To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1a, a m ...

Oxford University Press2017

In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system

Philippe Renaud, Arnaud Bertsch, Philippe Colin, Bernard Schneider, Guillaume Cédric Yves Petitpierre, Aurélien Thomas

Direct collection of extracellular fluid (ECF) plays a central role in the monitoring of neurological disorders. Current approaches using microdialysis catheters are however drastically limited in term of temporal resolution. Here we show a functional in v ...

Nature Publishing Group2017

Bicistronic aav vector for rna interference in als

Bernard Schneider, Cylia Cloé Rochat, Julianne Bobela

The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of sai ...

2017

Validation of Scalable and Compliant AAV Production

Florian Maria Wurm, Nicole Déglon, Bernard Schneider, Gabriel Vachey, Daniel Roman Blessing

Cell Press2017

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

Patrick Aebischer, Bernard Schneider, Vanessa Laversenne, Aurélien Lathuilière, Marco Stampanoni

Passive immunization against toxic misfolded proteins could offer protection against neurodegenerative disease. LathuiliSre et al. report the development of a retrievable device to encapsulate cells secreting recombinant anti-amyloid-beta antibodies. When ...

Oxford Univ Press2016

Encapsulation device

Nicolas Bouche, Bernard Schneider, Aurélien Lathuilière

Provided herein is a cell encapsulation device comprising an internal chamber suitable for holding biological agents, wherein the internal chamber is disposed between a first semipermeable layer and a second semi-permeable layer, and the first and second s ...

2016

Suspension-Adapted HEK 293 Cells in Orbital Shaken Bioreactors for the Production of Adeno-Associated Virus Vectors

Florian Maria Wurm, Nicole Déglon, Bernard Schneider, Daniel Roman Blessing

Nature Publishing Group2016

Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis

Patrick Aebischer, Bernard Schneider, Cylia Cloé Rochat, Julianne Bobela, Nathalie Marie Géraldine Bernard

Nature Publishing Group2016

Characterization Of Motor And Sensory Neuronal Dysfunction In Both In Vitro And In Vivo Models Of Cmt2A Pathology

Bernard Schneider, Cylia Cloé Rochat, Roman Chrast, Nathalie Marie Géraldine Bernard

Wiley-Blackwell2016

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...

Mdpi Ag2015

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

Liliane Glauser, Bernard Schneider, Darren Moore, Alessandra Musso, Elpida Tsika, Aris Nikolaos Fiser, Guillaume Daniel

Mutations in the ATP13A2 (PARK9) gene cause early-onset, autosomal recessive Parkinson's disease (PD) and Kufor-Rakeb syndrome. ATP13A2 mRNA is spliced into three distinct isoforms encoding a P5-type ATPase involved in regulating heavy metal transport acro ...

Academic Press Inc Elsevier Science2015

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Pedro Andres Molina Cabrera

Matteo Fontana

Umar Sheikh

Cristian Galperti

Kevin Henricus Annemarie Verhaegh

Fusion power may be seen as the energy of the future in the sense that it composes a potentially clean, cheap and unlimited power source that would reduce the worldwide dependency on non-renewable energies. Nevertheless, while nowadays the fusion reaction ...

IEEE2018