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Aleksandra Radenovic

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Publications associées (152)

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Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation

Aleksandra Radenovic, Andras Kis, Ke Liu, Jiandong Feng

Atomically thin nanopore membranes are considered to be a promising approach to achieve single base resolution with the ultimate aim of rapid and cheap DNA sequencing. Molybdenum disulfide (MoS2) is newly emerging as a material complementary to graphene du ...

Amer Chemical Soc2014

Single florescent nanodiamond in a three dimensional ABEL trap

Aleksandra Radenovic, Metin Kayci

Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteri ...

Nature Publishing Group2015

Aerolysin nanopores decode digital information stored in tailored macromolecular analytes

Aleksandra Radenovic, Matteo Dal Peraro, Chan Cao, Lucien Fabrice Krapp

Digital data storage is a growing need for our society and finding alternative solutions than those based on silicon or magnetic tapes is a challenge in the era of “big data.” The recent development of polymers that can store information at the molecular l ...

2020

Electrochemical Reaction in Single Layer MoS2: nanopores opened atom by atom

Aleksandra Radenovic, Andras Kis, Duncan Thomas Lindsay Alexander, Dumitru Dumcenco, Martina Lihter, Ke Liu, Michael Graf, Roman Bulushev, Jiandong Feng, Daria Krasnozhon

Ultrathin nanopore membranes based on 2D materials have demonstrated ultimate resolution toward DNA sequencing. Among them, molybdenum disulfide (MoS2) shows long-term stability as well as superior sensitivity enabling high throughput performance. The trad ...

American Chemical Society (ACS)2015

Geometrical Effect in 2D Nanopores

Andras Kis, Aleksandra Radenovic, Duncan Thomas Lindsay Alexander, Vasiliki Tileli, Dumitru Dumcenco, Martina Lihter, Ke Liu, Davide Deiana

A long-standing problem in the application of solid-state nanopores is the lack of the precise control over the geometry of artificially formed pores compared to the well-defined geometry in their biological counterpart, that is, protein nanopores. To date ...

American Chemical Society (ACS)2017

Spatially multiplexed single-molecule translocations through a nanopore at controlled speeds

Gordanna Pistoletti Blanchet, Aleksandra Radenovic, Georg Fantner, Sanjin Marion, Vytautas Navikas, Samuel Mendes Leitão, Barney Frederick Drake, Simon Finn Mayer, Helena Miljkovic

In current nanopore-based label-free single-molecule sensing technologies, stochastic processes influence the selection of translocating molecule, translocation rate and translocation velocity. As a result, single-molecule translocations are challenging to ...

2023

High throughput second harmonic imaging for label-free biological applications

Pierre Magistretti, Pierre Marquet, Aleksandra Radenovic, Sylvie Roke, Pascal Jourdain, Orly Bagunu Tarun, Carlos Alberto Macias Romero, Vitalijs Zubkovs, Marie Eve Pascale Didier

Second harmonic generation (SHG) is inherently sensitive to the absence of spatial centrosymmetry, which can render it intrinsically sensitive to interfacial processes, chemical changes and electrochemical responses. Here, we seek to improve the imaging th ...

Optical Society of America2014

Spatiotemporal Imaging of Water in Operating Voltage-Gated Ion Channels Reveals the Slow Motion of Interfacial Ions

Sylvie Roke, Aleksandra Radenovic, Orly Bagunu Tarun, Maksim Eremchev

Ion channels are responsible for numerous physiological functions ranging from transport to chemical and electrical signaling. Although static ion channel structure has been studied following a structural biology approach, spatiotemporal investigation of t ...

American Chemical Society (ACS)2019

Direct observation of water-mediated single-proton transport between hBN surface defects

Aleksandra Radenovic, Ahmet Avsar, Evgenii Glushkov, Jean Camille Benjamin Comtet

Super-resolution microscopy of defects in a two-dimensional material unveils the transport of single proton charges at solid/water interfaces. Aqueous proton transport at interfaces is ubiquitous and crucial for a number of fields, ranging from cellular tr ...

2020

Progress in quantitative single-molecule localization microscopy

Aleksandra Radenovic, Marco Scarselli, Hendrik Georges Deschout, Arun Shivanandan, Paolo Annibale

With the advent of single-molecule localization microscopy (SMLM) techniques, intracellular proteins can be imaged at unprecedented resolution with high specificity and contrast. These techniques can lead to a better understanding of cell functioning, as t ...

