter, Florent Eggenschwiler, Tobias Kober, José Pedro Rebelo Ferreira Marques

At high magnetic field strengths (≥3T), the radiofrequency wavelength used in MRI is of the same order of magnitude of (or smaller than) the typical sample size, making transmit magnetic field (B 1+) inhomogeneities more prominent. Methods such as radiofre ...

Wiley2012

A two-compartment mathematical model of neuroglial metabolism using [1-C-11] acetate

Bernard Lanz, Rolf Gruetter

The purpose of this study was to develop a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-C-11] acetate radiotracer experiments, using an approach previously applied in C-13 magnetic resonance spectroscopy (MRS), ...

Nature Publishing Group2012

Lactoferrine supplementation following Hypoxia-Ischemia in the immature rat brain: macro-, micro-structural and metabolic assessment of the neuroprotective effect using multimodal MR

Rolf Gruetter, Yohan Van de Looij

2012

Handling macromolecule signals in the quantification of the neurochemical profile

Rolf Gruetter, Cristina Ramona Cudalbu

In vivo localized proton magnetic resonance spectroscopy (1H MRS) became a powerful and unique technique to non-invasively investigate brain metabolism of rodents and humans. The main goal of 1H MRS is the reliable quantification of concentrations of metab ...

Ios Press2012

Localized in vivo hyperpolarization transfer sequences

Arnaud Comment, Rolf Gruetter, Mor-Miri Mishkovsky, Tian Cheng

In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13) C(2) ] and sodium [1-(13) C] acetate. The method p ...

Wiley-Blackwell2012

In vivo enzymatic assay of carnitine acetyl transferase and acetylCoA synthetase using hyperpolarized acetate

Arnaud Comment, Rolf Gruetter, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen

2012

The neurochemical profile quantified by in vivo(1)H NMR spectroscopy

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases wh ...

2012

A comparison of high-pass birdcage coils for small animal imaging at 9.4 and 14T

Arnaud Comment, Rolf Gruetter, Hongxia Lei, Tian Cheng, Jennifer Jung

2012

N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knock ...

2012

In vivo real time cardiac metabolism using hyperpolarized acetate

Arnaud Comment, Rolf Gruetter, Tian Cheng, Josefina Adriana Maria Bastiaansen

2012

MP2RAGE multiple sclerosis magnetic resonance imaging at 3 T

Reto Meuli, Rolf Gruetter, Delphine Ribes Lemay, Gunnar Krüger, Tobias Kober, Cristina Granziera

Objectives: Lesion detection and characterization in multiple sclerosis (MS) are an essential part of its clinical diagnosis and an important research field. In this pilot study, we applied the recently introduced two inversion-contrast magnetization-prepa ...

2012

The hand representation in the human cerebellum overlaps with the digit representations

Roberto Martuzzi, Rolf Gruetter, Olaf Blanke, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques, Remy Kusters

2012

Intra and cross-modal negative BOLD response to contrast-varying visual stimuli

Rolf Gruetter, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Patricia Figueiredo

The BOLD contrast is widely used to study brain function. Under externally-applied stimuli, positive BOLD responses (PBR) are generally attributed to local increases in brain activity. Negative BOLD responses (NBR) are also frequently observed, but their u ...

2012

The importance of priors for l2 regularization and total variation methods in quantitative susceptibility mapping

Rolf Gruetter, Yves Wiaux, José Pedro Rebelo Ferreira Marques, Gilles Puy, Diana Khabipova

Phase imaging has been demonstrated to offer a good contrast between and within brain tissues at 7T[1] with iron and myelin concentration being amongst the main modulators of the observed contrast due to their para- and dia-magnetic properties.Phase imagin ...

2012

A high-power RF switch for arterial spin labelling with a separate tagging coil

Rolf Gruetter, Hongxia Lei

International Society for Magnetic Resonance in Medicine2012

In vivo Structural Imaging of the Cerebellum, the Contribution of Ultra-High Fields

Rolf Gruetter, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques

This review covers some of the contributions to date from cerebellar imaging studies performed at ultra-high magnetic fields. A short overview of the general advantages and drawbacks of the use of such high field systems for imaging is given. One of the bi ...

Springer-Verlag2012

High‐field diffusion tensor imaging characterization of cerebral white matter injury in LPS exposed fetal sheep

Rolf Gruetter, Yohan Van de Looij

2012

Improved lipid profiling of the mouse liver by 1H-NMR spectroscopy at 14.1T in vivo

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Purpose/Introduction: Whole-body metabolic deregulation features changes in hepatic lipid dynamics. In vivo 1H-MRS allows to noninvasively assess hepatic lipid content (HLC) and composition both in humans [1] and rodents [2]. Transgenic mice provide insigh ...

Springer2012

Hyperpolarized 6Li as probe for hemoglobin oxygenation level

Arnaud Comment, Rolf Gruetter, Ruud van Heeswijk, Riccardo Balzan, Mor-Miri Mishkovsky

2012

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