The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the ...

Ios Press2012

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Arnaud Comment, Rolf Gruetter, Mor-Miri Mishkovsky

The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observati ...

Nature Publishing Group2012

Spread spectrum magnetic resonance imaging

Jean-Philippe Thiran, Pierre Vandergheynst, Dimitri Nestor Alice Van De Ville, Rolf Gruetter, Yves Wiaux, José Pedro Rebelo Ferreira Marques, Gilles Puy

We propose a novel compressed sensing technique to accelerate the magnetic resonance imaging (MRI) acquisition process. The method, coined spread spectrum MRI or simply s2MRI, consists of pre-modulating the signal of interest by a linear chirp before rando ...

Institute of Electrical and Electronics Engineers2012

Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain barrier

Rolf Gruetter, João Miguel das Neves Duarte

Determination of brain glucose transport kinetics in vivo at steady-state typically does not allow distinguishing apparent maximum transport rate (Tmax) from cerebral consumption rate. Using a four-state conformational model of glucose transport, we show t ...

Wiley-Blackwell2012

A comparison of in vivo (13) C MR brain glycogen quantification at 9.4 and 14.1 T

Yves Pilloud, Rolf Gruetter, Ruud van Heeswijk

The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized (13) C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio inc ...

Wiley2012

PACEUP-3DEPI: A highly Accelerated 3D-EPI Sequence for fMRI at 7T

Rolf Gruetter, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques, Mayur Narsude

2012

Temporal SNR characteristics in segmented 3D-EPI at 7T

Rolf Gruetter, Wietske Van der Zwaag, Gunnar Krüger, Tobias Kober, José Pedro Rebelo Ferreira Marques

Three-dimensional segmented echo planar imaging (3D-EPI) is a promising approach for high-resolution functional magnetic resonance imaging, as it provides an increased signal-to-noise ratio (SNR) at similar temporal resolution to traditional multislice 2D- ...

Wiley-Blackwell2012

Shared-conductor versus overlapped-loop quadrature surface coils: which performs better in human brain at 7T?

Rolf Gruetter

2012

Signal enhancement of Glycogen by 13C NMR spectroscopy using broadband 1H decoupling and NOE at 7T

Eulalia Serés Roig, Rolf Gruetter, Lijing Xin

2012

Prospective and retrospective motion correction in diffusion magnetic resonance imaging of the human brain

Rolf Gruetter, Gunnar Krüger, Tobias Kober

Diffusion-weighting in magnetic resonance imaging (MRI) increases the sensitivity to molecular Brownian motion, providing insight in the micro-environment of the underlying tissue types and structures. At the same time, the diffusion weighting renders the ...

Elsevier2012

In vivo assessment of myelination by phase imaging at high magnetic field

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Rajika Maddage

The present study evaluated the potential of using the phase of T-2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests ...

Elsevier2012

Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy

Nicolas Kunz, Rolf Gruetter, Yohan Van de Looij, Cristina Ramona Cudalbu

Elsevier2012

Metabolism of [1,6-C-13] glucose in glutamatergic and GABAergic compartments in vivo in the rat brain

Rolf Gruetter, João Miguel das Neves Duarte

Wiley-Blackwell2012

The influence of frontal glutathione levels on white matter connectivity in healthy and early psychosis subjects: a preliminary study

Jean-Philippe Thiran, Patric Hagmann, Rolf Gruetter, Lijing Xin, Alessandra Griffa, Kim Do

2012

Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

Yves Pilloud, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

Brain glutamine synthetase (GS) is an integral part of the glutamate-glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites ...

Nature Publishing Group2012

Brain metabolism in glutamatergic and GABAergic compartments detected by in vivo 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

2012

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