Springer2014

Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy

Aleksandra Radenovic, Georg Fantner, Vytautas Navikas, Adrien Charles-François Raymond Descloux, Samuel Mendes Leitão, Kristin Stefanie Grussmayer, Barney Frederick Drake

High-resolution live-cell imaging is necessary to study complex biological phenomena. Modern fluorescence microscopy methods are increasingly combined with complementary, label-free techniques to put the fluorescence information into the cellular context. ...

Nature Research2021

Nanopore Integrated Nanogaps for DNA Detection

László Forró, Aleksandra Radenovic, Arnaud Magrez, Axel Fanget, Floriano Traversi

A high-throughput fabrication of sub-10 nm nanogap electrodes combined with solid-state nanopores is described. These devices should allow concomitant tunneling and ionic current detection of translocating DNA molecules. We report the optimal fabrication p ...

American Chemical Society2014

Adaptive optics enables multimode 3D super-resolution microscopy via remote focusing

Aleksandra Radenovic, Sanjin Marion, Vytautas Navikas, Adrien Charles-François Raymond Descloux, Kristin Stefanie Grussmayer

A variety of modern super-resolution micro-scopy methods provide researchers with previouslyinconceivable biological sample imaging opportunities ata molecular resolution. All of these techniques excel atimaging samples that are close to the coverslip, how ...

2021

Facile Production of Hexagonal Boron Nitride Nanoparticles by Cryogenic Exfoliation

Aleksandra Radenovic, Evgenii Glushkov, Vytautas Navikas, Andrey Chernev, Jean Camille Benjamin Comtet

Fluorescent nanoparticles with optically robust luminescence are imperative to applications in imaging and labeling. Here we demonstrate that hexagonal boron nitride (hBN) nanoparticles can be reliably produced using a scalable cryogenic exfoliation techni ...

AMER CHEMICAL SOC2019

Identifying microbial species by single-molecule DNA optical mapping and resampling statistics

Theo Lasser, Aleksandra Radenovic, Arno Pino Bouwens, Tomas Lukes, Adrien Charles-François Raymond Descloux, Kristin Stefanie Grussmayer, Jochem Deen

Single-molecule DNA mapping has the potential to serve as a powerful complement to high-throughput sequencing in metagenomic analysis. Offering longer read lengths and forgoing the need for complex library preparation and amplification, mapping stands to p ...

2019

2D MoS2 nanopores: ionic current blockade height for clustering DNA events

Aleksandra Radenovic, Ke Liu

2D nanopores can be used to electrophoretically drive DNA molecules, which can in turn be identified through measurable electronic current blockades. In this work, we use experimental data from molybdenum disulfide nanopores threading DNA nucleotides and p ...

2019

Electrochemical Functionalization of Selectively Addressed MoS2 Nanoribbons for Sensor Device Fabrication

Aleksandra Radenovic, Vasiliki Tileli, Martina Lihter, Michal Daniel Macha, Tzu-Hsien Shen, Michael Graf, Yanfei Zhao, Miao Zhang

Tailoring the surface properties of 2D materials, such as transition metal dichalcogenides (TMDCs), at the nanoscale is becoming essential in the fabrication of various 2D material-based nanoelectronic devices. Due to the chemical inertness of their basal ...

AMER CHEMICAL SOC2021

Label-Free Imaging of DNA Interactions with 2D Materials

Aleksandra Radenovic, Suliana Manley, Nathan Cyprien Arsène Ronceray, Wayne Yang Wen Wei, Jenny Sülzle, Eveline Simone Mayner, Yuta Shimoda

Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their properties can be engineered to tune interactions between the surface and biomolecules. Yet, not many methods can measure these interactions in a liquid environme ...

2024

Statistical distortion of supervised learning predictions in optical microscopy induced by image compression

Aleksandra Radenovic, David Nguyen, Arielle Louise Planchette

The growth of data throughput in optical microscopy has triggered the extensive use of supervised learning (SL) models on compressed datasets for automated analysis. Investigating the effects of image compression on SL predictions is therefore pivotal to a ...

Nature Portfolio2022

Micro-fabrication process for small transport devices of layered manganite

Henrik Moodysson Rønnow, Aleksandra Radenovic, Andras Kis, Arash Alahgholipour Omrani

Devices have been fabricated based on the bilayer manganite La1.4Sr1.6Mn2O7, which in the bulk state orders magnetically below 90 K, at which point both in-plane and c-axis bulk resistivity decrease by 2-3 orders of magnitude. We provide an optimized proce ...

American Institute of Physics2012