Luc Reymond

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Publications associées (46)

Modified short interfering RNA

Luc Reymond, Evelyne Muller

The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), ...

2006

Molecular basis of RNA recognition by the human alternative splicing factor Fox-1

Luc Reymond

The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the soln. structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a ...

2006

Synthesis and evaluation of 2'-O-substituted oligoribonucleotide analogues with new properties

Luc Reymond

During a previous, exploratory project in our group, it was observed that duplexes formed by oligonucleotides modified with polar 2'-O-substituents were more tolerant towards the addition of 1,2-dimethoxyethane (DME) than RNA and DNA duplexes [1]. Inspired ...

EPFL2006

Short, synthetic and selectively 13C-labeled RNA sequences for the NMR structure determination of protein–RNA complexes

Philipp Wenter, Luc Reymond

We report an optimized synthesis of all canonical 2'-O-TOM protected ribonucleoside phosphoramidites and solid supports containing [13C5]-labeled ribose moieties, their sequence-specific introduction into very short RNA sequences and their use for the stru ...

Oxford University Press2006

Preparation of modified RNA sequences for biological research

Philipp Wenter, Sébastien Porcher, Damian Ackermann, Frédéric David Meylan, Luc Reymond, Evelyne Muller

Our group is working on the development of reliable access to biol. relevant, long, and modified RNA sequences. Here, we briefly present the chem. synthesis of such sequences with 2'-O-triisopropylsilyloxymethyl (= 2'-O-tom) protected ribonucleoside phosph ...

2005

Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation

Philipp Wenter, Luc Reymond

The polypyrimidine tract binding protein (PTB) is a 58-kDa RNA binding protein involved in multiple aspects of mRNA metab., including the repression of alternative exons. We have detd. the soln. structures of the four RNA binding domains (RBDs) of PTB, eac ...

American Association for the Advancement of Science2005

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