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Aleksandra Radenovic

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Publications associées (153)

Adaptive optics enables multimode 3D super-resolution microscopy via remote focusing

Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Kristin Stefanie Grussmayer, Sanjin Marion, Vytautas Navikas

A variety of modern super-resolution micro-scopy methods provide researchers with previouslyinconceivable biological sample imaging opportunities ata molecular resolution. All of these techniques excel atimaging samples that are close to the coverslip, how ...

2021

Pressure-Induced Enlargement and Ionic Current Rectification in Symmetric Nanopores

Aleksandra Radenovic, Sebastian James Davis, Michal Daniel Macha, Sanjin Marion, Andrey Chernev

Nanopores in solid state membranes are a tool able to probe nanofluidic phenomena or can act as a single molecular sensor. They also have diverse applications in filtration, desalination, or osmotic power generation. Many of these applications involve chem ...

2020

High-Throughput Nanocapillary Filling Enabled by Microwave Radiation for Scanning Ion Conductance Microscopy Imaging

Aleksandra Radenovic, Georg Fantner, Sebastian James Davis, Samuel Mendes Leitão, Sanjin Marion, Vytautas Navikas

Solid-state nanopores provide a highly sensitive tool for single-molecule sensing and probing nanofluidic effects in solutions. Glass nanopipettes are a cheap and robust type of solid-state nanopore produced from pulling glass capillaries with opening orif ...

2020

Direct observation of water-mediated single-proton transport between hBN surface defects

Aleksandra Radenovic, Benoît Grosjean, Jean Camille Benjamin Comtet, Evgenii Glushkov, Ahmet Avsar

Super-resolution microscopy of defects in a two-dimensional material unveils the transport of single proton charges at solid/water interfaces. Aqueous proton transport at interfaces is ubiquitous and crucial for a number of fields, ranging from cellular tr ...

2020

Recent Advances and Prospects in the Research of Nascent Adhesions

Aleksandra Radenovic, Ana-Suncana Smith

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins ...

FRONTIERS MEDIA SA2020

Wafer-Scale Fabrication of Nanopore Devices for Single-Molecule DNA Biosensing using MoS2

Andras Kis, Aleksandra Radenovic, Michael Graf, Martina Lihter, Jochem Deen, Michal Daniel Macha, Mukeshchand Thakur, Andrey Chernev, Mukesh Kumar Tripathi

Atomically thin (2D) nanoporous membranes are an excellent platform for a broad scope of academic research. Their thickness and intrinsic ion selectivity (demonstrated for example in molybdenum disulfide-MoS2) make them particularly attractive for single-m ...

2020

Self-Blinking Dyes Unlock High-Order and Multiplane Super-Resolution Optical Fluctuation Imaging

Theo Lasser, Aleksandra Radenovic, Tomas Lukes, Kristin Stefanie Grussmayer

Most diffraction-unlimited super-resolution imaging critically depends on the switching of fluorophores between at least two states, often induced using intense laser light and specialized buffers or UV radiation. Recently, so-called self-blinking dyes tha ...

AMER CHEMICAL SOC2020

Nanocapillary confinement of imidazolium based ionic liquids

Aleksandra Radenovic, Sebastian James Davis, Sanjin Marion, Zeng-Qiang Wu

Room temperature ionic liquids are salts which are molten at or around room temperature without any added solvent or solution. In bulk they exhibit glass like dependence of conductivity with temperature as well as coupling of structural and transport prope ...

2020

Benchmarking of single imaging datasets

Aleksandra Radenovic, Adrien Charles-François Raymond Descloux

A method of estimating a value (311-313) indicative of a signal component of an input imaging dataset (190) includes determining a normalized Fourier-domain representation of the input imaging dataset (190); and for each one of multiple low-pass filters (3 ...

