Publications de Harm-Anton Klok

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A new class of water-soluble, amphiphilic star block copolymers with a large number of arms was prepared by sequential atom transfer radical polymerization (ATRP) of n-butyl methacrylate (BMA) and poly-(ethylene glycol) methyl ether methacrylate (PEGMA). A ...

Inhibition of P-glycoprotein (P-gp) transporter is an attractive approach for the reversion of cancer-associated multidrug resistance (MDR). Poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA)-based carriers that are able to release the anticancer drug doxoru ...

Controlled radical polymerization techniques such as RAFT allow fine control over polymer molecular weight and architecture. These techniques, however, do not eliminate compositional drifts in copolymerizations, which are the consequence of differences in ...

Oligomers with well-defined chain lengths are of interest as foldamers, are important as model compounds for high-molecular-weight polymers and find application in electrooptic and sensory devices. This account presents an overview of the strategies that a ...

With a span as long as the history of polymer science itself, post-polymerization modification represents a versatile platform for the preparation of diversely functionalized polymers from a single precursor. Starting with the initial efforts by Staudinger ...

The use of polymers has revolutionized the field of drug delivery in the past two decades. Properties such as polymer size, charge, hydrophilicity, or branching have all been shown to play an important role in the cellular internalization of polymeric syst ...

Polymer brushes are densely grafted, chain end-tethered assemblies of polymers that can be produced via surface-initiated polymerization. Typically, this is accomplished using initiators or chain transfer agents that are covalently attached to the substrat ...

Tissue engineering technologies are new and promising techniques in fat tissue reconstruction. However, to assess their efficacy before any clinical application, in vivo experiments are mandatory. This study assesses whether microcomputed tomography (CT) s ...

Gold nanoparticles modified with a two (or multi-) component polymer brush coating are an exciting class of nanomaterials. The presentation of two (or more) different polymer components can lead to truly multifaceted nanoparticles that can incorporate mult ...

Benzo-15-crown-5 functionalized polymer brushes prepared via surface-initiated atom transfer radical polymerization are used as the active layer in a potassium-selective quartz crystal microbalance sensor. The polymer brushes allow the selective detection ...

Polypeptide brushes are attractive platforms to generate functional and responsive interfaces that are of potential interest due to their possible biodegradability, biocompatibility and tunable secondary structures. Surface-initiated ringopening polymeriza ...

This contribution reports on the synthesis of hyperbranched polylysines via thermal polymerization of L-lysine hydrochloride. Polymerization of L-lysine hydrochloride in the presence of one equivalent KOH at 150°C resulted in polymers with a number-average ...

Mechanical stimuli are ubiquitous in the human body. In contrast to biochemical stimuli such as pH, redox, hypoxia or enzymes as well as exogenous stimuli such as magnetic fields, temperature or ultrasound, endogenous biomechanical stimuli have only receiv ...

A new method for generating a surface density gradient of polymer chains is presented. A substrate-independent polymer deposition technique was used to coat materials with a chemical gradient based on plasma copolymerization of 1,7-octadiene and allylamine ...

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also ...

Harm-Anton Klok

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Water-soluble, unimolecular containers based on amphiphilic multiarm star block copolymers

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

Avoiding compositional drift during the RAFT copolymerization of N-(2-hydroxypropyl)methacrylamide and N-acryloxysuccinimide: towards uniform platforms for post-polymerization modification

Synthesis of uniform, non-natural oligomers

Standing on the shoulders of hermann staudinger: Post-polymerization modification from past to present

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

Polymers at Interfaces

Secondary structure formation and LCST behaviour of short, elastin-like peptides

Supramolecular Polymer Brushes Grown by Surface-Initiated Atom Transfer Radical Polymerization from Cucurbit[7]uril-based Non-Covalent Initiators

Microcomputed Tomography Technique for In Vivo Three-Dimensional Fat Tissue Volume Evaluation After Polymer Injection

Multifaceted polymer coated, gold nanoparticles

Orthogonally Functionalizable Redox-Responsive Polymer Brushes: Catch and Release Platform for Proteins and Cells

A Potassium-Selective Quartz Crystal Microbalance Sensor Based on Crown-Ether Functionalized Polymer Brushes

Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications

Polypeptide brushes grown via surface-initiated ring-opening polymerization of alpha-amino acid N-carboxyanhydrides

Polymers, Colloids, and Interfaces

The thermal polymerization of amino acids revisited; Synthesis and structural characterization of hyperbranched polymers from L-lysine

Mechanoresponsive Micro- and Nanoparticles

Polymer Brush Gradients Grafted from Plasma-Polymerized Surfaces

One-pot squaric acid diester mediated aqueous protein conjugation