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Harm-Anton Klok

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Related publications (195)

Polymer Brush Guided Formation of Thin Gold and Palladium/Gold Bimetallic Films

This manuscript reports a new strategy to guide the chemical solution deposition of thin, microstructured metal films. The proposed strategy is based on the use of poly(2-(methacryloyloxy)ethyl ammonium chloride) (PMETAC) brushes grown via surface-initiate ...

2011

Synthesis of Side-Chain Functional Polyesters via Baylis-Hillman Polymerization

Harm-Anton Klok, Sanhao Ji

Strategies that allow access to side-chain functional polyesters are valuable as they would enable to engineer the properties of these hydrolytically degradable materials. This contribution explores the feasibility of a novel approach toward side-chain fun ...

American Chemical Society2011

Arginine-Specific Modification of Proteins with Polyethylene Glycol

Harm-Anton Klok, Marc Gauthier

In this study, the residue-selective modification of proteins with polymers at arginine residues is reported. The difficulty in modifying arginine residues lies in the fact that they are less reactive than lysine residues. Consequently, typical chemo-selec ...

American Chemical Society2011

Polymer Coiled-Coil Conjugates: Potential for Development as a New Class of Therapeutic “Molecular Switch”

Harm-Anton Klok

Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and patho ...

American Chemical Society2011

Size-Dependent LCST Transitions of Polymer-Coated Gold Nanoparticles: Cooperative Aggregation and Surface Assembly

Harm-Anton Klok, Dusko Paripovic, Matthew Gibson

Nanoparticles working together. Thermoresponsive polymer-coated nanoparticles are shown to display size dependent, cooperative, lower critical solution temperature behavior. This is exploited to direct the assembly of appropriate nanoparticles onto complem ...

Wiley-Blackwell2010

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials

Harm-Anton Klok, Maarten Danial

The coiled coil is a superhelical protein structural motif that consists of two or more alpha-helical peptides that are wrapped around each other in superhelical fashion. Coiled coils are amongst the most ubiquitous folding motifs found in proteins and hav ...

Royal Society of Chemistry2010

A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes

Jeffrey Alan Hubbell, Harm-Anton Klok, Brian Pullin

This manuscript reports a facile strategy for the modification of polyethylene, a widely used biomaterial, with a thin non-biofouling coating that can act as a platform to introduce biochemical cues to control and direct, e.g., cell adhesion and proliferat ...

Wiley-Blackwell2010

Room Temperature, Aqueous Post-Polymerization Modification of Glycidyl Methacrylate-Containing Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

Raphaël Barbey, Harm-Anton Klok

This manuscript reports on the post-polymerization modification of poly(glycidyl methacrylate) (PGMA) and PGMA-co-poly(2-(diethylamino)ethyl methacrylate) (PGMA(x)-co-PDEAEMA(y)) (co)polymer brushes prepared via surface-initiated atom transfer radical poly ...

2010

Protein Microarrays Based on Polymer Brushes Prepared via Surface-Initiated Atom Transfer Radical Polymerization

Raphaël Barbey, Markus Ehrat, Harm-Anton Klok

Polymer brushes represent an interesting platform for the development of high-capacity protein binding surfaces. Whereas the protein binding properties of polymer brushes have been investigated before, this manuscript evaluates the feasibility of poly(glyc ...

American Chemical Society2010

Polymer Conjugates

Harm-Anton Klok

2010

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

Harm-Anton Klok

This article reports the design, synthesis and results of first in vitro model studies of a conceptually novel class of polymer therapeutics in which the cargo is attached to a polymer backbone via a noncovalent, biologically inspired coiled coil linker, w ...

American Chemical Society2010

Polymer–protein conjugates: an enzymatic activity perspective

Harm-Anton Klok, Marc Gauthier

Proteins have been modified with polymers in diverse manners over the past 30 years. However, while proteins have been used to prepare many functional constructs, they are sensitive biomolecules and their bioactivity can be either positively or negatively ...

2010

Synthesis of Functional Polydepsipeptides via Direct Ring-Opening Polymerization and Post-Polymerization Modification

Harm-Anton Klok, Nadja Franz

This contribution explores different strategies for the synthesis of side chain functional polydepsipeptides. First, the ring-opening polymerization of side chain functional morpholine-2,5-diones is revisited and the optimized reaction conditions used for ...

2010

A Potassium-Selective Quartz Crystal Microbalance Sensor Based on Crown-Ether Functionalized Polymer Brushes

Harm-Anton Klok, Nicolas Bertrand Schüwer

Benzo-15-crown-5 functionalized polymer brushes prepared via surface-initiated atom transfer radical polymerization are used as the active layer in a potassium-selective quartz crystal microbalance sensor. The polymer brushes allow the selective detection ...

Wiley-Blackwell2010

Copolymerization Behavior of N-(2-Hydroxypropyl)methacrylamide and methacrylated coiled-coil peptide derivative

Harm-Anton Klok

American Chemical Society2010

Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

Raphaël Barbey, Harm-Anton Klok, Matthew Gibson, Jian Wang

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anc ...

2009

Degradable Polymer Brushes Prepared via Surface-Initiated Controlled Radical Polymerization

Harm-Anton Klok, Nicolas Bertrand Schüwer, Carl Riachi

Hydrolytically degradable polymer brushes would represent an interesting platform for the development of functional coatings for various biomaterials applications In this manuscript, the surface- initiated atom transfer radical copolymerization of 5.6-benz ...

American Chemical Society2009

A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers

Harm-Anton Klok, Nadja Franz, Laure Menin

Hydrophilic/hydrophobic patterning is a well-established design strategy to guide secondary structure formation of both natural as well as non-natural oligomers and polymers. This contribution explores the feasibility of a new approach for the synthesis of ...

2009

Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules

Harm-Anton Klok, Markus Scholl, Zuzana Kadlecova

Aim: Treatment of sensorineural hearing loss could be advanced using novel drug carriers such as hyperbranched polylysine (HBPL) or lipid nanocapsules (LNCs). This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in ...

Future Medicine2009

A post-modification approach to peptide foldamers

Harm-Anton Klok, Nadja Franz, Laure Menin

Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide folda ...

Royal Society of Chemistry2009

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