2020

Logic-in-memory based on an atomically thin semiconductor

Andras Kis, Aleksandra Radenovic, Yanfei Zhao, Ahmet Avsar, Zhenyu Wang, Guilherme Migliato Marega, Mukesh Kumar Tripathi

The growing importance of applications based on machine learning is driving the need to develop dedicated, energy-efficient electronic hardware. Compared with von Neumann architectures, which have separate processing and storage units, brain-inspired in-me ...

2020

Spectral cross-cumulants for multicolor super-resolved SOFI imaging

Marcel Leutenegger, Theo Lasser, Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Tomas Lukes, Kristin Stefanie Grussmayer

Super-resolution opticalfluctuation imaging provides a resolution beyond the diffraction limitby analysing stochasticfluorescencefluctuations with higher-order statistics. Usingnthorderspatio-temporal cross-cumulants the spatial resolution and the sampling ...

Nature Research2020

Towards artificial mechanosensing

Aleksandra Radenovic, Sanjin Marion

Carbon nanotubes with single-digit diameter embedded in a solid artificial membrane show pressure-sensitive ionic conductance that is similar to the mechanically activated currents of biological ion channels. ...

NATURE PUBLISHING GROUP2020

Aerolysin nanopores decode digital information stored in tailored macromolecular analytes

Aleksandra Radenovic, Matteo Dal Peraro, Lucien Fabrice Krapp, Nuria Cirauqui Diaz, Chan Cao

Digital data storage is a growing need for our society and finding alternative solutions than those based on silicon or magnetic tapes is a challenge in the era of “big data.” The recent development of polymers that can store information at the molecular l ...

2020

High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism

Theo Lasser, Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Tomas Lukes, Vytautas Navikas

Super-resolution structured illumination microscopy (SR-SIM) can be conducted at video-rate acquisition speeds when combined with high-speed spatial light modulators and sCMOS cameras, rendering it particularly suitable for live-cell imaging. If, however, ...

2020

Prospects of Observing Ionic Coulomb Blockade in Artificial Ion Confinements

Aleksandra Radenovic, Sanjin Marion, Andrey Chernev

Nanofluidics encompasses a wide range of advanced approaches to study charge and mass transport at the nanoscale. Modern technologies allow us to develop and improve artificial nanofluidic platforms that confine ions in a way similar to single-ion channels ...

MDPI2020

Polymer Coatings to Minimize Protein Adsorption in Solid-State Nanopores

Michael Mayer, Aleksandra Radenovic, Sebastian James Davis, Sanjin Marion

Nanopore-based resistive-pulse recordings represent a promising approach for single-molecule biophysics with applications ranging from rapid DNA and RNA sequencing to "fingerprinting" proteins. Based on advances in fabrication methods, solid-state nanopore ...

WILEY-V C H VERLAG GMBH2020

Microscopic Detection Analysis of Single Molecules in MoS2 Membrane Nanopores

Aleksandra Radenovic, Michael Graf

A systematic microscopic analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The variations of the transverse electronic current along the two-dimensional (2 ...

2020

Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions

Aleksandra Radenovic, Sylvie Roke, Orly Bagunu Tarun, Maksim Eremchev

Ion channels are responsible for numerous physiological functions ranging from transport to chemical and electrical signaling. Although static ion channel structure has been studied following a structural biology approach, spatiotemporal investigation of t ...

American Chemical Society (ACS)2019

Identifying microbial species by single-molecule DNA optical mapping and resampling statistics

Theo Lasser, Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Arno Pino Bouwens, Tomas Lukes, Jochem Deen, Kristin Stefanie Grussmayer

Single-molecule DNA mapping has the potential to serve as a powerful complement to high-throughput sequencing in metagenomic analysis. Offering longer read lengths and forgoing the need for complex library preparation and amplification, mapping stands to p ...

2019

2D materials as an emerging platform for nanopore-based power generation

Aleksandra Radenovic, Michal Daniel Macha, Sanjin Marion

Osmotic power generation, the extraction of power from mixing salt solutions of different concentrations, can provide an efficient power source for both nanoscale and industrial-level applications. Power is generated using ion-selective channels or pores o ...

2019

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