Publications de Harm-Anton Klok

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Postpolymerization modification reactions are widely employed to prepare functional polymer brushes. Relatively little is known, however, about the distribution of functional groups in such postmodified brushes. Using neutron reflectometry and UV-vis spect ...

Self-diffusion NMR spectroscopy and relaxometry have been employed to study fragrance encapsulation in water-soluble, amphiphilic star block copolymers. Diffusion coefficients of four different fragrance molecules in the free form and in the presence of th ...

Small-angle neutron scattering and pulsed-gradient spin-echo NMR have been used to examine the solution conformation of a series of water soluble poly(N-(2-hydroxypropyl) methacrylamide) P(HPMA) co-polymer drug delivery vehicles incorporating a coiled-coil ...

Thin polymer films that are able to bind proteins are of great relevance for a wide variety of biosensor and biochip applications. Some of these applications require films that have high protein binding capacities while others call for surfaces that allow ...

An optical method is presented that allows the measurement of the triplet lifetime of a fluorescent molecule. This is a characteristic specific to each fluorophore. Based on differences in triplet lifetimes of two fluorescent species (autofluorescence vers ...

A series of 3 homologous surface-anchored initiators for atom transfer radical polymerization has been used to graft linear, Y- and Ψ-shaped poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(methyl methacrylate) (PMMA) brushes from silicon surfa ...

Polymer brushes grafted by surface-initiated atom transfer radical polymerization (SI-ATRP) from the surface of Ir-based microelectrode arrays are explored as a platform for the fabrication of sensory coatings for the voltammetric detection of Hg2+. The po ...

Poly(lactic acid) (PLA) represents one of the most widely used biodegradable polymers for food packaging applications. While this material provides many advantages, it is characterized by limited antioxidant and UV-barrier properties. Blending PLA with lig ...

Peptide/protein-synthetic polymer conjugates, which covalently combine one or more copies of a peptide sequence or protein with one or more synthetic polymer elements. offer unique possibilities to integrate the properties and functions of bio(macro)molecu ...

Peptide-synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of ?-amino acid N-carboxyanhydrides using appropriately end-functionalized synthetic polymers as the macroinitiator. This class of peptide-synthetic hybrid b ...

Cyclic peptide disulfides (CXC) are an important class of biomolecules. The conjugation of cyclic peptide disulfides to synthetic polymers, however, is often difficult due to the presence of the disulfide bond combined with other potentially reactive side ...

Swelling in polymer materials is a ubiquitous phenomenon. At a molecular level, swelling is dictated by solvent-polymer interactions, and has been thoroughly studied both theoretically and experimentally. Favorable solvent-polymer interactions result in th ...

Cells are promising as carriers that can enhance the delivery of nanomedicines. Cells that carry nanomedicinal cargo, either immobilized on the cell surface or internalized, can allow for highly specific delivery and can enable the transport of nanomedicin ...

Because of the unequal reactivity of the two amine groups of L-lysine hydrochloride, thermal polymerization of this asymmetrical AB2 monomer results in hyperbranched polymers, which contain ?2.5 times more N?-linked linear compared to N?-linked linear stru ...

This paper reports the synthesis and characterization of a novel class of dendronized polymers which are based on styrene functionalized dendritic L-lysine macromonomers. Free radical polymerization of zeroth and first generation macromonomers afforded den ...

Bacteria represent a class of living cells that are very attractive carriers for the transport and delivery of nano- and microsized particles. The use of cell-based carriers, such as for example bacteria, may allow to precisely direct nano- or microsized c ...

Surface-grafted polymer brushes are a very attractive class of boundary lubricants. This article presents an overview of the tribological properties of surface-attached synthetic polymers. After a brief review of some mechanistic considerations and a discu ...

Harm-Anton Klok

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Neutron Reflectivity Study on the Postpolymerization Modification of Poly(2-hydroxyethyl methacrylate) Brushes

NMR diffusion and relaxation studies of the encapsulation of fragrances by amphiphilic multiarm star block copolymers

Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers

Polymer brush interfaces for protein biosensing prepared by surface-initiated controlled radical polymerization

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

Trace element and isotope labels to study uptake and intracellular trafficking of polymer conjugates

Linear, Y- and Ψ-shaped poly(2-(dimethylamino)ethyl methacrylate) and poly(methyl methacrylate) brushes prepared by surface-initiated polymerization from a homologous series of ATRP initiators

Voltammetric Detection of Hg2+ Using Peptide-Functionalized Polymer Brushes

Uniformly Dispersed Poly(lactic acid)-Grafted Lignin Nanoparticles Enhance Antioxidant Activity and UV-Barrier Properties of Poly(lactic acid) Packaging Films

Peptide/Protein−Synthetic Polymer Conjugates: Quo vadis

Solid-state structure, organization and properties of peptide-synthetic hybrid block copolymers

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

Future Directions at the Frontier of Polymer Science and Biology

Swelling-Activated, Soft Mechanochemistry in Polymer Materials

Chemical Cell Surface Modification and Analysis of Nanoparticle-Modified Living Cells

Controlling polymer architecture in the thermal hyperbranched polymerization of L-lysine

L-lysine dendronized polystyrene

Chemical Approaches for the Preparation of Bacteria - Nano/Microparticle Hybrid Systems

Polymers at the Interface with Biology

Tribology of surface-grafted polymer brushes